ID A0A0T7RYT0_SALET Unreviewed; 603 AA.
AC A0A0T7RYT0;
DT 17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 1.
DT 24-JAN-2024, entry version 47.
DE RecName: Full=Phosphogluconate dehydratase {ECO:0000256|HAMAP-Rule:MF_02094};
DE EC=4.2.1.12 {ECO:0000256|HAMAP-Rule:MF_02094};
GN Name=edd {ECO:0000256|HAMAP-Rule:MF_02094,
GN ECO:0000313|EMBL:SUE47154.1};
GN ORFNames=B7N00_04375 {ECO:0000313|EMBL:EDG5016204.1}, B7N01_00730
GN {ECO:0000313|EMBL:EDG4992966.1}, B7N35_09630
GN {ECO:0000313|EMBL:EDG5126283.1}, B7N72_03785
GN {ECO:0000313|EMBL:EDG5369241.1}, B7N78_11860
GN {ECO:0000313|EMBL:EDG5280460.1}, B7N80_06960
GN {ECO:0000313|EMBL:EDG5288115.1}, B7N84_00750
GN {ECO:0000313|EMBL:EDG5264892.1}, DRU31_10015
GN {ECO:0000313|EMBL:EBS2452649.1}, E0916_00735
GN {ECO:0000313|EMBL:ECF1444513.1}, EJV93_03530
GN {ECO:0000313|EMBL:ECA2720305.1}, ERS008202_04465
GN {ECO:0000313|EMBL:CNV15384.1}, ERS008207_04733
GN {ECO:0000313|EMBL:CNV25251.1}, EWC73_09140
GN {ECO:0000313|EMBL:ECE8536367.1}, G0B02_14630
GN {ECO:0000313|EMBL:HAC6380327.1}, G0D18_12715
GN {ECO:0000313|EMBL:HAC6681499.1}, G2206_02115
GN {ECO:0000313|EMBL:HAE0433591.1}, NCTC5754_02033
GN {ECO:0000313|EMBL:SUE47154.1};
OS Salmonella enterica subsp. enterica serovar Bovismorbificans.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=58097 {ECO:0000313|EMBL:SUE47154.1, ECO:0000313|Proteomes:UP000254190};
RN [1] {ECO:0000313|Proteomes:UP000039541, ECO:0000313|Proteomes:UP000042394}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3476 {ECO:0000313|EMBL:CNV15384.1,
RC ECO:0000313|Proteomes:UP000039541}, and D4891
RC {ECO:0000313|EMBL:CNV25251.1, ECO:0000313|Proteomes:UP000042394};
RG Pathogen Informatics;
RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:HAC6380327.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=BCW_3301 {ECO:0000313|EMBL:HAC6380327.1}, M123
RC {ECO:0000313|EMBL:HAC6681499.1}, and MS140073
RC {ECO:0000313|EMBL:HAE0433591.1};
RX PubMed=30286803;
RA Souvorov A., Agarwala R., Lipman D.J.;
RT "SKESA: strategic k-mer extension for scrupulous assemblies.";
RL Genome Biol. 19:153-153(2018).
RN [3] {ECO:0000313|EMBL:SUE47154.1, ECO:0000313|Proteomes:UP000254190}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC5754 {ECO:0000313|EMBL:SUE47154.1,
RC ECO:0000313|Proteomes:UP000254190};
RG Pathogen Informatics;
RA Doyle S.;
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:HAC6681499.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=BCW_3301 {ECO:0000313|EMBL:HAC6380327.1}, M123
RC {ECO:0000313|EMBL:HAC6681499.1}, and MS140073
RC {ECO:0000313|EMBL:HAE0433591.1};
RG NCBI Pathogen Detection Project;
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|EMBL:EBS2452649.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=136768 {ECO:0000313|EMBL:EDG4992966.1}, 138330
RC {ECO:0000313|EMBL:EDG5288115.1}, 143652
RC {ECO:0000313|EMBL:EDG5369241.1}, 273631
RC {ECO:0000313|EMBL:EDG5016204.1}, 330535
RC {ECO:0000313|EMBL:EDG5264892.1}, 333944
RC {ECO:0000313|EMBL:EDG5280460.1}, 337042
RC {ECO:0000313|EMBL:EDG5126283.1}, 387147
RC {ECO:0000313|EMBL:EBS2452649.1}, 470200
RC {ECO:0000313|EMBL:ECE8536367.1}, 598023
RC {ECO:0000313|EMBL:ECA2720305.1}, and 692616
RC {ECO:0000313|EMBL:ECF1444513.1};
RA Ashton P.M., Dallman T., Nair S., De Pinna E., Peters T., Grant K.;
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the dehydration of 6-phospho-D-gluconate to 2-
CC dehydro-3-deoxy-6-phospho-D-gluconate. {ECO:0000256|HAMAP-
CC Rule:MF_02094}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=6-phospho-D-gluconate = 2-dehydro-3-deoxy-6-phospho-D-
CC gluconate + H2O; Xref=Rhea:RHEA:17277, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:57569, ChEBI:CHEBI:58759; EC=4.2.1.12;
CC Evidence={ECO:0000256|HAMAP-Rule:MF_02094};
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|HAMAP-Rule:MF_02094};
CC Note=Binds 1 [4Fe-4S] cluster. {ECO:0000256|HAMAP-Rule:MF_02094};
CC -!- PATHWAY: Carbohydrate metabolism; Entner-Doudoroff pathway.
CC {ECO:0000256|HAMAP-Rule:MF_02094}.
CC -!- SIMILARITY: Belongs to the IlvD/Edd family.
CC {ECO:0000256|ARBA:ARBA00006486, ECO:0000256|HAMAP-Rule:MF_02094}.
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DR EMBL; CQPC01000093; CNV15384.1; -; Genomic_DNA.
DR EMBL; CQPD01000081; CNV25251.1; -; Genomic_DNA.
DR EMBL; AAGUWJ010000006; EBS2452649.1; -; Genomic_DNA.
DR EMBL; AAHTVM010000002; ECA2720305.1; -; Genomic_DNA.
DR EMBL; AAIJHK010000006; ECE8536367.1; -; Genomic_DNA.
DR EMBL; AAIKGE010000001; ECF1444513.1; -; Genomic_DNA.
DR EMBL; AAMEJW010000001; EDG4992966.1; -; Genomic_DNA.
DR EMBL; AAMEJY010000002; EDG5016204.1; -; Genomic_DNA.
DR EMBL; AAMEKY010000006; EDG5126283.1; -; Genomic_DNA.
DR EMBL; AAMEMC010000001; EDG5264892.1; -; Genomic_DNA.
DR EMBL; AAMEMH010000007; EDG5280460.1; -; Genomic_DNA.
DR EMBL; AAMEML010000005; EDG5288115.1; -; Genomic_DNA.
DR EMBL; AAMEMP010000002; EDG5369241.1; -; Genomic_DNA.
DR EMBL; DAAMEZ010000009; HAC6380327.1; -; Genomic_DNA.
DR EMBL; DAAMHM010000008; HAC6681499.1; -; Genomic_DNA.
DR EMBL; DAAQQK010000002; HAE0433591.1; -; Genomic_DNA.
DR EMBL; UGVQ01000002; SUE47154.1; -; Genomic_DNA.
DR RefSeq; WP_001069113.1; NZ_WFIN01000004.1.
DR AlphaFoldDB; A0A0T7RYT0; -.
DR UniPathway; UPA00226; -.
DR Proteomes; UP000039541; Unassembled WGS sequence.
DR Proteomes; UP000042394; Unassembled WGS sequence.
DR Proteomes; UP000254190; Unassembled WGS sequence.
DR Proteomes; UP000839929; Unassembled WGS sequence.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004456; F:phosphogluconate dehydratase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0046177; P:D-gluconate catabolic process; IEA:UniProtKB-UniRule.
DR GO; GO:0009255; P:Entner-Doudoroff pathway through 6-phosphogluconate; IEA:UniProtKB-UniRule.
DR Gene3D; 3.50.30.80; IlvD/EDD C-terminal domain-like; 1.
DR HAMAP; MF_02094; Edd; 1.
DR InterPro; IPR004786; 6-phosphgluc_deHydtase.
DR InterPro; IPR042096; Dihydro-acid_dehy_C.
DR InterPro; IPR000581; DiOHA_6PGluconate_deHydtase.
DR InterPro; IPR020558; DiOHA_6PGluconate_deHydtase_CS.
DR InterPro; IPR037237; IlvD/EDD_N.
DR NCBIfam; TIGR01196; edd; 1.
DR PANTHER; PTHR43661; D-XYLONATE DEHYDRATASE; 1.
DR PANTHER; PTHR43661:SF1; PHOSPHOGLUCONATE DEHYDRATASE; 1.
DR Pfam; PF00920; ILVD_EDD; 1.
DR SUPFAM; SSF143975; IlvD/EDD N-terminal domain-like; 1.
DR SUPFAM; SSF52016; LeuD/IlvD-like; 1.
DR PROSITE; PS00886; ILVD_EDD_1; 1.
DR PROSITE; PS00887; ILVD_EDD_2; 1.
PE 3: Inferred from homology;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485, ECO:0000256|HAMAP-Rule:MF_02094};
KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277, ECO:0000256|HAMAP-
KW Rule:MF_02094};
KW Gluconate utilization {ECO:0000256|ARBA:ARBA00023064, ECO:0000256|HAMAP-
KW Rule:MF_02094}; Iron {ECO:0000256|HAMAP-Rule:MF_02094};
KW Iron-sulfur {ECO:0000256|HAMAP-Rule:MF_02094};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|HAMAP-Rule:MF_02094};
KW Metal-binding {ECO:0000256|HAMAP-Rule:MF_02094}.
FT BINDING 154
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_02094"
FT BINDING 221
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_02094"
SQ SEQUENCE 603 AA; 64639 MW; 468EF52353D41F6B CRC64;
MNPNLLRVTQ RIVERSQQTR EAYLARIEQA KTATVHRSQL ACGNLAHGFA ACQPEDKASL
KSMLRNNIAI ITSYNDMLSA HQPYEHYPQI IRQALHSVNA VGQVAGGVPA MCDGVTQGQD
GMELSLLSRE VIAMSAAVGL SHNMFDGALF LGVCDKIVPG LAMAALSFGH LPAIFVPSGP
MASGLPNKEK VRIRQLYAEG KVDRMALLES EAASYHAPGT CTFYGTANTN QMVVEFMGMQ
LPGSSFVHPD APLREALTAA AARQVTRLTG NGNTWMPLGK MIDEKVVVNG IVALLATGGS
TNHTMHLVAM ARAAGILINW DDFSDLSEVV PLMARLYPNG PADINHFQAA GGVPVLMREL
LNAGLLHEDV NTVAGFGLKR YTLEPWLNNG ELDWREGAER SLDNDVIASF DKPFSPHGGT
KVLSGNLGRA VMKTSAVPVE NQIIEAPAMV FESQHDVLPA FDAGLLDRDC VVVVRHQGPK
ANGMPELHKL MPPLGVLLDR RFKIALVTDG RLSGASGKVP SAIHVTPEAY DGGLLAKVRD
GDIIRVNGQT GELTLLVDEA ELAARQPHIP DLSASRVGTG RELFGALREK LSGAEQGATC
ITF
//
