ID A0A0V0TM29_9BILA Unreviewed; 1315 AA.
AC A0A0V0TM29;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Neuropathy target esterase sws {ECO:0000313|EMBL:KRX40072.1};
GN Name=sws {ECO:0000313|EMBL:KRX40072.1};
GN ORFNames=T05_313 {ECO:0000313|EMBL:KRX40072.1};
OS Trichinella murrelli.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=144512 {ECO:0000313|EMBL:KRX40072.1, ECO:0000313|Proteomes:UP000055048};
RN [1] {ECO:0000313|EMBL:KRX40072.1, ECO:0000313|Proteomes:UP000055048}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS417 {ECO:0000313|EMBL:KRX40072.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the NTE family. {ECO:0000256|ARBA:ARBA00006636}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX40072.1}.
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DR EMBL; JYDJ01000211; KRX40072.1; -; Genomic_DNA.
DR EMBL; JYDJ01000211; KRX40074.1; -; Genomic_DNA.
DR STRING; 144512.A0A0V0TM29; -.
DR Proteomes; UP000055048; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004622; F:lysophospholipase activity; IEA:InterPro.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-UniRule.
DR GO; GO:0046470; P:phosphatidylcholine metabolic process; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 3.
DR Gene3D; 3.40.1090.10; Cytosolic phospholipase A2 catalytic domain; 2.
DR Gene3D; 2.60.120.10; Jelly Rolls; 3.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR001423; LysoPLipase_patatin_CS.
DR InterPro; IPR002641; PNPLA_dom.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR14226:SF29; NEUROPATHY TARGET ESTERASE SWS; 1.
DR PANTHER; PTHR14226; NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER; 1.
DR Pfam; PF00027; cNMP_binding; 3.
DR Pfam; PF01734; Patatin; 1.
DR SMART; SM00100; cNMP; 3.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 3.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 2.
DR PROSITE; PS50042; CNMP_BINDING_3; 3.
DR PROSITE; PS51635; PNPLA; 1.
DR PROSITE; PS01237; UPF0028; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000055048};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..31
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 149..216
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 377..478
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 533..597
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 845..1011
FT /note="PNPLA"
FT /evidence="ECO:0000259|PROSITE:PS51635"
SQ SEQUENCE 1315 AA; 150100 MW; 8E6405A0843BF62B CRC64;
MDAFMQFIQL LYENLKIITI GMGCIFITWV INRFMRLNVA TSSATKYPVT FSRKSSFNYR
FRKRDRMLFY GRKLMRKVTS AVINGDKKQK LRKRDRVFRF ASKFLRPQKK DFTARPIRRP
PDAFLEADTS LPVSPKSVQL LNMLKSIRIL GHFEIPFFLD VCKHIETKRF AADQFVFKDG
EIHDCIYIVE SGRLSLFIKD EKFDFEVKSV GRGDSLYCSL SILDMIKNQA RPMKNVFAKA
TEESVVLQLK SSVFNDIFDK YPESWTRTVQ IILLRFQRIT LATLYRYFGF TSELSKTVQL
YRIIFLLLYG LNFQSIRAVS KLSPLQEQSC KDFREIKSEN EGATPEDCTA SENAFPTFGV
STTDDDSDIF QVAIEELAKL FGMKEASFLV DKVKVEKFEP GIMIVRQGSN ELQLFYVVSG
MLELLLESQE DPDVLLPISI VQTGDVIGGL SVLSGEPSFF AVRTRSFCQL AIVERKSLYE
CVTFLNRIIS EYPRVVVNVA STAVESYSDF VKEFDMAVEW EICESGKALY KLQNEQADAL
YVVLSGRLRS VLTREPGTRE VLNEHGRGDV VGLVEIWTLR RRSTSVIAIR DTELCKIYAT
LMNFIKNKHP QVLSNIIRLL GHCIIEQQQQ TVSAVHREPL AHVSNLNTIA VLAVSDEVPL
TGFTVELWNA LNSITPTELF SSYTLQDMLG PTALDKVNEY QIITWLNQQE DGNSIVLYQC
DVELTTFTSL CIRRADCILI VANGEQEPMV GEIEKELENL TVRAQKELIL LWHDSTDRPR
RTAEWLDLHG WVSSHYHVRF RDRVFKQRNP RRMLRYKERI IRRCDNRHTD IARLARALTS
TSIGIVFGGG GARGAAHVGI IKALKDHGIP VDIVAGVSIG AFVGGMYCLD SDVPKLIMCA
KQAFKEAASF WARLFDLTYP VSALFTGKAL NRLLKSVFND VEIEDLWIPY FNVTTDITSS
EMRVHRSGKL WRFTRASMSY IGILPPLCDP LDGHYLVDGC YMNNLPGTLW RYCRASMSLA
GFVPPIFDLT DEHLLLDGGY VNNLPADVMR SLGVRTVIAV DVGALTETEF TNYGDSLSGW
WALWKKYNPW ASPVRVMSMA EIQSRLAYVS CVRQLEEVKK APYCHYVRPP IDKYQTSSEL
CSPIQNVGYW HGKTLLEEWK SSGKLQEVFD GRSANLSKFA QREKFKRGFA FTSAQSFTDL
AAMVSKIHRP FETSLDEISE EEGDDRIPLD LIHTTSSSSY YNNNLKMSGH RVVISRDDVD
QFDKLLEKSG CAKEHYVLQD CYAEHKDWRK CKKEIDALRK CMKVEDRTES ADNAT
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