ID A0A0V0RST6_9BILA Unreviewed; 1005 AA.
AC A0A0V0RST6;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE SubName: Full=Transient receptor potential cation channel subfamily V member 4 {ECO:0000313|EMBL:KRX17480.1};
GN Name=Trpv4 {ECO:0000313|EMBL:KRX17480.1};
GN ORFNames=T07_6262 {ECO:0000313|EMBL:KRX17480.1};
OS Trichinella nelsoni.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6336 {ECO:0000313|EMBL:KRX17480.1, ECO:0000313|Proteomes:UP000054630};
RN [1] {ECO:0000313|EMBL:KRX17480.1, ECO:0000313|Proteomes:UP000054630}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS37 {ECO:0000313|EMBL:KRX17480.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX17480.1}.
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DR EMBL; JYDL01000087; KRX17480.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V0RST6; -.
DR STRING; 6336.A0A0V0RST6; -.
DR Proteomes; UP000054630; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR024862; TRPV.
DR PANTHER; PTHR10582:SF2; INACTIVE; 1.
DR PANTHER; PTHR10582; TRANSIENT RECEPTOR POTENTIAL ION CHANNEL PROTEIN; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF13637; Ank_4; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR SMART; SM00248; ANK; 3.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|EMBL:KRX17480.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000054630};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 452..472
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 484..507
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 528..551
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 599..618
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 671..693
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 300..332
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 453..707
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 32..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 837..912
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 930..967
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 983..1005
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 41..56
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 837..854
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 930..962
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1005 AA; 115476 MW; 95055E13D4E0AB31 CRC64;
MHCVQLSRPA NTSSSSSGQL ENFIFSKFKA AAEADAPKQS TSTSPPPPPP PPALVAPPLI
ICWRQSSSPS DTDQVIPIWR YHDRKPADPD SKWTNLSREY ERNNIYKWLQ RKKPGSLIEI
YEQEGRDGVL RFAEEKIVPM LHNEGQHPEI VREIDYIKWR KFMSTNLNEN AEKEDKDQEI
MQSIQFQEHQ ALWRLNRRGV KGETLAHLLL SSNEQRCAEI ARILICEYPH LSLDIYEDEE
MYGQSCLHLA ILHNDYDTAC LLLQCGASAV QRATGRFFWP NENGTSAAKE STQYEGLAYF
GEYPLAFAAS FGNKDIYDAL IDFNADPNAQ DTYGNTVLHM CVIHNSIPAD TTIVNGSGCT
PLSLATRLGR KEIFEEMLEL SGVEFWRFSD ITVSAYPLAA LDTINADGST NWDSALMNII
QGNTADHTEM VQGDVVQRLL ADKWRNFGWR HLFRWAIMFV LHLCSLSAAI YLRPTDGRFF
DYSGIYGICR AVAEATTVTG SLVFIFYQCF AEMLMQGFNY YLLAFRNSFV KIVFLIENVL
VILCIPCRVL GYVNVEEVLL VLVAPSSWMM LLYFARASIL TGPFVHIIYS MITGDMMRFA
LLSSVFLLSF GLVFNVLGQN MIELQELNYC SISGREKKSS YTTYGETILT LFRAAMGGYE
YEQLECSYYS VLLKILFICY LVVMPIMLIN MLLAMMGNTY TTIISQAEKA WRFQLAEMVI
RLERYYSKEK LAQFQLNYSI KMGEDRDTGM EKRGLMVIKQ FRKTRAQQRK LALTNWKNLY
RKYMDYRKEY GVEKARNIIW HGNWANNSDW RKKGPVNQKS ESTEMVLSTK KYDISRAGSK
EKLTSNHVSG DQKSKEEEEE EEEEAEEAEK NHKAEQQQRA VSMYESAKID QIPQPPSLAK
NNNKREEMNS METRLSEKWN YILTQSQLAA KEQQQQQQNS RRVRWTRPTN LSTTSLQNDQ
PKEKPIYAQR RSIYFTNIFK SQKESNNVST ELKTNPPSSS TNLPV
//
