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Database: UniProt
Entry: A0A0T5ZSJ6_9BACT
LinkDB: A0A0T5ZSJ6_9BACT
Original site: A0A0T5ZSJ6_9BACT 
ID   A0A0T5ZSJ6_9BACT        Unreviewed;       456 AA.
AC   A0A0T5ZSJ6;
DT   17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT   17-FEB-2016, sequence version 1.
DT   25-APR-2018, entry version 14.
DE   RecName: Full=Exodeoxyribonuclease 7 large subunit {ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723543};
DE            EC=3.1.11.6 {ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723538};
DE   Flags: Fragment;
GN   ORFNames=XU13_C0126G0001 {ECO:0000313|EMBL:KRT65773.1};
OS   Candidatus Rokubacteria bacterium CSP1-6.
OC   Bacteria; Candidatus Rokubacteria.
OX   NCBI_TaxID=1640509 {ECO:0000313|EMBL:KRT65773.1};
RN   [1] {ECO:0000313|EMBL:KRT65773.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CSP1-6 {ECO:0000313|EMBL:KRT65773.1};
RA   Hug L.A., Thomas B.C., Sharon I., Brown C.T., Sharma R., Hettich R.L.,
RA   Wilkins M.J., Williams K.H., Singh A., Banfield J.F.;
RT   "Critical biogeochemical functions in the subsurface are associated
RT   with bacteria from new phyla and little studied lineages.";
RL   Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Bidirectionally degrades single-stranded DNA into large
CC       acid-insoluble oligonucleotides, which are then degraded further
CC       into small acid-soluble oligonucleotides.
CC       {ECO:0000256|SAAS:SAAS00723532}.
CC   -!- CATALYTIC ACTIVITY: Exonucleolytic cleavage in either 5'- to
CC       3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.
CC       {ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723505}.
CC   -!- SUBUNIT: Heterooligomer composed of large and small subunits.
CC       {ECO:0000256|SAAS:SAAS00984457}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU004355,
CC       ECO:0000256|SAAS:SAAS00723552}.
CC   -!- SIMILARITY: Belongs to the XseA family.
CC       {ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723548}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KRT65773.1}.
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DR   EMBL; LDXP01000126; KRT65773.1; -; Genomic_DNA.
DR   PATRIC; fig|1640509.3.peg.2980; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009318; C:exodeoxyribonuclease VII complex; IEA:InterPro.
DR   GO; GO:0008855; F:exodeoxyribonuclease VII activity; IEA:UniProtKB-EC.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006308; P:DNA catabolic process; IEA:InterPro.
DR   CDD; cd04489; ExoVII_LU_OBF; 1.
DR   HAMAP; MF_00378; Exonuc_7_L; 1.
DR   InterPro; IPR003753; Exonuc_VII_L.
DR   InterPro; IPR020579; Exonuc_VII_lsu_C.
DR   InterPro; IPR025824; OB-fold_nuc-bd_dom.
DR   PANTHER; PTHR30008; PTHR30008; 1.
DR   Pfam; PF02601; Exonuc_VII_L; 1.
DR   Pfam; PF13742; tRNA_anti_2; 1.
DR   TIGRFAMs; TIGR00237; xseA; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|SAAS:SAAS00723549};
KW   Exonuclease {ECO:0000256|RuleBase:RU004355,
KW   ECO:0000256|SAAS:SAAS00723511};
KW   Hydrolase {ECO:0000256|RuleBase:RU004355,
KW   ECO:0000256|SAAS:SAAS00723558, ECO:0000313|EMBL:KRT65773.1};
KW   Nuclease {ECO:0000256|RuleBase:RU004355,
KW   ECO:0000256|SAAS:SAAS00723518}.
FT   DOMAIN       12    104       tRNA_anti_2. {ECO:0000259|Pfam:PF13742}.
FT   DOMAIN      128    441       Exonuc_VII_L. {ECO:0000259|Pfam:PF02601}.
FT   COILED      314    334       {ECO:0000256|SAM:Coils}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:KRT65773.1}.
SQ   SEQUENCE   456 AA;  50349 MW;  666B53AEDC0C6422 CRC64;
     PRCRMSDDRH VWTVSVLTAR IKERLEAEFP AFWVEGEISN FRVSNAGHAY FTLKDETASL
     KAVLFKGKAR RVRFEPQDGL HVLAFGGLDL YAQRGEYQLV VELLEPKGLG ALQLAFEQLK
     AKLAAEGLFD PARKRPLPRF PRKLGIVTSP GGAAIRDILQ IISRRFADLH IVIAPVRVQG
     EEAAGEIVGA LQDLNRLGDL DVIIVARGGG SLEDLWAFNE EAVARAVAGS KVPVISAVGH
     ETDWTIADFV ADLRAPTPSG AAELVVEEKE AVAELVADLY DRLKRVVIQR IARHRERVES
     LARRRVLTDP ARPVRDLERR LDELTARLAA GLTAARREAR HRALLATNSL LSKSPLARIS
     STATLLEQLD GRLHSGIRHS AERMRHRLRT AVGQLDSLSP LAVLRRGYSL TRLPSGEIVR
     SGRQVGAGSE IQVLLHEGTL GARVTEVRER DDRPQV
//
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