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Database: UniProt
Entry: A0A0U1KRK0_9FIRM
LinkDB: A0A0U1KRK0_9FIRM
Original site: A0A0U1KRK0_9FIRM 
ID   A0A0U1KRK0_9FIRM        Unreviewed;       561 AA.
AC   A0A0U1KRK0;
DT   17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT   17-FEB-2016, sequence version 1.
DT   25-OCT-2017, entry version 14.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=SpAn4DRAFT_4911 {ECO:0000313|EMBL:CQR70046.1};
OS   Sporomusa sp. An4.
OC   Bacteria; Firmicutes; Negativicutes; Selenomonadales; Sporomusaceae;
OC   Sporomusa.
OX   NCBI_TaxID=411922 {ECO:0000313|EMBL:CQR70046.1, ECO:0000313|Proteomes:UP000049855};
RN   [1] {ECO:0000313|EMBL:CQR70046.1, ECO:0000313|Proteomes:UP000049855}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Sporomusa ovata strain An4 {ECO:0000313|EMBL:CQR70046.1};
RA   Murphy D.;
RL   Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CTRP01000001; CQR70046.1; -; Genomic_DNA.
DR   EnsemblBacteria; CQR70046; CQR70046; SpAn4DRAFT_4911.
DR   Proteomes; UP000049855; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000049855};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000049855}.
FT   DOMAIN      257    385       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      469    538       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     265    272       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   561 AA;  63749 MW;  F006E5BC819CE0FD CRC64;
     MLITITFCGK ISYEKGLNTI MSADTAYMAS IWQTALIHMK KAFIKPLFET WIKSTMPLSI
     NDNVIEIGTP KQFVKEWLES RYVPVIKAAL KAAANKDFEV IFINMDMDIE NVEEETALLT
     IEDPTIEVTP EHNILSEKTE IQPIIPEITE KPVSDNDALT TTDYLKYLDD IGDIPEAAAA
     LSSEISPPNT ADTDITDTTK SNIKKERYPN RPNINLPPIS EEFNLNPKYI FSTFVIGNSN
     RLAHAASLAV SEAPAQVYNP FFIYGGVGLG KTHLMHAIGH RIKENNPNSK VVYISSEKFT
     NELINSIISG NPENFRQRYR NIDVLLVDDI QFLSKKEHTQ EEFFHTFNTL HDANKQIIIS
     SDRAPREIQT LEDRLRSRFE WGLITDIQPP DLETRIAVLR KKAMMESLNV PNEVIVYIAS
     RIENNIRELE GALIRVIAYA SLNNQPIDID LATEALKDIF PDGRPKQITT DLIKDIVAAY
     FKLKLEDLSA KKRTRNVAFP RQIAMYLCRE LTETSLPKIG EIFGGRDHTT VIHAHDKIHR
     ERNSDTKLNN TIKDLIKRIE S
//
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