ID A0A0T5P9Y4_9RHOB Unreviewed; 1152 AA.
AC A0A0T5P9Y4;
DT 17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE RecName: Full=Transcription-repair-coupling factor {ECO:0000256|HAMAP-Rule:MF_00969};
DE Short=TRCF {ECO:0000256|HAMAP-Rule:MF_00969};
DE EC=3.6.4.- {ECO:0000256|HAMAP-Rule:MF_00969};
GN Name=mfd {ECO:0000256|HAMAP-Rule:MF_00969,
GN ECO:0000313|EMBL:QEW27195.1};
GN ORFNames=RIdsm_03006 {ECO:0000313|EMBL:QEW27195.1}, XM52_10545
GN {ECO:0000313|EMBL:KRS17984.1};
OS Roseovarius indicus.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Roseobacteraceae; Roseovarius.
OX NCBI_TaxID=540747 {ECO:0000313|EMBL:KRS17984.1, ECO:0000313|Proteomes:UP000051401};
RN [1] {ECO:0000313|EMBL:KRS17984.1, ECO:0000313|Proteomes:UP000051401}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B108 {ECO:0000313|EMBL:KRS17984.1,
RC ECO:0000313|Proteomes:UP000051401};
RA Li G., Lai Q., Shao Z., Yan P.;
RT "The draft genome sequence of Roseovarius indicus B108T.";
RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:QEW27195.1, ECO:0000313|Proteomes:UP000325785}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 26383 {ECO:0000313|EMBL:QEW27195.1,
RC ECO:0000313|Proteomes:UP000325785};
RA Vollmers J., Petersen J.;
RT "Genetic Globetrotter - A new plasmid hitch-hiking vast phylogenetic and
RT geographic distances.";
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Couples transcription and DNA repair by recognizing RNA
CC polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent
CC release of RNAP and its truncated transcript from the DNA, and
CC recruitment of nucleotide excision repair machinery to the damaged
CC site. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the helicase family.
CC RecG subfamily. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the UvrB family.
CC {ECO:0000256|HAMAP-Rule:MF_00969}.
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DR EMBL; LAXI01000005; KRS17984.1; -; Genomic_DNA.
DR EMBL; CP031598; QEW27195.1; -; Genomic_DNA.
DR RefSeq; WP_057816031.1; NZ_LAXI01000005.1.
DR AlphaFoldDB; A0A0T5P9Y4; -.
DR STRING; 540747.SAMN04488031_101339; -.
DR KEGG; rid:RIdsm_03006; -.
DR PATRIC; fig|540747.5.peg.5034; -.
DR OrthoDB; 9804325at2; -.
DR Proteomes; UP000051401; Unassembled WGS sequence.
DR Proteomes; UP000325785; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR GO; GO:0000716; P:transcription-coupled nucleotide-excision repair, DNA damage recognition; IEA:UniProtKB-UniRule.
DR CDD; cd17991; DEXHc_TRCF; 1.
DR Gene3D; 2.40.10.170; -; 1.
DR Gene3D; 3.40.50.11180; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.2060.10; Penicillin-binding protein 1b domain; 1.
DR Gene3D; 3.90.1150.50; Transcription-repair-coupling factor, D7 domain; 1.
DR HAMAP; MF_00969; TRCF; 1.
DR InterPro; IPR003711; CarD-like/TRCF_RID.
DR InterPro; IPR036101; CarD-like/TRCF_RID_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR004576; Mfd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047112; RecG/Mfd.
DR InterPro; IPR037235; TRCF-like_C_D7.
DR InterPro; IPR005118; TRCF_C.
DR InterPro; IPR041471; UvrB_inter.
DR NCBIfam; TIGR00580; mfd; 1.
DR PANTHER; PTHR47964; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR PANTHER; PTHR47964:SF1; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR Pfam; PF02559; CarD_TRCF_RID; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF03461; TRCF; 1.
DR Pfam; PF17757; UvrB_inter; 1.
DR SMART; SM01058; CarD_TRCF; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00982; TRCF; 1.
DR SUPFAM; SSF141259; CarD-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR SUPFAM; SSF143517; TRCF domain-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00969};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Reference proteome {ECO:0000313|Proteomes:UP000051401}.
FT DOMAIN 611..772
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 793..947
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 1152 AA; 127084 MW; A634ABC507CD4919 CRC64;
MSEAKHIVVG GAPEGFDARL VLKEAERDGG PVIHVARDDK RLAQMAEALA FFAPGMPVLR
FPGWDCLPYD RISPNADISA ARMATLAGLV HGAPKQFVLL TTLNAATQRV PPRDVLKEAA
FTAEVDQRID EDALKAFLVR MGFVQSPTVT EPGDYAVRGG IIDIFPPGEG GPVRLDLFGD
VLDGVRGFDP GSQRTTEKLS RVELAPVSEV ILDEASITRF RQNYRIEFGA AGTDDPLYEA
VSAGRKHAGI EHWLPFFHEK LETLFDYLPG APVTLDDQVE AARLSRWDTV QDQYEARRHA
LEQKQRAETI YKPVPPGQLY LDDDAWNAAV ADRRRLAFSP LAKSPGPNII DAGGRIGRNF
SPERQQESIS LFGALKDHIE AKMADGPVLL ASYSEGARER LEGLLEDEGL IGAVTVRDVG
GVGKRGLHLA VWGLEHGFES PGLTVIAEQD VLGDRLIRSP RKRRRAENFL TEAQSLSPGD
LVVHVDHGIG RYHGLEVITA AGAAHECLSL EYAEGARLYL PVENIELLSR YGHEEGLLDR
LGGGAWQAKK AKLKERIREM ADRLIRIAAE RALRKGAVME PEHHAWEAFS ARFPYQETDD
QLRAIEDVVN DLSSGTPMDR LICGDVGFGK TEVAMRAAFV AALQGYQVAV IAPTTLLARQ
HYQSFAERFR GFPISVRPLS RFVSTTEAAK TREALSRGQV DIVVGTHALL AKSVRFANLG
LLVIDEEQRF GVAHKERLKQ LRSDVHVLTL TATPIPRTLQ LSLSGVRDLS IIGTPPVDRL
SIRTYVSEFD TVTIREALLR EHYRGGQSFF VVPRIKDLAE IEQFLEEQVP EVSYVVAHGQ
MAAGELDNRM NAFYDGKFDV LLATTIVESG LDIPTANTMV VHRADMFGLS QLYQIRGRVG
RSKVRAYAYL TTKPRVPLTP AAEKRLRVLG SLDTLGAGFT LASQDLDIRG AGNLLGEEQS
GQMRDVGYEL YQSMLEEAIA KIKAGELEGL TETDEQWAPQ INLGVPVLIP EDYVPDLDVR
LGLYRRLSGL HTKVELEGFA AELIDRFGKL PKEVNTLLLI VRIKAMCKRA GIAKLDGGPK
GATIQFHNDK FASPEGLVQF MQDQRGMAKV KDNKIVVRRD WKKESDKIKG AFAIARDLAE
KVVEKKKSGA KS
//
