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Database: UniProt
Entry: A0A0V0SMI2_9BILA
LinkDB: A0A0V0SMI2_9BILA
Original site: A0A0V0SMI2_9BILA 
ID   A0A0V0SMI2_9BILA        Unreviewed;      5112 AA.
AC   A0A0V0SMI2;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   10-MAY-2017, entry version 11.
DE   SubName: Full=Ryanodine receptor 44F {ECO:0000313|EMBL:KRX28175.1};
GN   Name=Rya-r44F {ECO:0000313|EMBL:KRX28175.1};
GN   ORFNames=T07_2368 {ECO:0000313|EMBL:KRX28175.1};
OS   Trichinella nelsoni.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichocephalida; Trichinellidae; Trichinella.
OX   NCBI_TaxID=6336 {ECO:0000313|EMBL:KRX28175.1, ECO:0000313|Proteomes:UP000054630};
RN   [1] {ECO:0000313|EMBL:KRX28175.1, ECO:0000313|Proteomes:UP000054630}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISS37 {ECO:0000313|EMBL:KRX28175.1};
RA   Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT   "Evolution of Trichinella species and genotypes.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KRX28175.1}.
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DR   EMBL; JYDL01000001; KRX28175.1; -; Genomic_DNA.
DR   Proteomes; UP000054630; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd00051; EFh; 1.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF13499; EF-hand_7; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00054; EFh; 2.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 2.
DR   PROSITE; PS00018; EF_HAND_1; 2.
DR   PROSITE; PS50222; EF_HAND_2; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Calcium {ECO:0000256|PROSITE-ProRule:PRU00448};
KW   Complete proteome {ECO:0000313|Proteomes:UP000054630};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|EMBL:KRX28175.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054630};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4462   4486       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4661   4680       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4721   4747       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4865   4887       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4910   4932       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4991   5010       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      103    157       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      164    208       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      218    272       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      278    339       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      344    402       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      582    817       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1045   1231       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     4212   4247       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   DOMAIN     4250   4282       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   CA_BIND    4225   4236       {ECO:0000256|PROSITE-ProRule:PRU00448}.
FT   CA_BIND    4260   4271       {ECO:0000256|PROSITE-ProRule:PRU00448}.
SQ   SEQUENCE   5112 AA;  582796 MW;  E5B68843A2BCCBB7 CRC64;
     MTDFQENSTG EQDDISFLRT GDVVCLTCLA PCKESGTGSA ERVSLAAEGF GNRICYLEIV
     SDKNKPPDNA TSMFYIDQAL SVRALQEMMS SESPNISGSS STHRTLLYGH AVQLKHALSG
     MYLTCLSTSS ASDKLAFDVG LCETNVGEFC WWTIHPASKQ RSEGEKVRFG DDVILVSVAT
     ERYLHMSSTN GNTVLAAFHQ TLWSITPNSS GGVRERNMGY VCGNDVLRLN HGNDECLTIP
     ENWSDSPQNN IVIYENGKSC NQARSLWRPE LIHGKWQSSL IGWEQAFRIR HITSGRFLAL
     NEDNQVCLLH KDKASFESTA FIMISSKDVK RSTFEEKEEE GMGVATVKYG ETVIFLQHLQ
     SNLWLSCQTT AVTKKNMGKV EEKKAIAVEE ARMDDCFILF KAQEEESQSA RVIRKCSQIL
     NRFLRGLEGL QMEGKDSLAW NRADLSETVK LMEDLIQYFA QPEESVDFES MQNGLRALRN
     RQDLFQEEGL LNMIIDTIDQ FSAVESMTEL LDVTKEDKCK NWQDISTYLY LLVAAMIKGN
     HSNCTQFASA QRLNWLFSRL SNPQSAEGIL DVLYCILTES PEALNMINED HVKAVISLLE
     KVGHDPKVLN VLSALCEGNG VAVRNSQNVI CSELLCNKKF LLQTKMIDQV SSVMANIFVG
     SYENSAMYPR WYFEAELEYM ESMRTSGQKP HLRIGWASSA GYRAYPGSGK KWGCNGVGDD
     MFSFGFDGQC IYAGIAALKL SKLIGGIEKF VGTHEIRKGD VIGCSLDLAI PEIQFSLNGH
     QIGTSVRNFS SCDCLFYPVM SLSAIVSCRF FFGGSQGKLR FGPKKGYLPI SEAAITPVKL
     ISCISFGDTR KGYFAGPSTV ISDYIVFQPK PIDTKDVSLP KHLEDVHEKL AENIHELWAM
     DKIEKGWIYG ERRSETQKTH PCLTSYERLP TAERSYNLNL AKETLKTIVA LGYRIDIGKA
     SNRVKTFRLG QNFLMSNGYK PAPLDTREYE LNETLETLVD LLAKNMHNIW AQSKIQRGWT
     YSKNENVNIK TTSHLVAYDF LDPNIKAANR DKAGQIIRSL LVYNYCIEPP TAEQDEGAVK
     QSQVMNLQKR TYRFEKRYAV KSGKWYFEFE IRTSGFMNVG WMDVSASPDG DFGLHKSSYA
     YDGYLGRKWH GESESYGKKW NVGDVVGCFL DLTDRTICRL YVGFSLNGEL LLDSSGTEVA
     FDNVSAEDGF VPAFSLAPGQ IGRLNCGQNV NTLKYYTTCG LQEGYEPFCI RMSRQAPMWI
     AKYEAEFDEI NEQEKRFKVT RIPQSGDNPP CLKLQCKSAG MLERCSLALF RLNLPVFCKE
     ANDNRVCNQY FTETLSERNA GKRNCESDRI AESSRRGKMK GIRSSRNQDE NISFHDQHNY
     ADQYETSNHA VMKSNYLVQK TFSLDEDSSE VTENRFRKAP RLRSSASEAN LKEKESIDSQ
     DKISASYAVS NTKRNLRPFK VLQSFGQRMR DVSVGRSRKQ NARKLQEACA LKSKIRSDEN
     DKFPSGHLNS RKLDDRVADV DSTESLDMPK SGPGRRPTVI RLESDSKVKK RSNYFSSGHD
     LLVEASKLSA PSGNQHVSIG ASVSFYSTPD DYYFGVRVFP GQDLANIWIG WLTPQFSFTG
     SQIAADSQRI CFLESTHGTL DNIQEFRSCY IVNGMELLTA AGGSSNVSKM AGILAGCLIN
     TATGELKFHV NGKQTEMSYR VEPGTILYPA VFVLPTSREV LQFELGHIEK TLPIASAQLN
     ERSNAVQLMC PPRLKMEICK TRTWLRVPDQ CARVTSLKLS DTRGWSVLCD DLVRTMMLYV
     PERDSSIDIL ELAEHESLCT FHQQTLRLYC SLCAQGNFKI AHILCQHVDE DQLMYAIQSK
     YLSGSLRRCF YDVLIAIHLK CHYDARLAES HEYIIPLNAK LKDRNYFNYE TKSVYPHALN
     SDITLKSSIN VMEVKKKIST EDEKFLMSPT FDFHTLKQYV VDALEEATLE ALMNSRDLIG
     GTNTTHFLPI LKLFDTLLLV GVLSDKDIHR FFRLLNPKSF QETLDSPQNV KGLVDLDLDE
     MVQLELCHIM NHLCDLQLQG RVESLINFAE TFDQLRRYLE IKQTDMPSAE AARKTKEFRC
     PPKEQMLKLL DFKADRDEQT DEEGELEVSA MSEFLQRVLR EFHCNMVKFI GNSDKNDDNY
     STNVEQKQLE SENMNWVEKL AWMVVPVPPA LLSEDERIKF DGEEAFRNII LSTLIKWTGN
     KAIDDPNLIR EIFGLLLRQY TRISEMKSAL KTAYCIHERS IEDVQSFLDN LCQIRRLLCV
     QFEATEEEVL KNSLWDMMNN KVFFQHPDLM RLLKVHENVM TIMVNVLSRA QKSELDDRRN
     RSTQDDVKKA FQNSISDLVV ACCKFLCFIC RSSTKNQAAM FEHLPFLLDN ATMLLAKPSL
     RGSVPLDVAY YSFMENSELA LALKEDDLEK VAFYLSRCGL QANAEMVFKG YPDIGWDPVE
     GERYVDFLRF CVWVNGECVE ENANLVIRLL IRRPECLGPA LKGQGEGLFR AFKDAISLSS
     EINNLHKGRD LRSRFNFDLS HYPNPEIEEE DYIDLGAAIL GFYSSLADLL GKCAPDHLTV
     KSGKGESVRL RSILRSLTSV EDLEAILALR FLLPNVFAAK EESSRSSSIG LLPCHKQSIL
     LFLERVYGLI DKEMVFRLLE QSFILDFRAA TILDHPAYAE SDLALALNRY LCGSVLPLLT
     SHAHCFADAE HYYSLLEATL HTVYRMSKIK SLTKSQRSAI TEFLLAFTKE IHPGMMKKLL
     QKVVVDISSL NEFATVPLQI MTQHYECFSK HYGISMHEDT ASEEQKRLSM LLFTTIFDSL
     GKRAFDSDLF ASALPCLTAI GSALSPDYAM QSYAEEEIQN MNVPSGHMEV WRPHPVDASN
     VQLSVNLQNL VQRFAQHFHD SWASRKLEKG WRNDDIYSRT NCTHPRLKPF GMLKEFEQNF
     YKERCSECLK ALLAWGYSIE QETQVSSVQP KSMNPTSNVR SASVFCPQPI DLSNMTLSEE
     MCELAERIAE NSHLIWVSKT IEDLNDANTG IMVLLVPWDI LADSEKRKHR FRAQEVLKFL
     QYQGFRLKSP LHRAREEYQQ TVVDSNTHRP VEKRFACNLL EKLLAYLENA AQKMEVIKPS
     KQFSRYRNYT LPSEDVKFFG KVTDGIFLAI NLIFCLLKVL LPLLESYFRS HRNYFTTASS
     ASLSGVASIK EKEMVAGLFH RLMSVFRSKH NAFGCHVKST VRCLQVLLQA IDFRSLVKIN
     SDTLRTCAQI FLSNMVSDLM NITKEIKNNG RYAEIKGKTL PCTSSLLFLY EAMLPLLTTL
     FCHLSKHGHG QDFLVNDIQV GCYKIADCLY MLASPITISR KSVKEEMEKH RSSIGQCLSA
     FACCFPVAFL EGDFNLNSRG STVDRQHLLS ESKDTSSSLL LNIPSLDNLL SNIEQLSNTN
     GKYQDAPAIF DVDIPMLCSY MSFWWQHGPT NNTQEKNLSA VSSDHINRLF SACSRLICDH
     IGIAHADWIC HLAPFITPMI NYVTIEPVRD YLLPMAEKVR MQADLAFKEE EKHRMHPDVF
     DESTVIELHS ILIRDVYALY PILIKFTDLH RARWLKNPCW ETNALFEHVA FVFKLWSTSQ
     HMKREELNFI TQFESDFMTG TSRKTGKAAV AFRKKKRREG KRREKDSGSI VVACLKRLLP
     VGLSVFGGRE LDLLQKVKEK YMKKENDEKI KEYISSSLAV PDQEDVFDKS HWQRKLYQQI
     GKAQMLGIDS MSQEMVVDKI IFMGVTLCNL HNVEHPQTFQ ADAWRKIVSS QRKRAVVACF
     RMVALYSIPK HRCVNLFLSA YIEKWLKSEK VDEDLLISEV TVASEGRMQR LREDVEEVDE
     QCPPDPLSQL VQCFQRAATS ERKQLVPIVD DNLYIKYVRV MASSIHINDD EQNNAEDDAI
     SMEAQELEKQ QLLHEQSRLA DRGVAVMVLM YLSACNGEPN VMVEKTLALG IHILNGGNSD
     VQNIMLNYLQ EKKDVRFFSS ISGLMNRCSV LNLEIFERQL KAEGLGMGAE LSVGKHQNLN
     DSEFICSLFR FIQLTCEGHN SEFQNYLRNQ PGNTTSINLI ICTVDYLLRL QESIMDFYWH
     FSSKEVVDEA GKAHFLKALS VCSQVFNTLT ESIQGPCVGN QMALANSRLW DAINGFFFLF
     AHMMDKLSKN HTQLELLREF LSLQKDMIVL MLSMLEGNIL NGSIGKQMVD TLAESQQNVQ
     LILKFFDMFL KLKDLTTSQA FQEFDTNKDG WISPKEFLRA MEAQKMYSTE EINYLMMCTD
     VNNDGKIDYM EFTERFHNPA KDIGFNLAIL LTNLKEHITG DSRLDQILQT ASSMCEYFDP
     YLGRIEIMGS NKRVEKVYFE IKEEWLEQFN KPQIKQSKKD FLFNVLQDDG GEQGKLEAFV
     NFCEDTIFEM SHAAEISSED RDSRIERAKK QREIFTGMAD KTDTIAAFDI ILKIMKKMGT
     SIVSFCRYLR PSELRQLKHS AALHFSSMTY GQLILIFLKI VLFIFVTMFR GAFYLMNTFF
     RFILLMMYGV WEEEKASSKL TVENAVHHTL PKDFNIVPQL YEPEKPEVYE AFGIQLTQGI
     GEGLSMKNPN SQPQLEKSFS MHIGNSSPFS FASAESASVQ NERQLMIYNN QIPETYTPAA
     VSVCNDDSNI VVKEIYEPKI AETTSSAKGS AFNFLARNFY LLKYITLALA FCINAILLFY
     RVADNPSNDE KVVLEADNSK LQNEEHMENV IEEELAIHDN YYYLAHMLIF LSVAHCAASL
     ALLIAYYQLK VPLIIFKREK LVARKLEFEG MWITEMPSED AVSGKWDSMI ISSPSFPEKY
     WDKFVKKKVK DKYKDQFDEE ELNRLLGLDK TVVDGSNSSS SSGVDWCYQI WKLGVIFTDG
     SFQYLLMYLF FSAVGIWNPF FYAGHLIDVV ISFPMLQTIL KSVTHNGKQL ILTVMMVLVV
     VYLYTVLAFN FFRKFYVQED DGEETDSKCN NMISCFVFNV YAGIRAGGGI GDELQSPYGD
     EREAWRILFD MTFHFFIIII LLAIMQGLII DAFGDLRDQQ ESAQDKLESN CFICDIGKDF
     FERLPHGFDH HTTKEHNLAY YLFFLMHLIN KDDTEYTGQE TYVWELYEKR CWDFFPVGEC
     FLKQYEEQLM AS
//
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