ID A0A0U4BR76_9BACT Unreviewed; 642 AA.
AC A0A0U4BR76;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Propionate--CoA ligase {ECO:0000313|EMBL:ALW86234.1};
GN Name=prpE {ECO:0000313|EMBL:ALW86234.1};
GN Synonyms=yahU {ECO:0000313|EMBL:ALW86234.1};
GN ORFNames=AUC43_14750 {ECO:0000313|EMBL:ALW86234.1};
OS Hymenobacter sedentarius.
OC Bacteria; Bacteroidota; Cytophagia; Cytophagales; Hymenobacteraceae;
OC Hymenobacter.
OX NCBI_TaxID=1411621 {ECO:0000313|EMBL:ALW86234.1, ECO:0000313|Proteomes:UP000059542};
RN [1] {ECO:0000313|EMBL:ALW86234.1, ECO:0000313|Proteomes:UP000059542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DG5B {ECO:0000313|EMBL:ALW86234.1,
RC ECO:0000313|Proteomes:UP000059542};
RA Shamseldin A., Moawad H., Abd El-Rahim W.M., Sadowsky M.J.;
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP013909; ALW86234.1; -; Genomic_DNA.
DR RefSeq; WP_068195209.1; NZ_CP013909.1.
DR AlphaFoldDB; A0A0U4BR76; -.
DR STRING; 1411621.AUC43_14750; -.
DR KEGG; hyg:AUC43_14750; -.
DR OrthoDB; 9778383at2; -.
DR Proteomes; UP000059542; Chromosome.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR CDD; cd05967; PrpE; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR032387; ACAS_N.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR43347; ACYL-COA SYNTHETASE; 1.
DR PANTHER; PTHR43347:SF3; ACYL-COA SYNTHETASE SHORT-CHAIN FAMILY MEMBER 3, MITOCHONDRIAL; 1.
DR Pfam; PF16177; ACAS_N; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 3: Inferred from homology;
KW Ligase {ECO:0000313|EMBL:ALW86234.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000059542}.
FT DOMAIN 7..61
FT /note="Acetyl-coenzyme A synthetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16177"
FT DOMAIN 72..448
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 513..592
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 642 AA; 69703 MW; 38B09AB0B1936EF7 CRC64;
MKPACSYAAT HAASLADPAA FWLRQAAHLH WDTPPTRPLS QDAQGFYRWF EGGELNTSFL
CLDYHVQHGR GAQPALIYDS PVTNTLRTYT YAELLDMTER FAGGLRAIGV GLGDRVIIYM
PNMPEAVVAM LACARIGAVH SVVFGGFAPH ELAVRIDDAK PHAIICASGG MEFDRIIPYK
PLVDEAVAKA THKPAHVVVC QRDFVTATLQ PGRDLDYRKL LQAPPIAALP VPATHPLYIL
YTSGTTGRPK GVLRDHGGHA VALRFSMEAI YDLAPGEVMF TASDIGWAVG HSYIVYGPLL
RGCTTVLYEG KPVRTPDAGA FWRIVAQHRA RVMFTAPTAI RAIKKEDPEG RLAHKYELSC
LRHLFLAGER CDPATFAWAQ QVLGVPVVDH WWQTESGWPM LATLVGLEGM PPPRPGSAGH
PVPGYDVQIL DEAGEPVTAG TTGLVAVKLP LPPGCFPTLW NDDARFHEAY LATFPGYYLS
GDGGYRDSEG YCYIMGRVDD VINVAGHRLS TGEMEEILAA HPAVAECAVL GIADSLRGQV
PVGLVVLKDG QTIGEEALEK ELVATVRARI GPLACFRTVL VVKRLPKTRS GKILRKTLRQ
LADGEAFAVP STIDDPLILD EIRAGLQRRA VGLAYEASHP SQ
//
