ID A0A0V0S3D1_9BILA Unreviewed; 944 AA.
AC A0A0V0S3D1;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 22-FEB-2023, entry version 22.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN Name=EIF4A3 {ECO:0000313|EMBL:KRX21188.1};
GN ORFNames=T07_10049 {ECO:0000313|EMBL:KRX21188.1};
OS Trichinella nelsoni.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6336 {ECO:0000313|EMBL:KRX21188.1, ECO:0000313|Proteomes:UP000054630};
RN [1] {ECO:0000313|EMBL:KRX21188.1, ECO:0000313|Proteomes:UP000054630}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS37 {ECO:0000313|EMBL:KRX21188.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the NPL4 family.
CC {ECO:0000256|ARBA:ARBA00011025}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX21188.1}.
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DR EMBL; JYDL01000041; KRX21188.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V0S3D1; -.
DR Proteomes; UP000054630; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0043186; C:P granule; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR CDD; cd18045; DEADc_EIF4AIII_DDX48; 1.
DR CDD; cd08061; MPN_NPL4; 1.
DR CDD; cd18787; SF2_C_DEAD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR037518; MPN.
DR InterPro; IPR016563; Npl4.
DR InterPro; IPR007717; NPL4_C.
DR InterPro; IPR007716; NPL4_Zn-bd_put.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR PANTHER; PTHR12710; NUCLEAR PROTEIN LOCALIZATION 4; 1.
DR PANTHER; PTHR12710:SF0; NUCLEAR PROTEIN LOCALIZATION PROTEIN 4 HOMOLOG; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF05021; NPL4; 1.
DR Pfam; PF05020; zf-NPL4; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS50249; MPN; 1.
DR PROSITE; PS51195; Q_MOTIF; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Initiation factor {ECO:0000313|EMBL:KRX21188.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000313|EMBL:KRX21188.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000054630};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 891..911
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 40..68
FT /note="DEAD-box RNA helicase Q"
FT /evidence="ECO:0000259|PROSITE:PS51195"
FT DOMAIN 71..250
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 261..422
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 541..678
FT /note="MPN"
FT /evidence="ECO:0000259|PROSITE:PS50249"
FT MOTIF 40..68
FT /note="Q motif"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00552"
SQ SEQUENCE 944 AA; 107752 MW; 5762C75381F0974A CRC64;
MARVFTSKEF RRKRRLQDDF EEEDMSRVDF ETSENVVVIP TFEEMNLKRE LLRGIYAYGF
NKPSMIQKRA IRPIVSGRDV IAQSQSGTGK TATFSIGLLQ VIDTQLRETQ ALVLAPTREL
AQQIQKVVLA LGDRMNVQAH ACIGGTNVGE DIRKLDYGQH VVVGTPGRVF DMITRQNLRT
DSLKVFVMDE ADEMLTKGNE LLYLILGFKD QIYDIYRFLP PGIQVVVISA TLPHEILEMT
GKFMTEPVRI LVKRDELTLE GIRQYFVHVE REDWKFETLC DLYDSITISQ AVVFCNTRHK
VEWLDEKMKE SNFTVGAIHG EMEQKDRNEV VRKFRDGIYR VLISTDVWSR GLDIPGVSLV
INYDVPTNRE AYLHRIGRSG RYGRKGCAIN FATTEDIPTM LEIESYYGTQ IDEMPMNDIL
VNRLVLAATK NGIRNVQESI SYINIDRPFS AMKLKKDVEE DLVDQILEKQ SGANMVIRRN
AVTVCQYIIR SAASIPSLEK VSCQIIPNCR NHLPWPQGIC SKCQPNPVTL NHQRYRHVDN
VEIENKEIMS NFLSYWYKSH GQRMGFLFGR YEPMTDVPLG IRAVVTVIYE PPQITYTDGI
DILEDPHDEI VDSLAECLGL KRIGWIFTDF LRDPDDPTLL VNTRNANTYM LSAAECLIAA
KYQNKYPNAC KYSLDGTFGS KFVTLVLSAY QVSNQGSALV AAECLLPSRS SPNMACVRRS
TPTHYVPDVY YMCHDEYNNK IRKTAGLLPV EYLFVTIPVG LAKEMRYTLT SQKKPFPIEN
RSSIGCAQNI RVVGEYVKQF EESEFLKMIS NFHFLVYLLT NTEVTFELDD LAELLDAVAK
QDSDLAKQWA ENSIKWNEFK NLIGKFSFRL FIMVDLDGSQ SPHSHKISNT VFIIPAVIVL
IIVGIVVYKL INTLQSKHKK KEEKKKAKGK QNASEITIGI MQKL
//
