ID A0A0V0SN42_9BILA Unreviewed; 4475 AA.
AC A0A0V0SN42;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Retinal-specific ATP-binding cassette transporter {ECO:0000313|EMBL:KRX28097.1};
GN Name=Abca4 {ECO:0000313|EMBL:KRX28097.1};
GN ORFNames=T07_2342 {ECO:0000313|EMBL:KRX28097.1};
OS Trichinella nelsoni.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6336 {ECO:0000313|EMBL:KRX28097.1, ECO:0000313|Proteomes:UP000054630};
RN [1] {ECO:0000313|EMBL:KRX28097.1, ECO:0000313|Proteomes:UP000054630}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS37 {ECO:0000313|EMBL:KRX28097.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX28097.1}.
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DR EMBL; JYDL01000001; KRX28097.1; -; Genomic_DNA.
DR Proteomes; UP000054630; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd03263; ABC_subfamily_A; 4.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC2_TM.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR026082; ABCA.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR19229:SF185; ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR19229; ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA; 1.
DR Pfam; PF12698; ABC2_membrane_3; 3.
DR Pfam; PF00005; ABC_tran; 4.
DR SMART; SM00382; AAA; 4.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 4.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000313|EMBL:KRX28097.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000054630};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 27..46
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 703..723
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 744..768
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 780..804
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 825..849
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1364..1384
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1669..1691
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1711..1738
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1750..1772
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1778..1799
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2946..2966
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2987..3012
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3024..3042
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3049..3070
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3082..3103
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3124..3148
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3940..3962
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3982..4009
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4021..4046
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4052..4070
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 904..1137
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 1949..2187
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 3203..3436
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 4156..4392
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
SQ SEQUENCE 4475 AA; 511758 MW; A0CA1D245E805661 CRC64;
MTKEPGFCSQ LGTLLQKNII IRIRTKILLV TELLWPLIFF LFLLLIRHST VVIKQPQCTY
EPKALPSAGW FSLFQSYFCT LSNKCVNYSI SDMDLGAPGK NLPINNFIAN IRLAFYNETV
LQETLSFLDD VEDVVNKFSM LDNFQGNFNG VNIADFFTKG DDMMIDLILH DKGLEYDAIE
SLLNSTLTRK FFTDFIEEFD KKFKTLKLQR DDLPLAVISI LNKMLCTEEL FSNYISIRSN
SNISESNPEM EKLLQNFMCK KFPIEIFYRQ NVMNRTALME ITNLILGNMT GLKINTTEAN
SLYITTSQFF EKMKSSELAN NALALWKHFL LHSATNSSLA KNSTFKNLDL ASHMFCGGTL
SGMDNIFKIQ KKLEQLREQM IRTDPRYIDT MRQSGVQLGD DPNIVLPWNL YNQTVICDHF
EHEIIEDKCW LWLQQYNLPH DFTMQLFTLF RGYILVAPSS PIVNRVMSDM SNQLVLIDYF
CQSFLHWYDN METYAEVFKE SKFFKVVGNF ARFFITLHET ANIFQNYTYG EAILKLFYKL
SENNWQNKTV TYMREHLSHL HNMIKCFRQD RFVLMKSENE VERAASCLTK TYQFFLGIVF
DELDNNSTAL PKFTKYKIRM ASYLVDSTSQ IMDSLWNPRP RDRPFIDLKY LYFGFSFVQD
IVDRIIISFH TNKTAPRVGM YAQQFPSNCD LIDLFIKSIE RSFPMFMTLS WMFSVAITLK
NMVEEKQYRL KEFMKIMGLK TSAYWLSCQA NLAAAVGALI YFALFLPYPS VLPYLKNMTF
LQQCSLCLIA QVAFGWGCSF IALYEEGMQG LQWSTLFLPL TADHRLSFGF VLIMLIFDGI
LYLIFTWYIE NVFPGAYGIP KPWLFFFQQK YWSRQKSTLP VACDGINSET VTVIHESSCN
PVGVAVRHLT KVYDNKKACK KALSNLSVNF YDSEITSVLG PNGAGKTTMM SIICGLFPST
SGSVIIYGKD ILSNISEIRQ SLGFCPQHNI LFDNLTVEEH LWFYAKLKGM PTAELNDEIE
NFLLNTKLRY KRKEISKNLS GGMKRKLSIS IAFIAGSKTV VLDEPTTGVD PYSRRSIWDM
LLKFKKGRTI ILSTHYFDEA EILGDRIAII SEGSLKCSGS AMFLKTYYGS GYYLTLIKNS
FGKLHLEKAQ PEELIKFVSN YIPNAKLVRC SAQEVKFMLP SVNLLELKSL VTALDSELKN
IGCSSYGLSE SSLEEIFRHE IKESVKANNT HKKQKLTMPS FKYLRERIRS MLSSISKSTT
TYNAQSKYFK AGNTEKIAVY IDECNDSFDR CQRQQLKSDV KRTSKSEIAC HENDMIKNSS
PALLVRRHFS ENYPITFYES IWRCILLQAA ALFRKRALNF FRDWRTILSV ILLPILLITL
ALYLMSLRFS SSYFEKEYQP LILDSDLYGS SNYLFFADSK QQFLYPYITQ MERHGPGNIC
MNRFSLENSV SQCSPDISES DISWNISNLS YENSSKCFCG KDNTYICSEN AYSFQPPVVK
SPFSLIVNMS TLNITEWLTM TEKTYRKKRY GGFSTGLPSV ITVENSYTDL NETVQLLKER
ILKFFQSTNI NMTILQNSGI HIPTFDTDVF IKLMEDTIPQ YNVKVWFNNQ GWAAFPAYFS
AFSNAYLRGN LPSDSDSDEY GIAVINHPIK GYQKSSLTQE KKNSVAAELA MCVAILLAFC
SVTAGFCLPV VEDQNSDSKH LQFISGMRPW VYWFVNFAFD MSVYIFTVTL TVIILIAFNE
EPYVATSYAI LFMFTIFIAF GLGMLPIVYL LSQLFKSPSL AFVTVLIIGF FIGSITNVLT
TAFEILGVED ENLHNLSMHM KNAFVIFPQY NLARALSDIK ITYHFYSSAN RILDRHYFAD
LISWQVSGKA LFITVVEGFV SIMVLMITEH CCYLFRNQQV YLHLLICIEC KEELQFSESN
KVSSSEDDDE NVTAEQRHAL KGACADNALK VVNLSKVYHT CSSIARESQV VVNDLNFEVL
QGECFGLLGH NGAGKTTTFK MITGKCSISQ GCVYFAKTHA PRSNWKSITD IGYCPQFDAL
DERLTGREIL QFYADIRSMC RKCKDAAVLH YIWRLGLNSH ADRLIRTYSG GLKRRLSTAI
SLIGNPRIIL LDEPTASMDP ESRRLIWDVI LERINLGQSV LLTSNSMEEC EILCNRVGIM
SNGSFKCLDA IQELKEKYGK GYVIALSLKA GNEWQMDSMI QELKDRLKVA VLTEKHVNIV
KFQLASDHTK VSDIISCISA LKEIFCIDGC ALNQTSLDDV FVSLVEQYDE CRDDNVLHLQ
LSFVDGLYSS EFCTVFYLHG VCQTVEDVIV EKLLNSFSSQ SVYEPKALSS AGIFSMFQSY
FCTLPNKCLN YITDDWDLGP VSRKLPINDF ISGFRKSMKK QIAFNKTIEI LDYSKMLIDQ
FWSFSEYQND FESVELMKLY NWTGASGASR LLAITFGIQD VNVSRHFFED LLKSYSKTFA
VDKQEVVETF NEKSFKLLCE ESKAERYFLV NSNKTRTTPR DVHKALCMLS GFADTKSTPN
LDMFLIDHIF NNLTGYEIGF QKFLHLASVL ESYVQAAKQF SFIPAGVDLV EQFLNYNAPT
NLKNDSVMKR LDFLSHIFCG AELTGLDEIL KSQKKLEQLR EDMVRTDPRN IDARREQLFS
RKNENGLPWN LKNSTVCSRY KHNDIGTRED KCWLWLQSYS LPHEFAAQLY TLFRGYIFVS
PRSPVVEKIV EKMKSRLDVV AAFKDILLST FENLEIYRTK FESSKLSKAS KNFARLMKNI
NSIVNLFEND TRQDEKLKLI DFFSNELWRN ASLENFNSSF SQTYNILKCF LCDRFVIVDS
EKDLEQDGSC LTKTFHFFAG IVFPQLNSSS LTLPKYTKYK IRMSHYLVDK TAQISDKIWN
PRPRDRPFLD LRYLYFGFSF MQDYIDSIIL SMHVNKSAAR FGIYAQQFPS NCHRIDTFIK
AIERSMPMFM TLSWMFSVAL ILKNIVHEKQ FRLKEFMKIM GLYNSAHWLA WFLQSFIMLL
ISSLMIVLVV SYGNVLKYTD MGCLLVFFVA YAFAIIPQCF LMSTMFNQAN VAAGLGTLLY
FALFLPYPAM LPYAEYMTNA HLFFSCLIPQ IAFGWGCSIL ASFEEAKIGL KWSTFTHSLS
AMSYLNFFAM ILMLLFDGAL FFVLTWYIEN IYPGAHGIPK PWHFFLMPSY WTGCKTDKEN
KSKVVYSALE SKTQENCNLE VGVSVRNLTK IYGSGNKSKC SLNNLSVDFY ANQITAVLGP
NGAGKTTMMS IMCGLFPPTS GNVLVYNQDI MSNLTEVRRS VGFCPQHNVL FDTLTVEEHL
QFYASLKRLT GTEQKLQIQD LLKQTKLMNK RNAYSKHLSG GMKRKLSIAI AFLGSSKTVI
LDEPTAGVDP YSRRSIWDLL LKCKKDRTII LSTHFFDEAE LLGDRIAIIC AGKLKCCGSP
VFLKQLYKSG CNLNLALSQA DLKNNGNTTA TLVDFVCGFV PDAKLVKCSP QEIQFTFPTV
DLLELKSLIT ELDAKLANLK CSSYGLAEGG IEKIFLQEVA LSKEDQQLPS QHQAFSAQKS
LSGKEEKLAS KLSSDKTPEK KQSPNAVNGL NLEKENFFED RFYHSSLPNS KKSAVTSEQC
KTYFESIWLQ VDGFLKKRML NLVRDWRACV AVQHCYVFKI ILPVFLVALA LYLLSLRFSE
VLFNLDYRPI TVDETVYGRN TYMFYSSVGN EHNSVNKYFQ AIIEDIMKHG MGNRRKKQQL
VHFRLSNVKQ NRTFSEPVTE MKKENLTKCF CDEDNTYFCP KNAYPFKPPE KVTSFGENLV
DMTNLSIANW ILMTEKKYRM KRYGGISLVT LPHEVTEISA TKTGKDWDRL YAHLMEFFES
MGFNNTSLPV DGTPIPEWNM TRLENVLNQV TPKYNIKIWF NNQGWVALPV YTNIFFNAHL
RAALPEAENP DDYGIEVINH PIRNPLEVSM SDGSSVAAEM ALSVSILIAF CSVTAGTCLF
TVEDRSSECK HLQFVSGMRR WLYWITNFIF DLIIFMAAVG LLLVILHFFN ETPYIGSAHA
ILATLAHLTA FGIGIIPIVY CVSQLFKSST LAYVSVMVAG FFIGSITNVL TTSFEILGAE
DEYLNYLSKM LKAYFVIFPQ YNLARGFTDI KIMYHFYVSS GKPMGRKSIC INICIHKDCD
ESLEEVYSDN TSSVALKVTD LTKLYGNWFQ NTNKRFTAVN KLCFEVHRGE CFGLLGHNGA
GKTTTFKMIT RRCSVTSGSV LFPAKKRDSM KYQSEIGYCP QFDALDPRLT ARETLLFYAK
IKGIQKEYQN PIVNYFIHRL KIEAYADRLV GKYSGGIKRR LSTAIALIGN PYIILLDEPT
AGMDAESRRF LWDVILERVH CGHSVLFTSN SMEECEVLCN RVGIMAHGKF KCLDTIHGLK
EKYGHTYVLT IKLEAGSDMN TLKEEIEKML PNSKVLEEHI NLLKFQIPAT KDTVSRIIKC
VAYLKGKFNI EGHSLMQTSL DDVFVALAEE HVHFD
//
