ID A0A0U2Z6T7_9BACL Unreviewed; 272 AA.
AC A0A0U2Z6T7;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=2,5-diketo-D-gluconic acid reductase {ECO:0000313|EMBL:ALS74892.1};
GN ORFNames=AUC31_06490 {ECO:0000313|EMBL:ALS74892.1};
OS Planococcus rifietoensis.
OC Bacteria; Bacillota; Bacilli; Bacillales; Planococcaceae; Planococcus.
OX NCBI_TaxID=200991 {ECO:0000313|EMBL:ALS74892.1, ECO:0000313|Proteomes:UP000067683};
RN [1] {ECO:0000313|EMBL:ALS74892.1, ECO:0000313|Proteomes:UP000067683}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=M8 {ECO:0000313|EMBL:ALS74892.1,
RC ECO:0000313|Proteomes:UP000067683};
RA See-Too W.S.;
RT "Complete genome of Planococcus rifietoensis type strain M8.";
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP013659; ALS74892.1; -; Genomic_DNA.
DR RefSeq; WP_058381599.1; NZ_CP013659.2.
DR AlphaFoldDB; A0A0U2Z6T7; -.
DR STRING; 200991.AUC31_06490; -.
DR KEGG; prt:AUC31_06490; -.
DR OrthoDB; 9804790at2; -.
DR Proteomes; UP000067683; Chromosome.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0071704; P:organic substance metabolic process; IEA:UniProt.
DR GO; GO:0044281; P:small molecule metabolic process; IEA:UniProt.
DR CDD; cd19071; AKR_AKR1-5-like; 1.
DR Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR InterPro; IPR020471; AKR.
DR InterPro; IPR018170; Aldo/ket_reductase_CS.
DR InterPro; IPR023210; NADP_OxRdtase_dom.
DR InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR PANTHER; PTHR43827; 2,5-DIKETO-D-GLUCONIC ACID REDUCTASE; 1.
DR PANTHER; PTHR43827:SF3; ALDO-KETO REDUCTASE; 1.
DR Pfam; PF00248; Aldo_ket_red; 1.
DR PIRSF; PIRSF000097; AKR; 1.
DR PRINTS; PR00069; ALDKETRDTASE.
DR SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
DR PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
DR PROSITE; PS00063; ALDOKETO_REDUCTASE_3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000067683}.
FT DOMAIN 18..266
FT /note="NADP-dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF00248"
FT ACT_SITE 51
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT BINDING 109
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT SITE 76
FT /note="Lowers pKa of active site Tyr"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ SEQUENCE 272 AA; 30444 MW; 3212BE87BEA3570E CRC64;
MANEKFFTSH NGVEIPTIGF GTWQIPNEEA YAAVTTALEN GYTHIDTALA YQNEENVGKA
IRDFNISREE VFITSKLPAE IKGYDATLAA FEETITNLGV DVLDLYLIHA PWPWDEVGKD
CTEGNIESWK AMEKLYKDGK IRAIGVSNFS EKDIQALLDS CDIVPMVNQI PFYIGRDQAS
LLQFCKKHNI VVEAYSPLAT GQILNSPEIK EMAAKYSVTP AQLCIRYCLE HGTLPLPKST
NKERIVENSQ LAFTISPEDV QKLDAFEDVR SK
//
