ID A0A0T6B226_9SCAR Unreviewed; 557 AA.
AC A0A0T6B226;
DT 17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Ras-GEF domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=AMK59_6176 {ECO:0000313|EMBL:KRT81491.1};
OS Oryctes borbonicus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Scarabaeiformia;
OC Scarabaeidae; Dynastinae; Oryctes.
OX NCBI_TaxID=1629725 {ECO:0000313|EMBL:KRT81491.1, ECO:0000313|Proteomes:UP000051574};
RN [1] {ECO:0000313|EMBL:KRT81491.1, ECO:0000313|Proteomes:UP000051574}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OB123 {ECO:0000313|EMBL:KRT81491.1};
RC TISSUE=Whole animal {ECO:0000313|EMBL:KRT81491.1};
RA Meyer J.M., Markov G.V., Baskaran P., Herrmann M., Sommer R.J.,
RA Roedelsperger C.;
RT "Draft genome of the scarab beetle Oryctes borbonicus.";
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRT81491.1}.
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DR EMBL; LJIG01016141; KRT81491.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0T6B226; -.
DR OrthoDB; 68574at2759; -.
DR Proteomes; UP000051574; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF99; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000051574}.
FT DOMAIN 180..302
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 326..550
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 29..157
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 29..113
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 134..152
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 557 AA; 63785 MW; CA35235158F16434 CRC64;
MAYMEMFGNC SHSNDSEFMR HSVHIQGLWS QSPKPGLPTT QSCSFSHTSS QSSSRSSHTQ
VQNLTIPYSS GDSSPIPSPL RSPNSISTPI SSSVTPPALP PKRSKSSSSK SSPPATPQAP
PTVESKSPMK SLPDLLEHTT NNNKTVEESP ATSDVSCDMD FMEKSPDIEK FLVFKSAEDD
GPDIRGGCID ALIIQATKAT KNGVFAYQEA FLTTYRTFIT PYELITKLIR RFHYFYLQPD
KKPKEAFALI IRVVSDFTPS DLDSATQQML MDFVQRLISY GEITLAKALR VKHLERHNVK
LLSIRGPVIE FPCTKNRSTY NLLDFKSEQI AEQMTFLDAE LFMKIEIPEV LIWAQEQNEE
RSPNLTRFTE HFNKMSYWAR TKILLVDAKD RERYFLKFIK IMKHLRKINN FNSYLALLSA
LDSAPIRRLE WQKHVQEGLK EYCALIDSSS SFRAYRQALA ETNPPCIPYI GLVLQDLTFV
HIGNSNLLPN GLINFSKRWQ QYNIVENMKR FKKCAYSFKR NDKIIDFFQN FDDYITEDEM
WARSEFIKPR GTKKQAQ
//
