ID A0A0V0R514_PSEPJ Unreviewed; 1779 AA.
AC A0A0V0R514;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Ribonuclease H-like domain {ECO:0000313|EMBL:KRX09581.1};
GN ORFNames=PPERSA_08613 {ECO:0000313|EMBL:KRX09581.1};
OS Pseudocohnilembus persalinus (Ciliate).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Scuticociliatia; Philasterida; Pseudocohnilembidae;
OC Pseudocohnilembus.
OX NCBI_TaxID=266149 {ECO:0000313|EMBL:KRX09581.1, ECO:0000313|Proteomes:UP000054937};
RN [1] {ECO:0000313|EMBL:KRX09581.1, ECO:0000313|Proteomes:UP000054937}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=36N120E {ECO:0000313|EMBL:KRX09581.1};
RX PubMed=26486372; DOI=10.1038/srep15470;
RA Xiong J., Wang G., Cheng J., Tian M., Pan X., Warren A., Jiang C., Yuan D.,
RA Miao W.;
RT "Genome of the facultative scuticociliatosis pathogen Pseudocohnilembus
RT persalinus provides insight into its virulence through horizontal gene
RT transfer.";
RL Sci. Rep. 5:15470-15470(2015).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX09581.1}.
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DR EMBL; LDAU01000046; KRX09581.1; -; Genomic_DNA.
DR EnsemblProtists; KRX09581; KRX09581; PPERSA_08613.
DR InParanoid; A0A0V0R514; -.
DR OrthoDB; 463649at2759; -.
DR Proteomes; UP000054937; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:InterPro.
DR CDD; cd07521; HAD_FCP1-like; 1.
DR CDD; cd09279; RNase_HI_like; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR004274; FCP1_dom.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR002156; RNaseH_domain.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR46387; POLYNUCLEOTIDYL TRANSFERASE, RIBONUCLEASE H-LIKE SUPERFAMILY PROTEIN; 1.
DR PANTHER; PTHR46387:SF2; RNASE H DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF03031; NIF; 1.
DR Pfam; PF13456; RVT_3; 1.
DR SMART; SM00577; CPDc; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50969; FCP1; 1.
DR PROSITE; PS50879; RNASE_H_1; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000054937};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 316..347
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 359..382
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1210..1353
FT /note="FCP1 homology"
FT /evidence="ECO:0000259|PROSITE:PS50969"
FT DOMAIN 1638..1770
FT /note="RNase H type-1"
FT /evidence="ECO:0000259|PROSITE:PS50879"
FT REGION 126..178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 489..509
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 989..1020
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1062..1081
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1489..1508
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1524..1589
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1123..1189
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1779 AA; 210172 MW; A678C2C42DA4056E CRC64;
MQDKDISQQA QTILEDFVQL KKQTFYSKRF ITVNSEGYFI YYKDESRKEL RGNYNLQEFE
IKKSDKKNEE NREQVYGKEK QKEIEKLKNS YENIINSYNN NGYLKGDQTE QKEFYLEYNS
DFQTQKQSSS MKSYQKYNND NSSHLPKNNT STLVNEKSSN SISGVSQQQS QLQQSGKVIS
SQNTIYHNQS QTQKQQEQQK QKGQKKEILP QFKKLVIVEQ NYELQQQNKK ESLYQKIDRG
KFLSFFDKQF ANKNNISYKS ENYYTYDENI DLKQKGEIKQ KIDDFLSNFI RNRFFLTDVD
SCGLKIFTQK KQVSKFGLVF GTLVSGFYLG IYLALILAYL YFVYLVFHIP IINDNKAGFA
TIIVPVLGFL FYMIMVPVFV FIDKYGQRSM KMVSRVQKRL NQSKDAEFKD KKSFINCEIK
QGDQYRVISE KYLNCGINEV LFALTNLNYE NRKEFSPLLS DLQYDKSQSN YKNMNIFNCY
YGNQQKKENG NQNQNHLQLQ QNGDGKSDQN FEQKQYNQQV VIEVMKKISK EKLQEQKEQG
ADYKDILYYI AEFGYVKGEI YILRLYKIER FDIESCLITY YGENEWNKNI IQKQDQQKNQ
KKMSFLEQKR AECKFLVEVL KIQDGVSAYC LKDLEKLILK QKSQIFSDYN LYLQEKYDQI
NIIDQKERNE EIQELEKQLQ IAITEQKQSI PNKNQNNQTF ELNAQNIEKT INMAKNVETT
INMAKNVKKA QVQAPKLSPR YSSPFHNNNN FDNLQGKKIQ VQLNNINKPY ILAENQNRHK
NENGNKNNKN VVELNQQPNN INKNIEIQLK NNEQNLSKKN NIANQQKQIQ IAKNGTGNQE
IDQNIQQVSQ IKNIAIQQQN ANISQKNNFN NIINNDNQQK QQSKNFQPQS ITQQLQMKKK
QIDQQFLQGP VSQQQNQQLQ QKDEQQQQFL QKQDKIAFQN AYNSNNNKNI QNLNLISKSQ
NFGQELFDVQ RQSVPNFVSY QNFNNLGQNS QKQQKSDLQE NNNINNNQNN QIQQSQKPDK
VQIMPKYSPL KNENYLVNKG MHMHNNEFEE LQSQSLNLGK YGLNSFSSQT SPSTPVKQKN
QNQTFLGPNL QVSQQQLFLN QGKSQVQNQQ QKQQIQEWVD QDEAQLKNEN EKILIQNRNI
QNQQSNQNNQ NKQNRQNIQN LQNQEEKSKF DLTNQKQTIN KNIQNYKEQA ARSKSPLVNE
GQGLKKLPRD SKKIYTLVLD MDETLIHTFD FSSADYGFYR RPYCTEFLNQ LSQHYEIVVF
TAAQKDYADK VLNCIDREGA ISHRLYRDHL FFNNMRKVKD LRILGREMSK TIIVDNLKEN
FELQPENGFH ISDFRGHKHD KELDYLMKFL LQIAQNQVQD IRPHLKQATN FIEKLRNLDK
NQRLNKSLDP KQQLKNQQQQ QQYYVVMSKL MKPKLVKTKQ TLQKYQDIDN NLYVKTFYDM
NQAQQFYDPL KDMYNQIYKT EKDFKTLEKE YKHKFLIQNE QQKIQEAKLS ESQKLEQKSQ
NKIDTNDECE KTGKIKNTLQ NEDKKTTKKY VKKESDIKQK NQEQDIQEDE KLVQKEEKDE
KNVKKEENNL KEQEKESKEQ QQQFKKKDQQ FGNKDNFEFS KQASEEDQKK FNKFLMYFYK
HDIKLFEKGK QIVQQYGENS NYVMFFDGAC QGNPGLSGAG YIIKTGSNQV VFKNSLFLGL
PRTNNQAEYF GFIYGLYSCF LLGIKKIDVF GDSQLILKQV GGEYRVKKAE LKPFHELAMN
LYNSFDQIKL GHIDREFNFE ADELSRKTIK YSYGSKKNK
//
