ID A0A0V0TXZ6_9BILA Unreviewed; 685 AA.
AC A0A0V0TXZ6;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 08-NOV-2023, entry version 24.
DE SubName: Full=Calpain-5 {ECO:0000313|EMBL:KRX43915.1};
GN Name=tra-3 {ECO:0000313|EMBL:KRX43915.1};
GN ORFNames=T05_3641 {ECO:0000313|EMBL:KRX43915.1};
OS Trichinella murrelli.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=144512 {ECO:0000313|EMBL:KRX43915.1, ECO:0000313|Proteomes:UP000055048};
RN [1] {ECO:0000313|EMBL:KRX43915.1, ECO:0000313|Proteomes:UP000055048}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS417 {ECO:0000313|EMBL:KRX43915.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase C2 family.
CC {ECO:0000256|ARBA:ARBA00007623}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX43915.1}.
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DR EMBL; JYDJ01000108; KRX43915.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V0TXZ6; -.
DR STRING; 144512.A0A0V0TXZ6; -.
DR Proteomes; UP000055048; Unassembled WGS sequence.
DR GO; GO:0004198; F:calcium-dependent cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00044; CysPc; 1.
DR Gene3D; 2.60.120.380; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR022684; Calpain_cysteine_protease.
DR InterPro; IPR022682; Calpain_domain_III.
DR InterPro; IPR022683; Calpain_III.
DR InterPro; IPR036213; Calpain_III_sf.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR001300; Peptidase_C2_calpain_cat.
DR PANTHER; PTHR10183; CALPAIN; 1.
DR PANTHER; PTHR10183:SF416; CALPAIN-5; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF01067; Calpain_III; 1.
DR Pfam; PF00648; Peptidase_C2; 1.
DR PRINTS; PR00704; CALPAIN.
DR SMART; SM00239; C2; 1.
DR SMART; SM00720; calpain_III; 1.
DR SMART; SM00230; CysPc; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF49758; Calpain large subunit, middle domain (domain III); 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50203; CALPAIN_CAT; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00239};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU00239}; Reference proteome {ECO:0000313|Proteomes:UP000055048};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807, ECO:0000256|PROSITE-
KW ProRule:PRU00239}.
FT DOMAIN 24..346
FT /note="Calpain catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50203"
FT DOMAIN 527..644
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT ACT_SITE 79
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT ECO:0000256|PROSITE-ProRule:PRU00239"
FT ACT_SITE 250
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT ECO:0000256|PROSITE-ProRule:PRU00239"
FT ACT_SITE 287
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT ECO:0000256|PROSITE-ProRule:PRU00239"
SQ SEQUENCE 685 AA; 77559 MW; 607E3D71BD1005DC CRC64;
MAPEPFQNQR YKKLKKQLVK EGKLFTDLEF PPTNSSLYYD PKRNEGIEWK RPGDIVNNPK
LFVDGVSVND VTQGVLGNCW FVAACSALTR HKRFWTKVIP DANEQEWSSS RADKYCGIFH
FCFWRFGRWV DVVVDDLLPT RGGKLVYAQS KTRNEFWCAL LEKAFAKLNG CYESLSGGTL
AEAFVAITGG VPITIKLDSG IYYDHATARM ELFSMLKKAF NEKALMAVSI RANTLEEVEE
PLECGLLKGH SYAITEVKKL SLDSRYQSLF SSLFNTPEKV MMVRLQNPWG EKEWNGAWSD
GASEWDQISK EQQRELGLKI EENGEFWMCW EDICTNFTTI DLCYQFDTSV FSLSSRYHET
ILHGVWHCAN DKGDVLSDRA GGCANFKDSC LQNPQYRLDV LEDGGEFVAS LMQRGSGIRR
RQRTSYLTIG MILIKVGAIE TAIVFCHLEI NQSFLQVEEN RIYRLHKLTG QIVAKSDYAG
CESVLMFAKN LRRGRYVIIP STFAPHEEGE FMLRLYATWN MQATELTLDG PAPNPCSCFS
KPFKCVTQLT VVGANNLHVS NKGPINPYCV VKCDGREVRS MICKETRDPN WDLQCIFVRK
SVDKPIQIDV WSSNMVRRDA WLGRVLLNCP INNRCSSGEQ PLEEKAKKAA AADVNTSTGA
PASAVDDKQG KILYSVATYD DPIRL
//
