ID A0A0V0SHC1_9BILA Unreviewed; 3604 AA.
AC A0A0V0SHC1;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=Histone-lysine N-methyltransferase 2C {ECO:0000313|EMBL:KRX25946.1};
GN Name=KMT2C {ECO:0000313|EMBL:KRX25946.1};
GN ORFNames=T07_1707 {ECO:0000313|EMBL:KRX25946.1};
OS Trichinella nelsoni.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6336 {ECO:0000313|EMBL:KRX25946.1, ECO:0000313|Proteomes:UP000054630};
RN [1] {ECO:0000313|EMBL:KRX25946.1, ECO:0000313|Proteomes:UP000054630}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS37 {ECO:0000313|EMBL:KRX25946.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX25946.1}.
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DR EMBL; JYDL01000009; KRX25946.1; -; Genomic_DNA.
DR Proteomes; UP000054630; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd15512; PHD4_KMT2C_like; 1.
DR CDD; cd15513; PHD5_KMT2C_like; 1.
DR CDD; cd19171; SET_KMT2C_2D; 1.
DR Gene3D; 3.30.160.360; -; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 4.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR034732; EPHD.
DR InterPro; IPR003889; FYrich_C.
DR InterPro; IPR003888; FYrich_N.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR003616; Post-SET_dom.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45888; HL01030P-RELATED; 1.
DR PANTHER; PTHR45888:SF6; HL01030P-RELATED; 1.
DR Pfam; PF05965; FYRC; 1.
DR Pfam; PF05964; FYRN; 1.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF00628; PHD; 1.
DR Pfam; PF00856; SET; 1.
DR Pfam; PF13832; zf-HC5HC2H_2; 1.
DR SMART; SM00542; FYRC; 1.
DR SMART; SM00541; FYRN; 1.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00249; PHD; 4.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 3.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS51805; EPHD; 1.
DR PROSITE; PS51543; FYRC; 1.
DR PROSITE; PS51542; FYRN; 1.
DR PROSITE; PS50868; POST_SET; 1.
DR PROSITE; PS50280; SET; 1.
DR PROSITE; PS50016; ZF_PHD_2; 3.
PE 4: Predicted;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Methyltransferase {ECO:0000313|EMBL:KRX25946.1};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000054630};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:KRX25946.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT TRANSMEM 3113..3132
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3190..3214
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 197..250
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 247..297
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 324..379
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 2187..2295
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT DOMAIN 2562..2678
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 2686..2702
FT /note="Post-SET"
FT /evidence="ECO:0000259|PROSITE:PS50868"
FT DOMAIN 2945..2995
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT REGION 120..144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 946..1017
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1204..1245
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1327..1348
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1394..1445
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1471..1505
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1626..1665
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1736..1755
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2985..3012
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 124..139
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 946..1014
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1204..1244
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1629..1657
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3604 AA; 404772 MW; 1A6B27E8BFBB649C CRC64;
MTKVHFKLSI RWISLLEVNE KSGKTPSISN SYRMQFNILQ NYFYFTEAMK YWGSAFKEAY
LRFKFKITHL IVWYLGKIYR SEMMDLSYSH TSVEPISLPP QNMITGHALP ENVSRKKIST
FKRNSASKGK GGSTSSRSIV DKRRSQKCAK NRRNAVQTIT EILNHHLAPN VAKHKEDDEY
IHSVVVTSVK DSYVFCRDMC VVCGSFGRGQ EGHMVACTQC GQCYHTYCAN VTLNSVIVHR
GWRCLDCTVC EGCGTGDDEQ HLLLCDECDV SYHMYCLDPP LDSIPQGAWR CKWCSTCQFC
GATPPNGMLD SIKNLRACFK CASLYSCCFC HLQYKEEDMI ILCDICHRWS HANCNGLCAE
DILKKGLDAG FICVYCRPGD ACSSAAMHFV IEGVLLTKSG LSTVQWRPKP AASPVCSAVY
NSTPSFESLQ NATADGFSEL STSQLMIQDG VVSASPDMEK LDFEFSSNSD MTIYESQNGL
DSFGSVDRQK RVRNRKLFKV GIGGFHTRLA RSRYDKLQEE CVATASPEMM GNSLGGNAQL
DNNAVAAGDS IVEEGHDKPK RRKRNRRKVV LEDYYPSYIQ EAFFGISAEE SSYTNGGNVN
GPAPFPMSPF DLQEQDIAFA IPRSPDTEIN SEVIKNAESS SQAYKLRNAN VLPEVCLNEA
IDMNENEEIF PHELQNHDFT NLLDMLMQAD MDPIVSNTDI SAIDSVEMDT LMDNVFDAEL
KRASELTETQ LLANSAAAAA EMHQPNGRCL KDSTAICGDN APTPFVSLPV EIGTAASQQM
APKNFNEQTD LIGGEVVTVW EGVGILEQSL AVFRKGLFLF RGNMAGNIFP NSNNSSNSNN
VNSDNMIGGG MVESTAVRPR VCESPPVEAK NYLDRWLQDE PLGDRSSIAA VLYANLNAPD
LKTRYPCWPD RAKCIAKIWR SLNQDHRQQY VQMARENRSL MRQECKARRQ QQQQQQQQQQ
QQQQPCLLAS SPAVRRSSSS GGQLMKLIES SSPPSMVNCA ATSDTASNPM SRATPAPMPL
NITVADETSH RADIPMKPHF PVIRDFFPFQ QRLHNQHHPN QQHFPTHLIH HNHQPQEDQQ
RQLKNYTMNF SQREFFQNHD GTAGTVAQHQ HQQQRKFSLP EDGLAFAVQK NDVIKQPVDH
QYGHHVMVNS GESFRLGKAE PLDALGRRAS CPSSAEALVG MAACCNNSLS SALAPAPVLS
PSQAQISTRE MRSPPVSWSQ ANRVDHHHQQ QQQQPQQPQQ QGQFGCAARA KLLPRTPVVG
DGHELMTSMR NQQGQNHSNK QQQDNKLAQV AQSVETTMHE EWLMQTVGSL EHQQKSLESE
LNQLRRTKKN TASKQRQMRK NGVEPPQADQ AALASLTQTI GERQKLLERI RKQLKTHNSL
VQDYQQQDKR VDGALSIAGG GSGQSSSYPA PAQSPVPSPA YQPAVSPMDC GFAADPGHTA
PPRSEQAFMA PTAGQQRHFN FVQPMLVDHH QHLPQQQQQQ QQQQQQQPPP PPHYPQQQQR
HYEQQHPNLH PQSALTAANF GVLPMNGASG LGAGQTVAPE PSPSAVGTEM MKPTMMNITA
PPYYQRMVPV RVPLDSTVAV APGLAPPPPL PDPPLPPEFA AAYVNEGMIH YSMPGRRFAP
HPLGDVAVGA AAPPPPPPSL PVQPPQAQAP PPPPYHHHQQ QQQAYDGIPD DETILSRTKC
LNLCSMSRCY GSEVVATVKD LLDRVSDDEY GEATEAVLHM FSKIYPTDQC YDFDGSRRKG
KGQLSRKRSR RSNKAKSFCG NEDAVDEMGE LTDHQWFYYL QQLPPLTIVE PESRFDTAIT
HFYGVTPLTD CKGLVEGTMA ESSTRGQIEK SFSNVKVEND FLFENRSSNS PDELIYSDGS
GDEENLPCYP YLKPEMSADG RLSPNFRLVA PVPVRAVPGD PPAGALSKTI NEYVQSQQSR
VVTLTLDSAA ASNVSNVLRN LACLLNVDVP ELFDLQIDTP PHTPDRVLSR EYAETQRRFC
CYCATALQQA MVKKNLAELG FTPKNDDSDE VVFCSDACFV QFAVSRKMPI SPGNPSKVLP
NKTVITSGFE NALERSNSSS MSICTANQLR IAESENSRHR LVNSIKLDEI IRSVVGTSKV
YTGTSKESVV HVRDLPRLKD TVEVENENQD ASHYESKIEK KLKGARWQLY NNCQKSLLKV
LACNTPEALW KEMLSIFWLP QSLPQDTRIC ELCSRMGDGE TEVCGRLLNM DAGRWVHVNC
VLWSAEVYET MDGGLVNVEQ AVRRASVTRC VLCDLPGATI PCYKMKCGSN FHLHCAVDSR
CTFMMDKTMF CFEHPPLCRD KILYNLAVFR KVYIERDDEQ LLSKLYQQSE SGEYAMRIGS
LLFHHVGQLL PEQLNRFHTK DCIFPVDYTV SRIYWSTFHP RRRQIYQCHI GEFEGAPLFS
VTAKYPGTAE VRYQSKSINE VWQNNILTPL QGLRNCNDML KLFPSYISGE SFFGLFEPSI
QKMLESLPGI DSLVTYEFKY GRSLWMEPPL VLNPSGSARC EPCFRTYIKR SRKLNAMSAH
SIQSLLAFSG MPSDGYFYSF GNKQSLVAKC YQYRKLKQEW KSNVYLARSK IQGLGLFANR
DVEMNAMVIE YVGEVIRNEV AERREKSYQK RNRGVYMFRL DSDHVIDATV AGGPARYINH
SCDPNCIAER IDFDRESRIV IMSCRPICKG EELTYDYQFD FEDELNKLPC LCRAPNCRNK
EAVYMKLQTG CASCVRFTTF AEGTILALRM VSSQSSERQR NLPSSEPLLF LFDINMKFDI
LNAPQSDVKR LLFSDSFFVL CEKTLTEMAA SFGYYTGGQH VENLAPNNAC MASSPNEEFY
FAVPDEQRQF VSSGPQATTY WDNSCNLNAV NPVEFQWTTD HYYPLTNWNS APTSAAAYTH
GVGNVVDEGA VPARTFIFNG QSCWNLLAED SAIAVVKNNQ IEEADEEELA SADTGTVSKN
RNPCRRRCAH SVIERRYRSS INERIAELKT LVLGPSARAS KSTVLRAAID KLKQLKQLND
SLRAENEQLK ACCTCSPFSL SMHSLDFGQN NFDISVSSTE ELNNNNSNNS SVSTNSKFTL
FLLFACFVIV NPFHMVSQIS TVGVAPLGKL WNAPLLKSVD ISRIRAEIIE NNILRILLLS
VINGLVVALV IVKLRFCRRL ILKDPTCPKV KSRSLTVVGN ERGREDSPPP VPAPVVMRCS
QFKRTFAEQL LQILLTFFHF ILLPVNLLCL LSNVDDEEQK SADMGKFHYS NPTLLQHFTD
DKPHLSRFAD RKRYSSIELA LNSVKLAAKV DNKLEKPILV NVYCMAALQI RLLPWIGNSL
AKLLYNRANQ EYRKVDSDLN VCWLFTPIGK KFFFNLNLND KQFWLLKRAL LLNSKETEEY
LNFVKHSRDE FKKKRLFGVT MSNQETDYFW FVSFILFGFG QDHRASLMDE RNFLKDIQEL
ATSAVQEACC KAAIACHLGT SSENKENIVC EILQLCMDVH QSMMSSSVAD DPLENITLVL
AVDWCLKALI VSSEMNVHLL VNKNCTNADV NGKHMFRLLL KQKRRFISNL QPFLSRETIR
YEAIGCLLDG MNPTFVQKLL MKYAKVDQFD RPWTCTNNSG GIEKWLFSLG PQQWLTSLLL
SEEN
//
