ID A0A0T7RTA6_SALET Unreviewed; 251 AA.
AC A0A0T7RTA6;
DT 17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=Malonyl-[acyl-carrier protein] O-methyltransferase {ECO:0000256|ARBA:ARBA00012327, ECO:0000256|HAMAP-Rule:MF_00835};
DE Short=Malonyl-ACP O-methyltransferase {ECO:0000256|HAMAP-Rule:MF_00835};
DE EC=2.1.1.197 {ECO:0000256|ARBA:ARBA00012327, ECO:0000256|HAMAP-Rule:MF_00835};
DE AltName: Full=Biotin synthesis protein BioC {ECO:0000256|HAMAP-Rule:MF_00835};
GN Name=bioC {ECO:0000256|HAMAP-Rule:MF_00835,
GN ECO:0000313|EMBL:SUE48196.1};
GN ORFNames=B7N00_09895 {ECO:0000313|EMBL:EDG5017265.1}, B7N01_13110
GN {ECO:0000313|EMBL:EDG4995365.1}, B7N35_14305
GN {ECO:0000313|EMBL:EDG5127194.1}, B7N72_12985
GN {ECO:0000313|EMBL:EDG5371019.1}, B7N78_15980
GN {ECO:0000313|EMBL:EDG5281259.1}, B7N80_17490
GN {ECO:0000313|EMBL:EDG5290171.1}, B7N84_16545
GN {ECO:0000313|EMBL:EDG5267943.1}, DRU31_14365
GN {ECO:0000313|EMBL:EBS2453478.1}, E0916_16175
GN {ECO:0000313|EMBL:ECF1447484.1}, EJV93_17010
GN {ECO:0000313|EMBL:ECA2722886.1}, EWC73_13005
GN {ECO:0000313|EMBL:ECE8537109.1}, G0B02_17260
GN {ECO:0000313|EMBL:HAC6380825.1}, G0D18_14505
GN {ECO:0000313|EMBL:HAC6681842.1}, G2206_05910
GN {ECO:0000313|EMBL:HAE0434311.1}, NCTC5754_03132
GN {ECO:0000313|EMBL:SUE48196.1};
OS Salmonella enterica subsp. enterica serovar Bovismorbificans.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=58097 {ECO:0000313|EMBL:SUE48196.1, ECO:0000313|Proteomes:UP000254190};
RN [1] {ECO:0000313|EMBL:HAC6380825.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=BCW_3301 {ECO:0000313|EMBL:HAC6380825.1}, M123
RC {ECO:0000313|EMBL:HAC6681842.1}, and MS140073
RC {ECO:0000313|EMBL:HAE0434311.1};
RX PubMed=30286803;
RA Souvorov A., Agarwala R., Lipman D.J.;
RT "SKESA: strategic k-mer extension for scrupulous assemblies.";
RL Genome Biol. 19:153-153(2018).
RN [2] {ECO:0000313|EMBL:SUE48196.1, ECO:0000313|Proteomes:UP000254190}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC5754 {ECO:0000313|EMBL:SUE48196.1,
RC ECO:0000313|Proteomes:UP000254190};
RG Pathogen Informatics;
RA Doyle S.;
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:EBS2453478.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=136768 {ECO:0000313|EMBL:EDG4995365.1}, 138330
RC {ECO:0000313|EMBL:EDG5290171.1}, 143652
RC {ECO:0000313|EMBL:EDG5371019.1}, 273631
RC {ECO:0000313|EMBL:EDG5017265.1}, 330535
RC {ECO:0000313|EMBL:EDG5267943.1}, 333944
RC {ECO:0000313|EMBL:EDG5281259.1}, 337042
RC {ECO:0000313|EMBL:EDG5127194.1}, 387147
RC {ECO:0000313|EMBL:EBS2453478.1}, 470200
RC {ECO:0000313|EMBL:ECE8537109.1}, 598023
RC {ECO:0000313|EMBL:ECA2722886.1}, and 692616
RC {ECO:0000313|EMBL:ECF1447484.1};
RA Ashton P.M., Dallman T., Nair S., De Pinna E., Peters T., Grant K.;
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:HAC6380825.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=BCW_3301 {ECO:0000313|EMBL:HAC6380825.1}, M123
RC {ECO:0000313|EMBL:HAC6681842.1}, and MS140073
RC {ECO:0000313|EMBL:HAE0434311.1};
RG NCBI Pathogen Detection Project;
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Converts the free carboxyl group of a malonyl-thioester to
CC its methyl ester by transfer of a methyl group from S-adenosyl-L-
CC methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty
CC acid synthetic pathway. {ECO:0000256|HAMAP-Rule:MF_00835}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=malonyl-[ACP] + S-adenosyl-L-methionine = malonyl-[ACP] methyl
CC ester + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:17105, Rhea:RHEA-
CC COMP:9623, Rhea:RHEA-COMP:9954, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:78449, ChEBI:CHEBI:78845; EC=2.1.1.197;
CC Evidence={ECO:0000256|ARBA:ARBA00000852, ECO:0000256|HAMAP-
CC Rule:MF_00835};
CC -!- PATHWAY: Cofactor biosynthesis; biotin biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004746, ECO:0000256|HAMAP-Rule:MF_00835}.
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily.
CC {ECO:0000256|HAMAP-Rule:MF_00835}.
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DR EMBL; AAGUWJ010000010; EBS2453478.1; -; Genomic_DNA.
DR EMBL; AAHTVM010000009; ECA2722886.1; -; Genomic_DNA.
DR EMBL; AAIJHK010000010; ECE8537109.1; -; Genomic_DNA.
DR EMBL; AAIKGE010000010; ECF1447484.1; -; Genomic_DNA.
DR EMBL; AAMEJW010000012; EDG4995365.1; -; Genomic_DNA.
DR EMBL; AAMEJY010000004; EDG5017265.1; -; Genomic_DNA.
DR EMBL; AAMEKY010000011; EDG5127194.1; -; Genomic_DNA.
DR EMBL; AAMEMC010000009; EDG5267943.1; -; Genomic_DNA.
DR EMBL; AAMEMH010000011; EDG5281259.1; -; Genomic_DNA.
DR EMBL; AAMEML010000022; EDG5290171.1; -; Genomic_DNA.
DR EMBL; AAMEMP010000012; EDG5371019.1; -; Genomic_DNA.
DR EMBL; DAAMEZ010000012; HAC6380825.1; -; Genomic_DNA.
DR EMBL; DAAMHM010000010; HAC6681842.1; -; Genomic_DNA.
DR EMBL; DAAQQK010000004; HAE0434311.1; -; Genomic_DNA.
DR EMBL; UGVQ01000002; SUE48196.1; -; Genomic_DNA.
DR RefSeq; WP_000079910.1; NZ_WFIN01000001.1.
DR AlphaFoldDB; A0A0T7RTA6; -.
DR UniPathway; UPA00078; -.
DR Proteomes; UP000254190; Unassembled WGS sequence.
DR Proteomes; UP000839929; Unassembled WGS sequence.
DR GO; GO:0010340; F:carboxyl-O-methyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0102130; F:malonyl-CoA methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:InterPro.
DR GO; GO:0009102; P:biotin biosynthetic process; IEA:UniProtKB-UniRule.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR HAMAP; MF_00835; BioC; 1.
DR InterPro; IPR011814; BioC.
DR InterPro; IPR013216; Methyltransf_11.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR NCBIfam; TIGR02072; BioC; 1.
DR PANTHER; PTHR43464:SF95; MALONYL-[ACYL-CARRIER PROTEIN] O-METHYLTRANSFERASE; 1.
DR PANTHER; PTHR43464; METHYLTRANSFERASE; 1.
DR Pfam; PF08241; Methyltransf_11; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 3: Inferred from homology;
KW Biotin biosynthesis {ECO:0000256|HAMAP-Rule:MF_00835};
KW Methyltransferase {ECO:0000256|HAMAP-Rule:MF_00835,
KW ECO:0000313|EMBL:SUE48196.1};
KW S-adenosyl-L-methionine {ECO:0000256|HAMAP-Rule:MF_00835};
KW Transferase {ECO:0000256|HAMAP-Rule:MF_00835, ECO:0000313|EMBL:SUE48196.1}.
FT DOMAIN 47..138
FT /note="Methyltransferase type 11"
FT /evidence="ECO:0000259|Pfam:PF08241"
SQ SEQUENCE 251 AA; 28223 MW; CD026EC21EE03BF3 CRC64;
MAQVNKQAIA AAFGRAASQY EQHASLQQHS ADALLTLLTG RQFASVLDAG CGPGRMSRYW
RERGSEVTAL DLSLPMLQQA RDRQAAHHYL LADIEAIPHD AEVFDLAWSN LAVQWCGDLR
DALSELYRVV RPGGVVAFTT LCQGSLPELR QAWQAVDNRA HANSFLPEEA IDHALRGWRA
FRHTQAMTLW FEDALSAMRS LKGIGATHLH EGRETDVLTR ARLRQIQLAW PQRQGKYPLT
YHLFMGVIER D
//
