ID A0A0U2VCK4_9CREN Unreviewed; 417 AA.
AC A0A0U2VCK4;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=site-specific DNA-methyltransferase (cytosine-N(4)-specific) {ECO:0000256|ARBA:ARBA00012185};
DE EC=2.1.1.113 {ECO:0000256|ARBA:ARBA00012185};
GN ORFNames=EYM_04760 {ECO:0000313|EMBL:ALU11794.1};
OS Ignicoccus islandicus DSM 13165.
OC Archaea; Thermoproteota; Thermoprotei; Desulfurococcales;
OC Desulfurococcaceae; Ignicoccus.
OX NCBI_TaxID=940295 {ECO:0000313|EMBL:ALU11794.1, ECO:0000313|Proteomes:UP000060778};
RN [1] {ECO:0000313|EMBL:ALU11794.1, ECO:0000313|Proteomes:UP000060778}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 13165 {ECO:0000313|EMBL:ALU11794.1,
RC ECO:0000313|Proteomes:UP000060778};
RA Podar M.;
RT "Comparative genomics of Ignicoccus.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = an N(4)-
CC methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:16857, Rhea:RHEA-COMP:11369, Rhea:RHEA-COMP:13674,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:85452, ChEBI:CHEBI:137933; EC=2.1.1.113;
CC Evidence={ECO:0000256|ARBA:ARBA00001893};
CC -!- SIMILARITY: Belongs to the N(4)/N(6)-methyltransferase family. N(4)
CC subfamily. {ECO:0000256|ARBA:ARBA00010203}.
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DR EMBL; CP006867; ALU11794.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0U2VCK4; -.
DR STRING; 940295.EYM_04760; -.
DR REBASE; 133923; M.Iis13165ORF4760P.
DR KEGG; iis:EYM_04760; -.
DR PATRIC; fig|940295.4.peg.910; -.
DR OrthoDB; 38200at2157; -.
DR Proteomes; UP000060778; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0015667; F:site-specific DNA-methyltransferase (cytosine-N4-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR002941; DNA_methylase_N4/N6.
DR InterPro; IPR017985; MeTrfase_CN4_CS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR Pfam; PF01555; N6_N4_Mtase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 2.
DR PROSITE; PS00093; N4_MTASE; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:ALU11794.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000060778};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 25..77
FT /note="DNA methylase N-4/N-6"
FT /evidence="ECO:0000259|Pfam:PF01555"
SQ SEQUENCE 417 AA; 49279 MW; DD177BBCFFBB48D6 CRC64;
MALEVSFRQL VKSVPSTTYA THGLYMHPAK FIPHVVRFAL EKYSKEGDTV FDPFAGHGTV
GIEAKILNRN AVLWDLNPMS RVLALASMYD GELRKSDFIL KDDSGCEFVP SWSNIDYWYP
EEFLNYLSKL WGFWHYNIYE RYKDRNLEAK AFVLSIPLFK ITRYFSWADE KIAKTYRSKY
AKRKVESLLK GNWKAVLWNM YWKNVNVVIR KVSEFKRYRP HKIDVVIKTS WKNNDKLAIF
DSIVNKVDRH IDLLITSPPY LQAQEYIRSF KLELAWLGYN DRDLRELSSR EIPYNNPPET
NIRSNTYWSV REIIEGYNNK KLLKLYDAYF KSILGFFERN QDVVDTMAIF VGPVKVRTLR
VPIDEIIREH MEAHGWRHVA TYIDTIKSRR LFESRINPAT GILDERTPTE HLLVITK
//
