ID A0A0V0TUT7_9BILA Unreviewed; 1184 AA.
AC A0A0V0TUT7;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Glycoprotein endo-alpha-1,2-mannosidase {ECO:0000313|EMBL:KRX42783.1};
GN Name=Znrf2 {ECO:0000313|EMBL:KRX42783.1};
GN ORFNames=T05_5583 {ECO:0000313|EMBL:KRX42783.1};
OS Trichinella murrelli.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=144512 {ECO:0000313|EMBL:KRX42783.1, ECO:0000313|Proteomes:UP000055048};
RN [1] {ECO:0000313|EMBL:KRX42783.1, ECO:0000313|Proteomes:UP000055048}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS417 {ECO:0000313|EMBL:KRX42783.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-
CC pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 99 family.
CC {ECO:0000256|ARBA:ARBA00009559}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX42783.1}.
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DR EMBL; JYDJ01000135; KRX42783.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V0TUT7; -.
DR STRING; 144512.A0A0V0TUT7; -.
DR Proteomes; UP000055048; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016798; F:hydrolase activity, acting on glycosyl bonds; IEA:InterPro.
DR GO; GO:0008168; F:methyltransferase activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:InterPro.
DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd11574; GH99; 1.
DR CDD; cd16695; mRING-CH-C4HC2H_ZNRF2; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR026071; Glyco_Hydrolase_99.
DR InterPro; IPR016195; Pol/histidinol_Pase-like.
DR InterPro; IPR002738; RNase_P_p30.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR007848; Small_mtfrase_dom.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR13572; ENDO-ALPHA-1,2-MANNOSIDASE; 1.
DR PANTHER; PTHR13572:SF4; RE57134P; 1.
DR Pfam; PF16317; Glyco_hydro_99; 1.
DR Pfam; PF05175; MTS; 1.
DR Pfam; PF01876; RNase_P_p30; 1.
DR Pfam; PF13639; zf-RING_2; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF89550; PHP domain-like; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}; Reference proteome {ECO:0000313|Proteomes:UP000055048};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; tRNA processing {ECO:0000256|ARBA:ARBA00022694};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT TRANSMEM 242..262
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 297..317
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 167..207
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 1..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 65..93
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..29
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1184 AA; 134383 MW; DF3B70911735458A CRC64;
MGSRQSVANP PRQRGTNSLP ANGSAPGTGY TSAGRGGAAA SGSYGGVNEI GSDIIGRMLS
QSLQSRTNRS YSMPGPSSSM LDHSSDSSDP DSSSMGLFSL DRWLNLSTES DGRGIVDIAH
IPSAHVRYFV CHKMIPSDDV ECHLVMCLTR PRLTYNEDVL TEEKGECVIC LEEMKEGDTI
ARLPCLCIYH KGCIDNWFKV KNTCPEHPVT AFEQSFEEKN NIDQSFVAHK SFTKLVIFRS
EIALLSVAIC ELSSFIAVWW LIFHFNACFD CSFIKTEKAS IQQRANQPAQ PILFSNLTLN
ITVLIYIVIF TLFTMLMRFT MRRICIIVIF WFAMQFNTIT FEKSILPRPV FSRKSNSEPD
YSVHIFYYMW YGNVAFDQFF LHWNHRILPH YNPLIASKYL VGRREAPEDI GSNFYPKLGC
YSSRDPKILA QHMQWIRDAG IGVVVVGWYP PDASDDEGHP WDDAIPSLLD EANRWQLKVC
FLIEPYKGRN GETIRTDIEY ILQSYGRHDA FYKILTNGIS KPVFYVYDSY LVSNSDWQAL
LLTDGKNTIR NTDLDSIILA LLVKRTDTDA ILTTGFDGFF TYFASTDFTD GSKPSNWPDL
VLFATRNGLL TSLSVGPGYV DERIRPWNGE NTRSRCNGSY YEKMWKAAVN CKPTFVSITS
FNEWHEGTQI EPAVPYKNEN YEYLNYLPME EDFYLKLTKR FIDDKSDLHI AKKYRDFVYP
PSEDSYLLLE AVQLDWEKIK TLKPVICLEI GCGSGVIACS VAKSLQSGAV VFTTDISQIA
VELTKVNVEQ NNIDKIFCPI VADLISPLYD RLLNSVDLLL FNPPYIPRLS DFDDTDELSS
TWCGGGPEGT DILRRIFFQI HNLLSDNGLF YLVAIEENNI EKLLQLNSHL VGKGKNKMAS
RLAKIHFVEL NIVRRLDESE KHVVSAVKYA VEELGYTSVA VNVELSATND NGQRNSGLVV
PEPLLVDWAN VVERSKPWRL YTRLTLKVDS VDLLSSLMNN ETVLKYDIIA VCPLSEAIFN
FVFNNVEVDL LTTDMMNRDV WFEDESCYRK AVQCGKFIEI SYSPAILSAE KRIEIFSHGN
ELFRMVGRRG VILTSRAFGA FEMRGPYDVI NIGYLFGMNP NEARDAITVN PRKLLNAVGI
KKRTLSHTLF TRHFSQLQMN EVENILQVPE FKIEIETNSS NEKQ
//
