ID A0A0V0TMS8_9BILA Unreviewed; 288 AA.
AC A0A0V0TMS8;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=Translin {ECO:0000256|ARBA:ARBA00022196};
DE AltName: Full=Component 3 of promoter of RISC {ECO:0000256|ARBA:ARBA00030513};
DE Flags: Fragment;
GN Name=Tsn {ECO:0000313|EMBL:KRX40361.1};
GN ORFNames=T05_9068 {ECO:0000313|EMBL:KRX40361.1};
OS Trichinella murrelli.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=144512 {ECO:0000313|EMBL:KRX40361.1, ECO:0000313|Proteomes:UP000055048};
RN [1] {ECO:0000313|EMBL:KRX40361.1, ECO:0000313|Proteomes:UP000055048}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS417 {ECO:0000313|EMBL:KRX40361.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: DNA-binding protein that specifically recognizes consensus
CC sequences at the breakpoint junctions in chromosomal translocations,
CC mostly involving immunoglobulin (Ig)/T-cell receptor gene segments.
CC Seems to recognize single-stranded DNA ends generated by staggered
CC breaks occurring at recombination hot spots.
CC {ECO:0000256|ARBA:ARBA00025374}.
CC -!- FUNCTION: Exhibits both single-stranded and double-stranded
CC endoribonuclease activity. May act as an activator of RNA-induced
CC silencing complex (RISC) by facilitating endonucleolytic cleavage of
CC the siRNA passenger strand. {ECO:0000256|ARBA:ARBA00025410}.
CC -!- SUBUNIT: Ring-shaped heterooctamer of six TSN and two TSNAX subunits,
CC DNA/RNA binding occurs inside the ring.
CC {ECO:0000256|ARBA:ARBA00011685}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the translin family.
CC {ECO:0000256|ARBA:ARBA00005902}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX40361.1}.
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DR EMBL; JYDJ01000202; KRX40361.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V0TMS8; -.
DR STRING; 144512.A0A0V0TMS8; -.
DR Proteomes; UP000055048; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0003697; F:single-stranded DNA binding; IEA:InterPro.
DR GO; GO:0016070; P:RNA metabolic process; IEA:InterPro.
DR CDD; cd14819; Translin; 1.
DR InterPro; IPR033956; Translin.
DR InterPro; IPR016069; Translin_C.
DR InterPro; IPR002848; Translin_fam.
DR InterPro; IPR016068; Translin_N.
DR InterPro; IPR036081; Translin_sf.
DR PANTHER; PTHR10741:SF2; TRANSLIN; 1.
DR PANTHER; PTHR10741; TRANSLIN AND TRANSLIN ASSOCIATED PROTEIN X; 1.
DR Pfam; PF01997; Translin; 1.
DR SUPFAM; SSF74784; Translin; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000055048};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KRX40361.1"
SQ SEQUENCE 288 AA; 33650 MW; 7F562C601E41EC78 CRC64;
LSNLVFELVL LNRFGISVQL HNGEFHFENH FFLVQICNVG LKAMILLHIA KNEQLLHLEM
DDFSVIEDDF KTYDKEFQVD LKSKEEIDLL VFGLEGEEGK LASILMQIHQ QPTEEKLSGW
FLKLQDELQN VKTFYSSLAK VVSSDRYYRY HELFRHITQK IVCVAAILIF FTQRHLLTRS
EAAEILGVAE REENGFHLDL EDYLHAILLS TSEFCRFAVN FATFGHYERV DDIADILGKI
SAAFRLLNFK SGNLRKHYDT LKYSLNKVEE VKYNLTIRGL RKYSEQEK
//
