ID A0A0S8EG36_9CHLR Unreviewed; 351 AA.
AC A0A0S8EG36;
DT 17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE SubName: Full=3-isopropylmalate dehydrogenase {ECO:0000313|EMBL:KPK47026.1};
DE EC=1.1.1.85 {ECO:0000313|EMBL:KPK47026.1};
GN ORFNames=AMJ77_04340 {ECO:0000313|EMBL:KPK47026.1};
OS Dehalococcoidia bacterium SM23_28_2.
OC Bacteria; Chloroflexota; Dehalococcoidia.
OX NCBI_TaxID=1703396 {ECO:0000313|EMBL:KPK47026.1, ECO:0000313|Proteomes:UP000054036};
RN [1] {ECO:0000313|EMBL:KPK47026.1, ECO:0000313|Proteomes:UP000054036}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SM23_28_2 {ECO:0000313|EMBL:KPK47026.1};
RX PubMed=25922666; DOI=10.1186/s40168-015-0077-6;
RA Baker B.J., Lazar C.S., Teske A.P., Dick G.J.;
RT "Genomic resolution of linkages in carbon, nitrogen, and sulfur cycling
RT among widespread estuary sediment bacteria.";
RL Microbiome 3:14-14(2015).
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPK47026.1}.
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DR EMBL; LJUA01000043; KPK47026.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0S8EG36; -.
DR STRING; 1703396.AMJ77_04340; -.
DR PATRIC; fig|1703396.3.peg.210; -.
DR Proteomes; UP000054036; Unassembled WGS sequence.
DR GO; GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR Gene3D; 3.40.718.10; Isopropylmalate Dehydrogenase; 1.
DR InterPro; IPR019818; IsoCit/isopropylmalate_DH_CS.
DR InterPro; IPR024084; IsoPropMal-DH-like_dom.
DR PANTHER; PTHR43275; D-MALATE DEHYDROGENASE [DECARBOXYLATING]; 1.
DR PANTHER; PTHR43275:SF1; D-MALATE DEHYDROGENASE [DECARBOXYLATING]; 1.
DR Pfam; PF00180; Iso_dh; 1.
DR SMART; SM01329; Iso_dh; 1.
DR SUPFAM; SSF53659; Isocitrate/Isopropylmalate dehydrogenase-like; 1.
DR PROSITE; PS00470; IDH_IMDH; 1.
PE 4: Predicted;
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Oxidoreductase {ECO:0000313|EMBL:KPK47026.1}.
FT DOMAIN 3..347
FT /note="Isopropylmalate dehydrogenase-like"
FT /evidence="ECO:0000259|SMART:SM01329"
SQ SEQUENCE 351 AA; 38264 MW; 3585795E41FBE196 CRC64;
MYKIAVIPGD GTGGEVVREG LKVLEAAAQA CGFRYDTTTY DFGGDRYLRT GETLPDSALE
ELRGFDAIYL GAIGHPDVPP GPLEVGILLR ARFGLDQYIN LRPVKLYPNV DCPLKDKGPE
DIDFVVVREN TEGLYSGMGG VQYKGTPQEV STQIHCTTRF GAERAIRYAF ELTRKRNKMK
QLHLVAKTNV LTYVHDTWWR AFCEVGDADY PEIRREYAHV DACCMWFVKN PEWFDVIVVD
NMFGDIITDL GAMIQGGMGV AAGGNINPQG VSMFEPIGGS APKYTGQNVI CPMAAIAAAQ
MMLDVIGEEE AADRVEKAMI KALGSGKIKS LAAGRMGMST SEVGDLVASL V
//
