ID A0A0V0SN04_9BILA Unreviewed; 5226 AA.
AC A0A0V0SN04;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Alpha-galactosidase {ECO:0000256|RuleBase:RU361168};
DE EC=3.2.1.- {ECO:0000256|RuleBase:RU361168};
DE Flags: Fragment;
GN Name=NAGA {ECO:0000313|EMBL:KRX27974.1};
GN ORFNames=T07_3172 {ECO:0000313|EMBL:KRX27974.1};
OS Trichinella nelsoni.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6336 {ECO:0000313|EMBL:KRX27974.1, ECO:0000313|Proteomes:UP000054630};
RN [1] {ECO:0000313|EMBL:KRX27974.1, ECO:0000313|Proteomes:UP000054630}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS37 {ECO:0000313|EMBL:KRX27974.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Consists of at least two heavy chains and a number of
CC intermediate and light chains. {ECO:0000256|ARBA:ARBA00011655}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|RuleBase:RU361168}.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 27 family.
CC {ECO:0000256|ARBA:ARBA00009743, ECO:0000256|RuleBase:RU361168}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX27974.1}.
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DR EMBL; JYDL01000001; KRX27974.1; -; Genomic_DNA.
DR Proteomes; UP000054630; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd00009; AAA; 1.
DR CDD; cd14792; GH27; 1.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 3.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 1.20.920.60; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR002241; Glyco_hydro_27.
DR InterPro; IPR000111; Glyco_hydro_27/36_CS.
DR InterPro; IPR013780; Glyco_hydro_b.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR002347; SDR_fam.
DR PANTHER; PTHR10676:SF314; CYTOPLASMIC DYNEIN 1 HEAVY CHAIN 1; 1.
DR PANTHER; PTHR10676; DYNEIN HEAVY CHAIN FAMILY PROTEIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF00106; adh_short; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF16499; Melibiase_2; 1.
DR Pfam; PF12777; MT; 2.
DR PRINTS; PR00740; GLHYDRLASE27.
DR SMART; SM00382; AAA; 3.
DR SMART; SM00822; PKS_KR; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF51011; Glycosyl hydrolase domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR PROSITE; PS00512; ALPHA_GALACTOSIDASE; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Disulfide bond {ECO:0000256|RuleBase:RU361168};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU361168};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361168};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000054630}.
FT DOMAIN 1880..2018
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2569..2719
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2911..3077
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 1019..1075
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1266..1296
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3190..3249
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3448..3503
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 5226
FT /evidence="ECO:0000313|EMBL:KRX27974.1"
SQ SEQUENCE 5226 AA; 598091 MW; F57A1A0080ACC95A CRC64;
MVDNINEAIV DVSSPAVEIA QVELAEARVF SSFVRRIILL LLEDASGEPC GDAYASALDE
CLNRTDTVEV FRRFIADAQA PALLIERSCE RDSEETADAT EITEVVNYTV STEVHFSSPK
TNGLILIKRG AVLEADKPLI QQLLLFILAD ASPYETLHSY FSTTICPYFK SFVKESGGGD
NYRDTDKAAL SVEKKLIELE MGLLHLQQNI DIPDITLLIH PVVQSVIKQA AEENRRAKVS
DFGKLVDDST FLNQLQNGVT RWVREMQKVI KLDRDPSSGS ALQEITFWRN LERAVFNLLE
KRESPEVILT LEVLKHGKRF HATVSFDTDT GLKQALDTVT NYNVLMKDFP INDLLSAVEM
DRIRAAVASI FIHLRKIRTS RYPIQRCLRL IEAISRDLQI QMLKVLGMRR ILQISFDEFD
KVMTQAFEVF TCWDDEYEKL QALLRDLLKK KREEQLKLIW RIVPAHKKLQ FRLEEIRRFR
RHHEQLRAVI VRVFRLTSTL HGNENEHTFD ESPRMYDAAD TSVVEEVNVA YDFVKDIDCL
DLSKEGSDSW SRIATRLRDQ LGSAKNANEM FRIFSQFNAL FVRPHIRGAI REYQTQLIER
VKDDIEALHE RFKKQYSHSK ACSTSSIYDI PPVSGFVIWA KQIERQLALY LRRVEDVLGK
GWEKHIEGQA LKTDGDIFRA KLNTQPVFDE WVTKVQTRNL GLSGRVFVVE SVRRRNDSKA
SLRLRVNFLP DFITLAKEVR NFKNLSFRVP LAIVNKAHQV NQLYPFAMSM IESVRTYELM
TERLNEKENV AILLAGLVKE IHAQITEGAG LVWESYKLDS YVQKFSEMIA HFQERVEELL
HLEEQIKIQL NLLDTCQYAA PAFQQILSNI QKSVDALSLY QYSNVDIWIK RLDEEIEQKL
AIRLEEGIKS WIRALKGEID EESSSSEDLS AQSKFKVGGD PVIHSFVHEI RITQQVMYLS
PCIEEIQVNL LQQLFSWEAI VTSQARISSS CYHVEIERSS ALTKYRSLLA KLPHGIKYIE
KAYAAIENLK LEVKNYVNEW LRYQALWDLQ ADTLYDRLNT DLSKWMKTLQ ELKEARSTFD
TSETRKQFGV IVVDFARVQS KVSLKYDSWH KEILQRFGTI LGNEMQSLYT VVNKARTHLE
QQSVDISSTS EAVSFITYVQ NLKRNVLDWN DKVECFREGQ RILERQRFQF PSNWLYSENF
DGEWSAFSDI LSRKSTAIQS QVNTLQAKIR QEATAVETRS ADVVTDWNSN KPIKGDQLPD
VALQTLVVYE GKLSRLKEER DNISRAREAL ELQETSHTSV HGERLKAAIE ELNDLKQVWQ
ALNPLYNELA EIKERLWLSV QPRKLRQNVD SLLNQMKEMP ANYRNYDAYD HLKRVLQGYA
KINFLIVELK SDALKSRHWK QLMSLLHVHW NLNELTIGQI WACDLQRYES SIKEIILVAQ
GELALEEFLK QLREFWQTYE LELINYQNKT KLIRGWDDLF NKLKEHINSL NAMKLSPYYK
EFEEDCLVWE EKLNRITALF DVWIDVQRRW VYLEGIFSGS ADIKTLLPTE TSKFQSISSE
FLGIMKKVSM SARVTEILNV PGIQRLLERL ADMLNKIQKA LGEYLERERS EFPRFYFVGD
EDLLEIIGNS KNIPRLQKHF KKMFAGVACI LFNEDYTVIH GVASREGEEV NFLRSISIKE
TPRVNEWLGL VEKEIQNTLA QLLVTCLQEF QKFKVHPIDA DSYYNWLDKF PLQVITLTAQ
IAWSEDVELV LGKNANLEPI LKFVENTLNL LADSVLHEHP PLRRKKIEHL ITEYVHKRGI
MRYLKDCDVN SNQSFYWLKQ MRFYLNADEV DPQKKLTIRM ANAQFHYGFE YLGIQEKLVQ
TPLTDRCFLT MTQALESRLG GSPFGPAGTG KTESVKALGN QLGRFVLVFN CDENFDFQAV
GRIFIGLCQV GAWGCFDEFN RLEERMLSAV SQQIQAIQET LRLTQTKNDA SVELLGKRVW
VSSQMAIFIT MNPGYAGRSN LPDNLKQLFR SLAMTQPDKG LIAEVMLFSQ GFRLAEKLAS
KIVPFFTLCS EQLSNQTHYD FGLRALKYVL VKAGNVKRDH IQQLKEQFQQ VDRSFSEGAI
GEQLPEQEIL IQSVCETLVP KLVAEDIPLM FSLLSDVFPG IPHTKAEMKR LREEIRKVCR
ERYLCYSEVE GELGYTWAEK VIQLYQIVQL NHGLMMVGSS GSGKTKAWQV LLAALGRVDG
VDGAVHVIDP KAITKDALYG TLDPNTREWT DVFLIVFPNL WRRIIDNVRG ESTKRQWIIF
DGDVDPEWVE NLNSVLDDNK LLTLPNGERL ALPQNVRIMF EVENLKYATL ATVSRCGMVW
FSADCVTEEM CFENYLQKLR NVSLDAHEDS GVPVSSLPVT QAQTNLTDQI SPSLQVQRDI
ANILAPYLSC GGLVARCLEF AENQVEHIME FSSCRALSSF FSMISQCIMK ILLYNQQHSD
FPMAFDQMER YITRSLLLSI VWSFVGDARA KYRDDMCEMI RSLTAIALPA QENVSLIEFE
VSIDGEWSSL HNRVPQVEVE SHKVGAPDVV IPTIDTVLHE QLLYTWLADH KPLVLCGPPG
SGKTMTLFSS LRSLPDMEVV GLNFSSATSP ELLLKTFDHY CEYKRTPNGI VLSPVQLGKW
IVLFCDEINL PNYDKYGTQR VISFLRQVVE HGGFYRSSDQ AWVTVERIQF VGACNPPTDP
GRKPLSQRFL RHIPVVYVDY PGELSLKQIY GTFNRAMLRM IPSLRSFAEP LTAAMVEFYL
LSQDKFTPEL QPHYVYSPRE LTRWVRGICE AIRPLETLNV ENLVKLWAHE ALRLFQDRLA
EEDERRWTDE QIDLIAAKHF PNVDVSVVLR RPLLYSCWLT KDYLPVEREE LRNFLQARLR
VFYEEELDVR LVFFDEVLDH VLRIDRIFRQ PQGHLLLIGV SGSGRATLSR FVAWMNGLSV
FQVKIHNKYS AENFDDDLRL VLRRVGCKGE KLCFIMDESN LLDSSFLERI NTLLANGEVP
GLFEGDEYTT LMSQIKEASQ HEGLILDSSE ELYRWFTQQV MRNLHVVFTM NPSSEGLKDR
VSTSPALFNR CVVNWFGDWS KSALFQVGRE LTSNLDMDNT AYKPPDYFPY ACDLVSRPPT
YREAVVNAYV YVHETLHQVV LQLTKRDHRT VFITPRHFLD FINHYVKLFH EKRKDLVDQQ
RHLNIGLSKI VETEQQVTEL QKSLSLKSKE LEEKNALANE KLKQMLSNRQ EAENQKHMSE
QIQSNLQQQL AEVAAKKSDV MKQLAQVEPA VIDAQNAVKS IKKQHLVEVR SMANPPGLVK
LALESICLLL GENCTDWKLM RAVIVKDDFI SRIVNFDTDS VTNIRRQHLG EIRYLSSPPA
TVKLALEAVI FLFTGSSTLD WKSIRGYLLR DDFVSQILNF DTERITEDIR QKMKTKYLDN
PEYNYEKVNR ASQACGPMVK WATAQINYAE MLHKVEPLRN ELKKLENDAE VNKRKVEDVN
AVINQLEKSI ASYKDEYALL ISEGQSIKAD LISVQTKVER SIQLLQNLGS ERQRWEQSSD
TFKTQMETIV GDVLLSAAFI SYAGYFDQQI RLSLFMNWSR HLDEAGIQFR PDISLVEYLA
NPDERLRWQQ HALPVDELCV ENAIMLKRFT RYPLIIDPSG QAIEFLMQEY GERKIIRTSF
MDDAFRKNLE SALRFGNSLL VQDVECYDPI LNPVLNYEVK RAGGRVLITV GDQDIDLSPS
FQIFLSTRDP TIQLTPDICS RVTVINFTVT RSSLQSQCLN HILKAERPDI DSKRSDLMKL
QGEFALRLRH LETSLLQALN DVKGRILDDD SIISTLETLK KEAAEVSRKA SETETVMMEI
EKTSQLYTPF SSYCASLYFT LDHLNQTVYR RVSLGLLHHD RLGFALLLSR IYLKGMSESG
QLKLSKEQKE KLAQLVTLPA FASLAERLAQ TEGVLEWIES SNPEINCPIW WDESKTRTPV
SQALYRLLLI QAVRPDRLLS AAHMFIDVAF GENFMSIGEN ILNLKTIVET EISCNMPLLL
CSVPGYDASG RVDDLSSELD RGLTSIAMGS AEGFDAAEKA VNSSAKTGRI IVYEPPPGIK
ANLLRTFGTI PPGKMTKPPA ERPRLFFLLA WLHALVQERL QYVPLGWTKK YEFSEADLRA
AWECVDTWVD AAAHILLDCF IEKLFSEKSF QPDFALVNNV DSLGNKLTVP DGVRREQYVN
WVESIQALQS PAWLGLPSNA EKVLLTIRGQ TMVKKLLKMN DEDEELAYTP IGEQFEGDNH
KPHWLKQIRE AADHWLNSLP TSLAPLKRSV SNIKDPLYRF FEREVSIASR LLNNVRHDLA
DLIGIVDGNK KPTNHHRDLF AHLNKGLVPE TWIKYTIPSA TTITQWVHDF AERLAQFQLI
VDAVSSGRIK NLKNRLWIGG LLSPEAYLTA TRQHVAQLNE WSLEELKLDV QVANTFDNLE
MDDCSFGVTG LKIMGVSCSE QGRLKISPKI WTDLLAVQLK WVHGIAEKQK LNNTVRLPVY
LYTDRQRVLF SLDFQMDPAI LSVNEFYERG VAINGVVQKS SKFNAVQCMM DVNLVALITG
GASGLGKGCA EQLLKMGSKI VLMDLPTSSG AEVAESLHKT DVVFSPGDVA SESDVSKTLE
FCRQKFGKLD AVVNCAAIGI AFTVYNNTKK QPHPLEPFEN VFRVNVLGTF NVIRQSIGMM
LEKELAEDEE RGVIIITSST AAFDGQQGQA VYAACCGALN SMTLPLARDC SRHRIRVVTI
APGLFNTPLT SFLPEKVRQF FGRLTPYPHR FGEPVEFGHL VKSVIENPMI NGEVIRIDGD
LSGFFYTSWP VNLRALDNGV ALTPPMGWLS WAAFGCQTDC SRYPLSCINE ALYMDMADRL
VEDGYLEAGY NLVNIDDCWS EMKRDSNDQL VADRTRFPSG IKRLARYVRT QVDSNMHDRN
LKLGIYGDFG TETCARYPGS LYFLKLDAQT FASWDVDMLK LDGCNVDVSL MPAVALVEIS
VVTGYSEMSR YLNETGRRII YSCSWPAYEV SLRIKPDYLS VAQSCNMWRN YNDISLSWHS
ILKIIDFYDK NEDDLAAASG PGRWNDPDML IIGYPGLSVD QARAQMAVWC IWSAPLLMSN
DLRFISPYYR EILLNKKAIA VDQDPLGIMG RLIYKSGYVS VYKKPITPVS KTNQHSYAFV
FLNRHPTDRA VVTVEKLELI GLQNPFGYQV EDVFDNFSYG HLMPSAGFQC DVRPTSAECI
VNGIFI
//
