ID A0A0T5P8Y0_9RHOB Unreviewed; 290 AA.
AC A0A0T5P8Y0;
DT 17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=2-hydroxy-3-oxopropionate reductase {ECO:0000313|EMBL:QEW26515.1};
DE EC=1.1.1.60 {ECO:0000313|EMBL:QEW26515.1};
DE SubName: Full=Oxidoreductase {ECO:0000313|EMBL:KRS17343.1};
GN Name=glxR {ECO:0000313|EMBL:QEW26515.1};
GN ORFNames=RIdsm_02315 {ECO:0000313|EMBL:QEW26515.1}, XM52_12630
GN {ECO:0000313|EMBL:KRS17343.1};
OS Roseovarius indicus.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Roseobacteraceae; Roseovarius.
OX NCBI_TaxID=540747 {ECO:0000313|EMBL:KRS17343.1, ECO:0000313|Proteomes:UP000051401};
RN [1] {ECO:0000313|EMBL:KRS17343.1, ECO:0000313|Proteomes:UP000051401}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B108 {ECO:0000313|EMBL:KRS17343.1,
RC ECO:0000313|Proteomes:UP000051401};
RA Li G., Lai Q., Shao Z., Yan P.;
RT "The draft genome sequence of Roseovarius indicus B108T.";
RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:QEW26515.1, ECO:0000313|Proteomes:UP000325785}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 26383 {ECO:0000313|EMBL:QEW26515.1,
RC ECO:0000313|Proteomes:UP000325785};
RA Vollmers J., Petersen J.;
RT "Genetic Globetrotter - A new plasmid hitch-hiking vast phylogenetic and
RT geographic distances.";
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the HIBADH-related family.
CC {ECO:0000256|ARBA:ARBA00009080}.
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DR EMBL; LAXI01000007; KRS17343.1; -; Genomic_DNA.
DR EMBL; CP031598; QEW26515.1; -; Genomic_DNA.
DR RefSeq; WP_057816505.1; NZ_CP031598.1.
DR AlphaFoldDB; A0A0T5P8Y0; -.
DR STRING; 540747.SAMN04488031_1011028; -.
DR KEGG; rid:RIdsm_02315; -.
DR PATRIC; fig|540747.5.peg.5559; -.
DR Proteomes; UP000051401; Unassembled WGS sequence.
DR Proteomes; UP000325785; Chromosome.
DR GO; GO:0008679; F:2-hydroxy-3-oxopropionate reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002204; 3-OH-isobutyrate_DH-rel_CS.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43060; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR PANTHER; PTHR43060:SF15; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00895; 3_HYDROXYISOBUT_DH; 1.
PE 3: Inferred from homology;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000313|EMBL:QEW26515.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000051401}.
FT DOMAIN 3..160
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 166..284
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT ACT_SITE 172
FT /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ SEQUENCE 290 AA; 30646 MW; 9B49A5F2AE6E2C4E CRC64;
MTKLAFLGLG VMGYPMAGHL QAAGHEVCVY NRTTAKAEKW VDQHGGTHAP TPREAADGAD
FVMSCVGNDD DLRSVCLGDD GAFAGMKTGA TFVDHTTVSA KVTEELYAAA KEAGLGYVDA
PISGGQAGAE NGQLSIMCGG DEDIYAAAEP VMNTYAKLCR RIGGSGAGQM TKMANQIAIA
GLVQGLSEAL HFAEKAGLDG RSVVEVISQG AAGSWQMANR YETMLDDKFD HGFAVDWMRK
DLGICLDTAN ENGASLPVTA LVDQYYKDVQ KMGGGRWDTS SLFKRLRKLG
//
