ID A0A0V0QNX4_PSEPJ Unreviewed; 645 AA.
AC A0A0V0QNX4;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Histone deacetylase domain-containing protein {ECO:0000259|Pfam:PF00850};
GN ORFNames=PPERSA_04746 {ECO:0000313|EMBL:KRX03868.1};
OS Pseudocohnilembus persalinus (Ciliate).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Scuticociliatia; Philasterida; Pseudocohnilembidae;
OC Pseudocohnilembus.
OX NCBI_TaxID=266149 {ECO:0000313|EMBL:KRX03868.1, ECO:0000313|Proteomes:UP000054937};
RN [1] {ECO:0000313|EMBL:KRX03868.1, ECO:0000313|Proteomes:UP000054937}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=36N120E {ECO:0000313|EMBL:KRX03868.1};
RX PubMed=26486372; DOI=10.1038/srep15470;
RA Xiong J., Wang G., Cheng J., Tian M., Pan X., Warren A., Jiang C., Yuan D.,
RA Miao W.;
RT "Genome of the facultative scuticociliatosis pathogen Pseudocohnilembus
RT persalinus provides insight into its virulence through horizontal gene
RT transfer.";
RL Sci. Rep. 5:15470-15470(2015).
CC -!- SIMILARITY: Belongs to the inositol phosphokinase (IPK) family.
CC {ECO:0000256|ARBA:ARBA00007374}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX03868.1}.
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DR EMBL; LDAU01000124; KRX03868.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V0QNX4; -.
DR EnsemblProtists; KRX03868; KRX03868; PPERSA_04746.
DR InParanoid; A0A0V0QNX4; -.
DR OMA; EASEHTI; -.
DR OrthoDB; 124800at2759; -.
DR Proteomes; UP000054937; Unassembled WGS sequence.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:InterPro.
DR GO; GO:0032958; P:inositol phosphate biosynthetic process; IEA:InterPro.
DR CDD; cd09992; HDAC_classII; 1.
DR Gene3D; 3.40.800.20; Histone deacetylase domain; 1.
DR Gene3D; 3.30.470.160; Inositol polyphosphate kinase; 1.
DR InterPro; IPR000286; His_deacetylse.
DR InterPro; IPR023801; His_deacetylse_dom.
DR InterPro; IPR037138; His_deacetylse_dom_sf.
DR InterPro; IPR005522; IPK.
DR InterPro; IPR038286; IPK_sf.
DR InterPro; IPR023696; Ureohydrolase_dom_sf.
DR PANTHER; PTHR10625:SF4; HISTONE DEACETYLASE 6, ISOFORM G; 1.
DR PANTHER; PTHR10625; HISTONE DEACETYLASE HDAC1-RELATED; 1.
DR Pfam; PF00850; Hist_deacetyl; 1.
DR Pfam; PF03770; IPK; 1.
DR PRINTS; PR01270; HDASUPER.
DR SUPFAM; SSF52768; Arginase/deacetylase; 1.
DR SUPFAM; SSF56104; SAICAR synthase-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000054937};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 26..324
FT /note="Histone deacetylase"
FT /evidence="ECO:0000259|Pfam:PF00850"
SQ SEQUENCE 645 AA; 74682 MW; 71A4245CBFB1574E CRC64;
MQKSEKKVYL IYEQEKTSLH RIQRPHIENP QRIESIIQNF KEKGILDHSV IYSENSIQEK
IDKKQILKVH TEDYYNFIEG MWPEDTEKEQ IMVKDCYINQ HTFDSSLWAA GGVLQAMQVV
AEGKFKHSLS ILRPPGHHSG ASPVCHGFCF FNNVAIAVQH LKQEFNMKKI LIFDWDIHHG
DGTSQIFQND KEVLYMSIHK YDNGLYFPKT GHPQDVGQNE GKGYNVNIGW NTQQNLIPGT
DEYIYVFEQI CLPIIKQFNP ELIVVSAGFD AALGDPVGKC KLTGIGYSYM LQKLLEIQEK
TVVVLEGGYS LDALQEASEH TIRTLMGEKL GESQHFKNIL HNQQNLKNID DYKKNILPSP
LAFKAVEESV QHLAQYWPCL KEDKEIQEFE KYVKKHLKVQ SQIGAGHKDK LKFEGKSIVK
KTKKQEIHFY ESLDDETHSC FEENQKLKAF IPAYLGKFAE NEKDIGIILE NLLVNKEKGS
FLDIKFGQVT FEKSLDEKKY EQDVKKSKET TSHELYYRLS AAKIKDKEGN IIESIDKFGG
TKENMPFIFK KVLQSNEQQN INQQALDELI DFLERYIQFQ ENHSTRRFLG TSLFFVVDNT
TNQFAMKIID FNYYFPMEQG QIDTNVIPGL KNIKQLLLDL KESEK
//
