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Database: UniProt
Entry: A0A0V0QEE5_PSEPJ
LinkDB: A0A0V0QEE5_PSEPJ
Original site: A0A0V0QEE5_PSEPJ 
ID   A0A0V0QEE5_PSEPJ        Unreviewed;       836 AA.
AC   A0A0V0QEE5;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   15-FEB-2017, entry version 6.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=PPERSA_12805 {ECO:0000313|EMBL:KRX00586.1};
OS   Pseudocohnilembus persalinus (Ciliate).
OC   Eukaryota; Alveolata; Ciliophora; Intramacronucleata;
OC   Oligohymenophorea; Scuticociliatia; Philasterida; Pseudocohnilembidae;
OC   Pseudocohnilembus.
OX   NCBI_TaxID=266149 {ECO:0000313|EMBL:KRX00586.1, ECO:0000313|Proteomes:UP000054937};
RN   [1] {ECO:0000313|EMBL:KRX00586.1, ECO:0000313|Proteomes:UP000054937}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=36N120E {ECO:0000313|EMBL:KRX00586.1};
RX   PubMed=26486372; DOI=10.1038/srep15470;
RA   Xiong J., Wang G., Cheng J., Tian M., Pan X., Warren A., Jiang C.,
RA   Yuan D., Miao W.;
RT   "Genome of the facultative scuticociliatosis pathogen
RT   Pseudocohnilembus persalinus provides insight into its virulence
RT   through horizontal gene transfer.";
RL   Sci. Rep. 5:15470-15470(2015).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KRX00586.1}.
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DR   EMBL; LDAU01000184; KRX00586.1; -; Genomic_DNA.
DR   EnsemblProtists; KRX00586; KRX00586; PPERSA_12805.
DR   Proteomes; UP000054937; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000054937};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054937};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    426    449       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    469    486       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    535    554       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    566    590       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    634    651       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    772    790       Helical. {ECO:0000256|RuleBase:RU361189}.
SQ   SEQUENCE   836 AA;  96914 MW;  53D2ED56530877AA CRC64;
     MGLLRSENMG LYWLKMPRES AYDIISALGR LSCMQFIDAD EYDTPGFQRH FHNNIKRSEE
     VLIKIQEIIA EINLFDLETT KCGNYYGYLE NLDQTLNKYN KSHARYFDDI EADIDKKYIY
     MNQLINNFSA SVEQRNQFIE QRAVYQMAGK IYNSQNQMQE NLGRNLLSCI AGTIDLKDQE
     RFQRTIFRVS KGNSIAIIEE ISKDQRKNQQ LINGKTRQII QKAVFIIMFA GSSSGYFRQR
     LLRVCDSFGA NMVNLPTDLK SQQQLYIQTE KKIQEINEMV TLNENEIEKF FRHLTFVDRQ
     IENKPNQQLG SLCSEIEFAK LYCIREKLIY QQLNLLNQTN SIYQGLVWIE ESLVSMVARK
     LSDLSKANPN LAMGQIFNVE EYNIEPPTYI KTNDFTQSFQ EIVNTYGVPR YKEANPGLLT
     TMTFPFLFGV MYGDIGHGSV LFIFALYLLS MTPNLAQPGP LDGLYKHRYL IFFMGLFAVF
     CGFIYNDFFG FQLNLFGTCY DNQLEKNETC TYLFGVDPVW GIAKNKLTFF NSLKMKLSVI
     IGVIQMMVGI FLKGMNSIYF GSSIDFFFEF IPQLIFLTCT FGYMCFQITL KWLYDYSSDY
     SLAPSILTNM MKFFLGLGAT DPDFADLYQN QSQIQFYLLI AAVISVPLML FPKPLIQSHI
     HGKNVNKNMH DQKAGYLQFV DEDEEDRLQK QLEQGGKQQQ QKICPYRKEI EHHEFSEEFV
     HQMIETIEFV LGCVSHTASY LRLWALSLAH SQLAEVFFDK TLKGALVSGD TSLIVVGFVI
     FACITFGVLM CMDTLECFLH ALRLHWVEFQ SKFFKADGYK FQAFSYVQML AEHENQ
//
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