ID A0A0V0TXM5_9BILA Unreviewed; 3782 AA.
AC A0A0V0TXM5;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Laminin-like protein epi-1 {ECO:0000313|EMBL:KRX43789.1};
GN Name=epi-1 {ECO:0000313|EMBL:KRX43789.1};
GN ORFNames=T05_12924 {ECO:0000313|EMBL:KRX43789.1};
OS Trichinella murrelli.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=144512 {ECO:0000313|EMBL:KRX43789.1, ECO:0000313|Proteomes:UP000055048};
RN [1] {ECO:0000313|EMBL:KRX43789.1, ECO:0000313|Proteomes:UP000055048}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS417 {ECO:0000313|EMBL:KRX43789.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
CC Secreted, extracellular space, extracellular matrix, basement membrane
CC {ECO:0000256|ARBA:ARBA00004302}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00460}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX43789.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JYDJ01000111; KRX43789.1; -; Genomic_DNA.
DR STRING; 144512.A0A0V0TXM5; -.
DR Proteomes; UP000055048; Unassembled WGS sequence.
DR GO; GO:0005604; C:basement membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR CDD; cd02795; CBM6-CBM35-CBM36_like; 1.
DR CDD; cd00055; EGF_Lam; 21.
DR CDD; cd00110; LamG; 5.
DR Gene3D; 2.60.120.200; -; 5.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.10.25.10; Laminin; 21.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR000034; Laminin_IV.
DR InterPro; IPR008211; Laminin_N.
DR InterPro; IPR002049; LE_dom.
DR PANTHER; PTHR10574:SF435; LAMININ SUBUNIT GAMMA-1; 1.
DR PANTHER; PTHR10574; NETRIN/LAMININ-RELATED; 1.
DR Pfam; PF00052; Laminin_B; 1.
DR Pfam; PF00053; Laminin_EGF; 20.
DR Pfam; PF02210; Laminin_G_2; 5.
DR Pfam; PF00055; Laminin_N; 1.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00181; EGF; 11.
DR SMART; SM00180; EGF_Lam; 21.
DR SMART; SM00281; LamB; 1.
DR SMART; SM00282; LamG; 5.
DR SMART; SM00136; LamNT; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 5.
DR SUPFAM; SSF57196; EGF/Laminin; 18.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR PROSITE; PS01248; EGF_LAM_1; 7.
DR PROSITE; PS50027; EGF_LAM_2; 15.
DR PROSITE; PS50025; LAM_G_DOMAIN; 5.
DR PROSITE; PS51115; LAMININ_IVA; 1.
DR PROSITE; PS51117; LAMININ_NTER; 1.
PE 4: Predicted;
KW Basement membrane {ECO:0000256|ARBA:ARBA00022869};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00460}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292,
KW ECO:0000256|PROSITE-ProRule:PRU00460}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000055048};
KW Secreted {ECO:0000256|ARBA:ARBA00022530};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 3745..3767
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 30..313
FT /note="Laminin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51117"
FT DOMAIN 488..534
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 535..580
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 581..626
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 660..705
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 706..750
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 751..805
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 806..858
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1470..1515
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1561..1608
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1609..1659
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1680..1857
FT /note="Laminin IV type A"
FT /evidence="ECO:0000259|PROSITE:PS51115"
FT DOMAIN 1891..1940
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1999..2051
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 2052..2098
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 2099..2145
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 2146..2193
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 2763..2956
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 2968..3139
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 3145..3317
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 3370..3546
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 3552..3754
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT COILED 2612..2639
FT /evidence="ECO:0000256|SAM:Coils"
FT DISULFID 488..500
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 510..519
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 535..547
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 537..554
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 556..565
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 581..593
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 583..600
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 602..611
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 660..672
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 662..679
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 681..690
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 706..718
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 726..735
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 776..785
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 829..838
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1470..1482
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1472..1489
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1491..1500
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1584..1593
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1609..1621
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1611..1628
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1630..1639
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1910..1919
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 2023..2032
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 2035..2049
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 2071..2080
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 2119..2128
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 2146..2158
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 2148..2165
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 2167..2176
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
SQ SEQUENCE 3782 AA; 422519 MW; EB6AF8810D51228D CRC64;
MTVGRCRRKL FVSLLLAVVV VVVNFNLRAN GQVLNPPYFN LAEARKITAT ATCGVQDGQP
IRELYCSLAG ATRYSPYEGF FGYNYEEDLA ELRVVGSSQS SSQDQKKPFV QGGQNCEYCD
ASSVDYSYPA ENMVDGTPRW WQSPPLSRGM QYNQVNITID LEQEFHVAYV SLHMANSPRP
GLWVLERSTD HGETFKPWQY FAETSAQCEE FFGPDSLQPI MDDDSVICST EYSQIVPLEN
GQIFITLLNN RPGRGNFSHS DKLQLFTRAT NVRIRLLRTK TLQGHLMDLN DKKDPTITRR
YFYSIKEIEM GGRCVCNGHA QTCDILDPMR PNRLLCRCEH NTCGDQCDRC CPGFEQKQWQ
PVREGQVFAC EPCNCHGHSD ECEYDEEVDM KKQSLDIHGK YEGGGVCKHC QHNTEGINCD
KCKFGYFRPP GRPLHAMDVC IPCQCDSPFF DGNCAPDTGK CFCKDRFQEP NCDACSFGHY
DFPECKPCEC FINGTSDALC SPDHIGQCHC KENFGGLLCY ECRQGYFGFP ACRKCDCDVI
GSRNQVCNQT SGHCSCLMNY EGVRCDRCRA GYFGYPKCDY CNCHSIGTTE EKCDLHTGRC
LCKPGFTGQT CGQCMIGYYG LPECKREYLL FFFPITEKIE KVVIRFGINF FLFSCSSIAC
NCSSIGSLSE TCHAETGQCQ CRSNFGGLQC DRCSAGHFDY PHCKPCECNR FGSLGTTCDD
NGHCFCKANF VGQKCDRCKQ NFFNYPLCEE CNCDPRGVSL NFSGCDKVPK GDLCICKSHV
TGRRCNECER FHWNLQYHNV HGCEPCGCNP AGTLSSLTDC DHLTGQCYCK SNVFGRDCSR
CKDGFYALNP SNPLGCKPCQ CDSGGSFSNI CDPRTGQCFC KPRVGGRTCS EPIEAHFYPT
LQHLKYEAED AVTVDNQPAR FAVDEHLFPD YSWKGYAVFS PIQDEIHIPV HIPKSSVYRI
LLRYQNPTQQ DITAVISMHP IYTHTNRDRD VEQSVDMRLA KTILPSFQLV PSSAQPHPFV
LNPGQWLLKI KSAHRLLLDY VVFLPEAYFG ATSLHTSFPK PCLQFNESDA AVCEMLIYPK
LSKPSVDLDN FKVDGQPEKL EFYPVQLPVS GDQHLWINSE NRYSIEVKPE KMANYTLVID
YYNFDDDIVP ADVEVSNGLV RTKGSLVFHY CPYSTFCREV VSANGQPLWF ETNDNLVVHI
QTGKKPNLAL VKSVTLIPSE DWDIELLQPQ PQCIKMDGRC VGFAYLSLPS ASRTEVESVY
RNATISGYDL PFMIYDPEIQ VIPLNISAEG IIHFTGSVPK PDKYVFVMHY YSPVHSKMII
ESDIRSVHND TAYLPTSSYG QQSNNALLEL KFCPSVSGCR SVVYGSGDSR SIAFDIRDRF
LLSLFPKSEQ MQQNTYLDYL LVIPITSYSD DVLYPVSADR ARIDMGNCSK YLNQPSATTA
AAVVVADDDE QCKQLIFSLT VDFNVGAISC DCNLEGSTSF VCERYGGQCT CKPNVIGRQC
TQCKPGYFGF PNCKPCACGP NRMCDQHTGY CFCPPLVEGP KCERCQANAY GYDALIGCQE
CACSAPGTQN QATQCDQLTG QCLCVANVGG RRCDRCLAGH YGYPHCYQCA CDLAGSTAEI
CDQNTAACSC KEHVVGSTCA SCSPGTFNLE MRNPKGCTEC FCFGVTDICQ SGNFAIGEIV
HMTGWKVLHA PSAKLVENDD HKLEIFFDQS AVDDQKLVYM VAPWAYLGNR LLSFGGKLFY
TISAWPIAET TSITVSPDLI LKGNNVTLEY WSEEQPATFD SFFSVEVDLL PERWIHENGE
PVTRAQLMTV LQNVTALLVK ASYYSRLQRV VMKMFTMTSA DSNSVVNPER AALNVEICRC
PPPYKGTSCE ECAEGFYRVN TGPFLGSCVP CKCHGHSNSC DPKTGLCLHC EHNTAGDHCE
QCQAGFYGDA TFGSPMDCQL CPCPLPTVAN NFAYSCQVND RGRLLSCNCT EGYAGDRCDK
CAVGWFGEPT RPDGRCQRCF CNNNNQLTKE NSCDSTNGRC FDCEKNTDGF HCELCAPWYY
GDAVQASNCT ECSCNQCGSE WCDADTGQCQ CKTNVVGENC HRCADNAWGF NYCQGCQMCN
CAEATTTAQC DMETGQCVCQ PGVGGLFCER CADGYWNYSS AGCRKCDCES DLAMGTICDP
ATGQCQCMEG ATGVRCDQCL PGHLLVPYHG CLQCDECVVE LVDDFEQFGK ELDKIENSTH
DLSVAQISSK RLDRLNRTLY QMISNLDNLD NLTQLKNGKN ALQFQDANNI IVTIKRSMSD
AEEARRRAAD FGEYGFKVHR DIRTSSSKLK NQIEKLETFA QSLLESNWNG ANGLTKQTEQ
LKIEVENFLS GIKDADMTRQ EKYALVELEN SNRLVEEVDH FGRSVGKLRN ASAVVATSFD
SINRRVGHLL DQLEQSRTRM EQTEMSYLEI GTAPVFETLP NSNISKIEQT LSEAYELINN
AQSIIRGMGD VRMKLENSLF ELNKSNPVLV AKIEKNGQAI EKIQVMKQAV LEHSDTLDSQ
VRDLEMQFAD SRQNVVDALQ ASRAYKQITD ALTNASRAVD WLSTNRYELL TDPERMDSLE
EEVKEQAGLA MQIVRQASEM RSKMKNHMRK VLSDNDATIA NMRAELNATE QQLAELFNET
DQFDQIRGQL SYANVFTSDT NTLVNEEEQL LKSTLVKDHE TVVKQVDEKL ADQLATISNV
KRAKANVEQI RLMVPELLKN VSSLRDAFVK SVSSMNAVEA GVGLLKEKLA RARDLANKVK
LGVRFYPNST LQLYNLDQLG EIQAQTQVQL YFRTHYPDGL LFFLGNELNS AEMNEKSSLP
SDDDDYLALE IADGYLRATV NLGSGPTVVQ TERLVSDGRW HKATVERVGK LLTLRVSTDH
EPDESVEVFS RGTKSILNLH QNDSKLFVGG VPDSVQLPPS VGSFRYSGQI EALTVNGEPR
GLWNFVLDGR NNTYGAPERK ELLEAVSSGG MYFTGNGYIL MQKDAWNARQ ENEIIFYFKT
YSSMGLLFYM GKERDFFAIE MKRGQVRLHY NLGSGAATLV TPRKYNDGQY HRVHVKRDGQ
QAVLSVGMTD TVKGSSPGKM SHLDVTDEYY VGGVFSSVLP ANSPVIRQSF HGCIERMQIN
GYHVNLNRHL QAYFAEPGCP NRPIRSVAFD RPGSSVKFNS LTWNANVELS FKFRTMLANT
WLLLISDDIA ANTLSVAVQN GFVVLKSKSL GSSEHVVKID AQNFADGIWH YVSISKIGSE
IKLDMDDLFT NSVYMEPLGV YAQSDSTLHL GAIPISDAQF QNMSTFVGCI GDVTYNGRML
NFADSERYGE YISFNICPED LFPSAEQIAA LLPDSDQDVS MTFTTIAVPV VDTCALPLKP
IKHAPCGGNC FRFGTESNSR LEFQSLVSPI DARAEFSLEL RANTFNGLVL YASDKKKDYI
ALYLKDGKLV YEYDSGSGSV SLQSKQSILD YQWHYVKLYR DGRDGQLWID DILQAEGKSP
GLTTRIDLQR PFYIGGLPNE EFRSAKKQHP TLLSDVAAVF SGCMRNILLN NVPMGDASNS
VGIYPCDNEF ERGIFFGEQH GYFVLDNDFM IESKLSFSFE IKPRTKNAVL FVIASGDGSE
FITLQMVDGV VMLSVEHEQQ AGQRLKLPMK SNSALCDGHW HSIRVLKVKN FVTIGVDGIN
AHMQLKKQKG DHFMEEKKHT LYVGGLPENF SSIGLLMRGK HVYNIFIILL VACDRYRWIE
RIVVIVTNAS ISGKLPYSGT FLKKVALLIE TLLCVCLLLF GLSLLLCPCR LINRWGLYVF
YS
//
