ID A0A0T7BWV3_9CYAN Unreviewed; 388 AA.
AC A0A0T7BWV3;
DT 17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=UTP--glucose-1-phosphate uridylyltransferase {ECO:0000256|HAMAP-Rule:MF_02085};
DE EC=2.7.7.9 {ECO:0000256|HAMAP-Rule:MF_02085};
DE AltName: Full=Cyanobacterial UDP-glucose pyrophosphorylase {ECO:0000256|HAMAP-Rule:MF_02085};
DE AltName: Full=UDP-glucose pyrophosphorylase {ECO:0000256|HAMAP-Rule:MF_02085};
DE Short=UDP-Glc PPase {ECO:0000256|HAMAP-Rule:MF_02085};
GN Name=cugP {ECO:0000256|HAMAP-Rule:MF_02085};
GN ORFNames=IJ00_22025 {ECO:0000313|EMBL:AKG23605.1};
OS Calothrix sp. 336/3.
OC Bacteria; Cyanobacteriota; Cyanophyceae; Nostocales; Calotrichaceae;
OC Calothrix.
OX NCBI_TaxID=1337936 {ECO:0000313|EMBL:AKG23605.1, ECO:0000313|Proteomes:UP000065745};
RN [1] {ECO:0000313|EMBL:AKG23605.1, ECO:0000313|Proteomes:UP000065745}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=336/3 {ECO:0000313|EMBL:AKG23605.1,
RC ECO:0000313|Proteomes:UP000065745};
RX PubMed=25614574;
RA Isojarvi J., Shunmugam S., Sivonen K., Allahverdiyeva Y., Aro E.M.,
RA Battchikova N.;
RT "Draft genome sequence of calothrix strain 336/3, a novel h2-producing
RT cyanobacterium isolated from a finnish lake.";
RL Genome Announc. 3:0-0(2015).
CC -!- FUNCTION: Catalyzes the formation of UDP-glucose, from UTP and glucose
CC 1-phosphate. {ECO:0000256|HAMAP-Rule:MF_02085}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP-
CC alpha-D-glucose; Xref=Rhea:RHEA:19889, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:46398, ChEBI:CHEBI:58601,
CC ChEBI:CHEBI:58885; EC=2.7.7.9; Evidence={ECO:0000256|HAMAP-
CC Rule:MF_02085};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|HAMAP-Rule:MF_02085};
CC -!- SIMILARITY: Belongs to the CugP-type UDP-glucose pyrophosphorylase
CC family. {ECO:0000256|HAMAP-Rule:MF_02085}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP011382; AKG23605.1; -; Genomic_DNA.
DR RefSeq; WP_035156783.1; NZ_CP011382.1.
DR AlphaFoldDB; A0A0T7BWV3; -.
DR STRING; 1337936.IJ00_22025; -.
DR KEGG; calh:IJ00_22025; -.
DR eggNOG; COG1208; Bacteria.
DR OrthoDB; 9803871at2; -.
DR Proteomes; UP000065745; Chromosome.
DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0002134; F:UTP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003983; F:UTP:glucose-1-phosphate uridylyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR GO; GO:0006011; P:UDP-glucose metabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd04181; NTP_transferase; 1.
DR Gene3D; 2.160.10.10; Hexapeptide repeat proteins; 1.
DR HAMAP; MF_02085; CugP_cyano; 1.
DR InterPro; IPR037538; CugP_cyano.
DR InterPro; IPR005835; NTP_transferase_dom.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR22572; SUGAR-1-PHOSPHATE GUANYL TRANSFERASE; 1.
DR PANTHER; PTHR22572:SF137; UTP--GLUCOSE-1-PHOSPHATE URIDYLYLTRANSFERASE; 1.
DR Pfam; PF00483; NTP_transferase; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 3: Inferred from homology;
KW Magnesium {ECO:0000256|HAMAP-Rule:MF_02085};
KW Metal-binding {ECO:0000256|HAMAP-Rule:MF_02085};
KW Nucleotidyltransferase {ECO:0000256|HAMAP-Rule:MF_02085};
KW Reference proteome {ECO:0000313|Proteomes:UP000065745};
KW Transferase {ECO:0000256|HAMAP-Rule:MF_02085, ECO:0000313|EMBL:AKG23605.1}.
FT DOMAIN 2..245
FT /note="Nucleotidyl transferase"
FT /evidence="ECO:0000259|Pfam:PF00483"
FT BINDING 118
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_02085"
SQ SEQUENCE 388 AA; 42465 MW; 0EAA6C4B402716C9 CRC64;
MKAMILAAGK GTRVRPITYT IPKPMIPILQ KPVMEFLLEL LRQHGFDQIM VNVSHLAEEI
ESYFRDGQRF GVEIAYSFEG RIVDGTLVGE ALGSAGGMRR IQDFSPFFDD TFVVLCGDAL
IDLDLTEAVK WHRSKGAIAT IITKTVPQEE VSSYGVVVTD DDGKIQAFQE KPSIEEAKST
NINTGIYIFE PEIFNYIPSG VEFDIGGDLF PKLVEVGAPF YAIPMDFEWV DIGKVPDYWR
AIRGVLSGEI KNVQIPGNQV APGIYTGLNV AVNWDKVDIT GPVYIGGMTR IEDGAKIVGP
AMIGPNCWVC SGATVDNSVI FEWSRLGAGV SLVDKLVFGR YCVDKAGATI DLQAAALDWL
ITDARQDLPT QTSMERQAIA ELLGTNAN
//
