ID A0A0V0SG50_9BILA Unreviewed; 4862 AA.
AC A0A0V0SG50;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Midasin {ECO:0000256|ARBA:ARBA00017143, ECO:0000256|PIRNR:PIRNR010340};
GN Name=MDN1 {ECO:0000313|EMBL:KRX25714.1};
GN ORFNames=T07_12822 {ECO:0000313|EMBL:KRX25714.1};
OS Trichinella nelsoni.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6336 {ECO:0000313|EMBL:KRX25714.1, ECO:0000313|Proteomes:UP000054630};
RN [1] {ECO:0000313|EMBL:KRX25714.1, ECO:0000313|Proteomes:UP000054630}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS37 {ECO:0000313|EMBL:KRX25714.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Nuclear chaperone required for maturation and nuclear export
CC of pre-60S ribosome subunits. {ECO:0000256|PIRNR:PIRNR010340}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}. Nucleus, nucleoplasm
CC {ECO:0000256|ARBA:ARBA00004642}.
CC -!- SIMILARITY: Belongs to the midasin family.
CC {ECO:0000256|ARBA:ARBA00007188, ECO:0000256|PIRNR:PIRNR010340}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX25714.1}.
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DR EMBL; JYDL01000011; KRX25714.1; -; Genomic_DNA.
DR STRING; 6336.A0A0V0SG50; -.
DR Proteomes; UP000054630; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd00009; AAA; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 6.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR040848; AAA_lid_7.
DR InterPro; IPR011704; ATPase_dyneun-rel_AAA.
DR InterPro; IPR012099; Midasin.
DR InterPro; IPR041190; Midasin_AAA_lid_5.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR48103:SF2; MIDASIN; 1.
DR PANTHER; PTHR48103; MIDASIN-RELATED; 1.
DR Pfam; PF07728; AAA_5; 7.
DR Pfam; PF17865; AAA_lid_5; 1.
DR Pfam; PF17867; AAA_lid_7; 3.
DR PIRSF; PIRSF010340; Midasin; 4.
DR SMART; SM00382; AAA; 5.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 6.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR010340};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|PIRNR:PIRNR010340};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR010340};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR010340};
KW Reference proteome {ECO:0000313|Proteomes:UP000054630};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 4714..4733
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 4635..4852
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 4057..4135
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4180..4354
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4385..4408
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4438..4463
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4073..4089
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4090..4122
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4180..4221
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4222..4263
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4274..4348
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4447..4462
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4862 AA; 554530 MW; E85FB38FE1A385AC CRC64;
MESSQQHAEV DADEKLNQYV ENCVEDVANL DSQMSCMKEL IPVVQDARFF ARRLIEKISG
NEFRKPEMES EIVELIWLLF NYDTEYCVHK FDRFNFVKFL PKHKHLVIQF FAIAALRIAG
IFHQFSEDLY TDFRWSDVDL RIIQYYFKGS RLSETLKFLT RQPTSAIMQF LNESPLKKLR
GAECKCCVES RNLDIFNNDE YYMQMANAIY EEKVLVVYGP GGCGKSWLLR SFAHSVKRCR
DLVVLQLSEQ MDVKACFGGY VCTEVPGEFC WQLGAIGEAA KMGRWLLLED VDCSPVELLH
QLGAMIENRQ LLVDNLNGKF ELHSNFRLIF TSSADYENLQ RKIGVLHKYC HFLEMKQANF
AELASAIFED KTKNEMMNLI FSNLLTLPLD AKVSPVTLRS LLKMRRRLES NAVDALTEAK
LKDCFLDLDD CFLASIQSKA VRSSVRSELA EKFGQNIVKY EKTRRPLVQL KSDGINIGRV
YLKKHTENMK WKYEFFYTSQ ACNLLEKIAR GVSLSEPFLL VGETGCGKTA AVQFLAERLG
VELTIINMSQ QSEITDLIGG FRPCGPEFFF NDLLKRFNSV RLLPNIGRES LAESINQDFQ
KKEWKNAICK MEWAVRFTAE KCQPNDPSLH DFLDYLQKLV KSADKMKHIA PFRYVKASKL
VHHFALVVEL GSKQINKQTN KNCIFKIQGA LAKAVELGKW LLIDEINMAS PELLNALHFL
LDCRAGDQVL LDPSQKEMIT VHENFRLIAC MNPATDVGKR ELNPGLRSRF TEVFVDELDS
LEDLRMLTRA YLDRNKHWSI TVNVIESLVK FFVQIKSISS SLSSGFQSAG PCYTLRTYCR
ALMDASENRF HYTWRSLYEA FCLSFLTELD ASSYETVKKM IFEYTVRKCS SIPDLKSLLS
RCSVISDSRC VAICGYQLVR GSAEVNVDPS YVLTDTVKRN LEDLCRAVSS RKFPVLLQGE
TSVGKTSLIN YLANCTGNVC MRINNHQNTD IQDYVGSYIN DASGQLVFVE GPLVKAMRNG
HWIILDELNL ADSDVLESLN RVLDDNRELF IMETQEVVKA HPNFQIFATQ NPPGLYGGRK
SLSRAFRNRF VQMNFGELPY NEIETILQMR CGLPLSYASK MVAVMKELQA NRSSCSMFAG
REGYITLRDL FRWGDRFKNV SAQQNDYIQY LAEQGYFILA GRCRRSEDEK VVIENLETCF
KVKIDLDKLF HIDSPYFPLG LLDIRNNVEE FKHICWTKSI VRSAVLLGQA LQFNEPTLLV
GDTGCAKTTL CQMFAKANSR SMNTINCHMS TEAADFVGRL VPAPLECQER MSMFFYWLDG
PLVKSMKKGE YFLIDEISLA EDAVIERLNS VLEPERTLTV YERIGCAQPR TVSSAPGFNV
LATMNPGGDY GKRELSRALR NRFTEIWCKT TSLQACEEQE DMIELLSQNL PVEDDLLRNA
LAKCMLDFLR QIDSRMPKEF SMRDVIAWLQ FIKANVGMLD VALSIVHGAI ATVIDSFGAK
GAAVSVEERK KFGDDVFEHL LKSLESQLGR VNRSKLLNAH ITNHEDHLQI GCFTVAKGSK
QCSTETTIID AFGMRTYDFF RLARALSVQR PILIQGSPGV GKSTLVMEFA ALTGHRIIRI
NLSEQTDLCD LFGSEFPIMN DKSRQMFTWL DGPLLAAVKK GYWVLLDEMN LASQTVLEGL
NACFDHRGEI TIPELGKTFS VGTTATRFFA CQNPYNQGGN RKALPKSFVS RFTLIHLNNL
TETDQLEIMR HKFTNIEGHV LKNMVTFNSK LNVMVRQQGF ESFASGNAEF NLRDLIRWGK
LISVTGLPYE KLFYTVYAVR MRDYEERLKV MQLFVETTKT NFQKETLDTF VITNNKLYFG
DAVLDRREAY VYLGNVTCDA VMPPMSLASY YKYLMQCIQG NMLAILVGKS MVGKTMLVKT
LSLLCRQKLT ILNLTPETDA SELLGTYEQE TTGRKCFRHF VRRMKAACEN LALETYIYGC
LYAFEKLLSL LLELDDVQKL NLNHCKAMLE KLQTIGNVFI GFTSLKAKFN DSVNGLQRIL
CRCTSESDNV RFVWVESPLL VALREGHWLL VENVNLCNPA VLDRLNSLFE PSGQLSVAER
GLFDNQLSIY KPHDQFRAIF TMDPKYGEIS RSMRNRAIEI YIPENDGWHN LHESEGGRLV
KLFSMNNNVF TDTKIGDCEL ISCSIPLNIL SAFPKAFALG RDLHFIRQVF AEVKQNKLDT
SVMQVVLRHY CCTSTTGDSA YRLPYMKKLF KECDAWLSGA KLNNLQILMQ KIPRIMSNSI
ERHSALEIMQ IMHFGATDLR WYFMRWFERL CESNVVFEDI SCILNKILFI IEYFWIYDVY
LCKVDSTILD ELEKEFENGE FSTHHNMNIF TWLSEFMRCI LGNYRNILSR RVIFPDSLWM
TASRSLLLLA VLCEKLRDMD IVQVKSSSLL LWHLCFDLRF TLLEVMNSTG LLYGLKGLSS
WKKLNPIRKD HAFILNFFDL LFNSLELSRC LYKAESALAI CELKRQMVCM KLLAKLKLVN
SEKLMANIEI FHNNAHLPYD KLNPVDIKQL LTLAEVELES VGNNFQKLFM LICFVESAEE
FYGKFHACCS VGCKNHPQIS LDDFPIDTVY DWLSFASTLI GEFRCSSPFR LALGYKEELK
NYLNDMLQLE NSKQFKSLLN IGNIRSMRSK ANEAMSFLWN CGSSLEMMPK LAAIVLHQTV
LTLSMKFLNA HSGLMWQKLD SPPYKTAMRT IKRTVTSYSD DTTLCPFGLY CICLSAGEAM
FTIYSLVVLY SKDPLKIACA KREAIDLQIA YVKKELKVFD KRFHMYWGSD LSGESSVHPR
VDSLRKLSTE LHKERQPLEK YCDFPKEREG ILQKLRMVFE NVLEKQNLIT KIFFDLKKIS
IKHGKMIGKQ DTVRELLDSL CLYKALMETT MRRLRDFLDL APDLVLHMQT SIQVIFLACE
GLLHELDCFL KRSQYTNKPE PKSEIANMCS WVNSSLPFPS KSALAIWENE NADKFDPAQF
FIDNPVRLER RAKAVRVLMR TWRDERSGFQ THPNVSWFKV DRVGVEVESS SSSSDGHEAE
EKRMVYLFEP WRNADDADDH LLKKKKCIVD AMRAVVLRHG GDDISGDGPM WDRLRGCLGE
IESDCFQLEN ILLMIDHYYK KDDDDDCRQS GERFFNAIYG EITYKEAVMV HDATDNFKTA
IHNLTLKHPE NVVLENILKS VENLQNCPYN STVATVQFAI GDILRKAVDW NVYVQSEMDE
FKAVCAELQE LYVHFSARQF HLWENLLEQT EIDASCNGVE HSMHVVDSLI HTSNYSVELG
VVEILSLIKS VGIGCFVDFI KALRVQIETV ENMPHDTRRH LLTLVDFFAR YELKVKEQIE
IVKAPFRKEI SNVMLLFHYK KADWWRAQLD ILSLKRQLVA VVKKYKDCLC QSVGSLITTP
LCSKIYCMEI EASENASNSV DEILPQNWFS LDEFQDAGIQ SDQLDDCRSF CNNINSISDY
YSKHWKTICD SLCTNVTKLN DFLLQLKTPF QEELADKTNC PSSTAISEEK LFKFALQQRQ
QTAWKLVKIL KKQGFLTRLH TEPAVIVKTL KEVPSALPSK NFDSPAIYSK TQTLIDQFWI
CFSHTLNCFA MQETSTNDQQ LSISMLRALK GLTSGMVDKL ICRVGTLAGR MIVLQRWQRY
KRMLELIREG RVCGLVDDDD NGGATLGKVK KLLQETATLV PFLENLCDVS SSTVRLWSAC
AEWEKARLDA PELLRFQELN VSKPTAPEIA CADRSFQSAA RLEQLNVSIM ESIQFMKKVK
KSCPPVCGIP ILACEDFNKL NDLLLHLFGT VSDEIGEILQ KARCQFDGTV SFHGRHLDRA
WQALQRRREI FDSISSSTSG DLEKVSCTEF VDVDSLIKEL LTVKFQFQTG EKSSADAGLL
HKDVADLDRL CSRYSSWLTK AGKVICCAFF GDEQLKRQAR SCALIYTKFV DLISSLYENC
LENTLIMCDM YVIFCQLCAV LYEKGFAVPP SNAEPQEGEV KNQQFEDAGM GIGEGARDVS
EQIEFQHQVE GLAGEEDQAS DTQASMEDVE CPIEMEDNFD GNLENLPNSN KNDEDDDTDE
DENDLDQDLK IDMEMDNVSD EEAERQFDPD PLEKDNKTRP ENFDSTMEGA NKVDDNQLVA
KEEQEAEFEG GVAFIVLILY LKNLNLFIYD GILDSGDQNM DNKCEEDDER IYEVPELNAN
ASDNDERGEK EQGKEEDDEA TRQDSTDADD DDDEQLMSDN DLTEQDDQRE EEDGDGVEEN
VEENSVVMEE KLFTQGGAQQ SQFGSGAQVG ADDEQQLNAE TDAGCMETDL QSRTADMQQR
NSAVSSLPDR SEMGSSVPNR SGRHNLPTAD VQTFAEPFLK RRKIEPAECE QRTVGDLSKN
TLTNPAVALE NSSSAVERSE STDADEGHEQ ANAFAHAADL DDDAMQIVDS ADLNTALNKA
ELPDNEEMDF ESADEGDKEE EEEADVVHDR IMTDGNAIIP KISAEIVHDD KIDDPIDQEE
QNLDAEHNPT DEQQNNAASS FHTDRTFFHC QTDDNISDVK DAILPVDVDS FANTDSWNGS
VDQWKALVEQ SRVQAVELCE SLRCLLEPTV ASRLQGDYRT GKRLNLRKII PYIASGFRKD
KIWLRRTRKT KRDYQVVLAI DNSQSMQLNN VKTMALQSLA MLNEAFHVLE IGHVGVCKFG
TEPILLQPLT KTFDVHYGAK IIEQLNCNEQ QTNIFKICII YMHIYIYIFG LLFKLLQCAA
SLFTCQRASS DRTDSGMPTK LMIILSDGRN VYNVGEQALK DAVRSVFSAG IFVIYIIVDN
SSNANSVSNH RMVIVKPSGE VEFVSYIDRF CFPFYITLNR CDDLPKVISE ALKQWIEFVA
EC
//
