ID   A0A0S8GKH9_9BACT        Unreviewed;       990 AA.
AC   A0A0S8GKH9;
DT   17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT   17-FEB-2016, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=Heterodisulfide reductase {ECO:0000313|EMBL:KPK73528.1};
GN   ORFNames=AMJ79_15075 {ECO:0000313|EMBL:KPK73528.1};
OS   Phycisphaerae bacterium SM23_30.
OC   Bacteria; Planctomycetota; Phycisphaerae.
OX   NCBI_TaxID=1703411 {ECO:0000313|EMBL:KPK73528.1, ECO:0000313|Proteomes:UP000051901};
RN   [1] {ECO:0000313|EMBL:KPK73528.1, ECO:0000313|Proteomes:UP000051901}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SM23_30 {ECO:0000313|EMBL:KPK73528.1};
RX   PubMed=25922666; DOI=10.1186/s40168-015-0077-6;
RA   Baker B.J., Lazar C.S., Teske A.P., Dick G.J.;
RT   "Genomic resolution of linkages in carbon, nitrogen, and sulfur cycling
RT   among widespread estuary sediment bacteria.";
RL   Microbiome 3:14-14(2015).
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|ARBA:ARBA00001974};
CC   -!- SIMILARITY: Belongs to the HdrA family.
CC       {ECO:0000256|ARBA:ARBA00006561}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KPK73528.1}.
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DR   EMBL; LJUC01000255; KPK73528.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0S8GKH9; -.
DR   STRING; 1703411.AMJ79_15075; -.
DR   PATRIC; fig|1703411.3.peg.2665; -.
DR   Proteomes; UP000051901; Unassembled WGS sequence.
DR   GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.70.20; -; 4.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR   InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR   InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR039650; HdrA-like.
DR   PANTHER; PTHR43498:SF1; COB--COM HETERODISULFIDE REDUCTASE IRON-SULFUR SUBUNIT A; 1.
DR   PANTHER; PTHR43498; FERREDOXIN:COB-COM HETERODISULFIDE REDUCTASE SUBUNIT A; 1.
DR   Pfam; PF13237; Fer4_10; 1.
DR   Pfam; PF12838; Fer4_7; 1.
DR   Pfam; PF13450; NAD_binding_8; 1.
DR   SUPFAM; SSF54862; 4Fe-4S ferredoxins; 2.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 2.
DR   PROSITE; PS00198; 4FE4S_FER_1; 3.
DR   PROSITE; PS51379; 4FE4S_FER_2; 4.
PE   3: Inferred from homology;
KW   FAD {ECO:0000256|ARBA:ARBA00022827};
KW   Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723}.
FT   DOMAIN          82..111
FT                   /note="4Fe-4S ferredoxin-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51379"
FT   DOMAIN          129..158
FT                   /note="4Fe-4S ferredoxin-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51379"
FT   DOMAIN          908..937
FT                   /note="4Fe-4S ferredoxin-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51379"
FT   DOMAIN          938..967
FT                   /note="4Fe-4S ferredoxin-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51379"
SQ   SEQUENCE   990 AA;  110517 MW;  2A4498F60DD7A0C3 CRC64;
     MQAALDCANS GLKAYLLEEH PSIGGNMAQL DKTFPTNDCS ICMLSPKLVE VGRHFNIEII
     AYADLEKVEG EPGNFKVTIN KRTRLVDEEK CNGCGDCEEA CPFKTLDVFN GELVERKAIY
     RLYPQAIPNV YTIDQETCTK CKKCVKVCKA EAIDHEMTDK KVPLEVGAII YAGGYDFFDA
     AQKPEYGFGR YPNVITSMQF ERILSASGPY AGHLERPSDR KAVKKIAWIQ CFGSRDVTCG
     NDYCSSVCCM YATKEAIIAK EHAGDVEPAI FFIDMRAFGK GFEGFYNRAQ NDYGVRYIRS
     QVSALKENPK NRNIFVRYIV GDNDSRIRIE EFDMVVLSVG LVAHRSTRKI AEICDLKCNR
     FGFIESRPQQ PVLSRREGIF LSGTVSGPRD IPETVMQSSA AAALCGQLLA SVRGAEVTVK
     QYPPELEVAE QKPRIGVFIC HCGSNIASVV DVEEVAQYIK KLEGVAHVEC NIYSCSQDSQ
     VHIKEVIQQK NLNRVVVASC TPRTHEPLFQ ETMRQAGLNK YLFEMTDIRE QCSWVHQQEP
     EKATDKAKDL IRGSVGKSRL LVPLEFKKVG VTKEALIVGG GISGMTAALS LANQDFQAHL
     VEKEPQLGGE LRHVKINLEG HNWQEYLENT IDQVQKHDKI KVYLDSEIDE VNGFVGNFTT
     RLKGPNPVEI KHGVIIVATG AKEFKPDRFL YGQNEKVITQ RQLEEKLQGD FSPETVVMIQ
     CVGSRDDERP YCSRICCGEA VKNALAIKEK NPDTKVYILY RDIRTYEYKE LYYLQAREKG
     VMFIHFPDDN YPQVSENAPG LKVSVRDTVI DETLDLQTDL VVLSAATVPE KENNQRLAEL
     LKVPLSEDKF FMEAHVKLRP VDFANEGIYL CGLAHSPKYT EENITQALAA AGRAACTLNK
     DSLEVGGVIS VIDEERCASC LTCLRECPYD APFINARGKA EIEAAKCQGC GNCVAACPAK
     AIQLRTFTDD QLRALFRSIL KVEEAAEVCS
//