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Database: UniProt
Entry: A0A0V0TY64_9BILA
LinkDB: A0A0V0TY64_9BILA
Original site: A0A0V0TY64_9BILA 
ID   A0A0V0TY64_9BILA        Unreviewed;      2074 AA.
AC   A0A0V0TY64;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   27-SEP-2017, entry version 10.
DE   RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=CACNA1F {ECO:0000313|EMBL:KRX43958.1};
GN   ORFNames=T05_15844 {ECO:0000313|EMBL:KRX43958.1};
OS   Trichinella murrelli.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichocephalida; Trichinellidae; Trichinella.
OX   NCBI_TaxID=144512 {ECO:0000313|EMBL:KRX43958.1, ECO:0000313|Proteomes:UP000055048};
RN   [1] {ECO:0000313|EMBL:KRX43958.1, ECO:0000313|Proteomes:UP000055048}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISS417 {ECO:0000313|EMBL:KRX43958.1};
RA   Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT   "Evolution of Trichinella species and genotypes.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1C
CC       gives rise to L-type calcium currents. Long-lasting (L-type)
CC       calcium channels belong to the 'high-voltage activated' (HVA)
CC       group. They are blocked by dihydropyridines (DHP),
CC       phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA
CC       (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-
CC       GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing the alpha-1C subunit play an important
CC       role in excitation-contraction coupling in the heart. Binding of
CC       calmodulin or CABP1 at the same regulatory sites results in an
CC       opposit effects on the channel function.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KRX43958.1}.
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DR   EMBL; JYDJ01000107; KRX43958.1; -; Genomic_DNA.
DR   Proteomes; UP000055048; Unassembled WGS sequence.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR031688; CAC1F_C.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005446; VDCC_L_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16885; CAC1F_C; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 5.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01630; LVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Complete proteome {ECO:0000313|Proteomes:UP000055048};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000055048};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM    146    165       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    243    264       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    276    296       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    336    355       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    417    438       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    450    472       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    581    597       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    617    642       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    649    667       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    704    724       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    745    762       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    774    797       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    943    961       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    996   1019       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1107   1134       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1188   1206       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1218   1238       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1258   1277       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1284   1303       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1349   1369       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1435   1459       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1615   1649       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
SQ   SEQUENCE   2074 AA;  236857 MW;  365950FFED1358E2 CRC64;
     MHAWKEYLCW HRESRPEQVV PSPIAEPRVA SIQTMIVRQV RHHARSEANF NDDVNIGKEL
     SGNEAAALLH GDEARASRAD LWQQTLQAAV AAQTESSTTT KKRQQQRKMQ RNVQQERPER
     SLLCLGLKNP IRKLFISIVE WKPFEWLILC MICANCIALA VYQPFPAHDS DRKNAVLLCA
     IGKTFFDFVP AELRPAIDRQ PGTAFQNRKH KLNPQPGQRT ATVAAVGHTG WGVGLFSEEQ
     VEYIFIVVFT IECVMKVIAY GFLFHPGAYL RNGWNLLDFL IVVIGLISTA LSTLNIHGFD
     VKALRAFRVL RPLRLVSGVP SLQVVLNSIL RAMVPLFHIA LLVLFVIIIY AIIGLELFCG
     KLHKTCVDQW TGEHVPDPGP CGESHTSFHC DRSKNLVCTE NHTWPGPNDG ITNFDNFGLA
     MLTVFQCISL EGWTDVMYWV NDSVGREWPW IYFITLVILG SFFVLNLVLG VLSGEFSKER
     EKARARGLFQ KFREKQQLED DLKGYLDWIT QAEDIDLVNE EDEEQEAMDR EEFGADGEGG
     EEGGSKEEFQ RQSWFSMKIK RLKKLNRRCR RSCRRIVKSQ AFYWLVIVLV FLNTMVLTSE
     HYGQPEWLDH FQEIANLFFV VLFTLEMFLK MYSLGFVNYF VALFNRFDCF VVIGSILEFA
     LTFAGLMKPL GVSVLRSARL LRIFKVTKYW NSLRNLVASL LNSLRSIASL LLLLFLFIVI
     FALLGMQVFG GKFNTIDPNM NKPRANFDTF VQALLTVFQI LTGEDWNAVM YNGIAAFGGV
     HSIGVIVCIY FIVLFICGNY ILLNVFLAIA VDNLADAESL TAAEKEEENK RANEADPEDD
     MVVKATADED AVSVGQFHES GEVKLPFNEP TDAEDEHLAS GDDDQEREME NQSQFKPTAR
     PHRQSELNLP KKTKPIPDAS SLFLFSSTNK VRIFCNKVIN HSYFTNSVLV CILVSSAMLA
     AEDPLQASSF RNEVLVYGLI LHKGSFCRNA FNLLDMLVVG VSLTSFGLKS GAISVVKILR
     VLRVLRPLRA INRAKGTFIE FEGGDVTRPH VRNREWTNYD FNFDNVQNAM VALFVVSTFE
     GWPDLLHVAM DSSDEGIGPQ YNARVSVAIF FITFIVVIAF FMMNIFVGFV IVTFQSEGER
     EYENCELDKN QRKCIEFALT AKPQRRYIPK NRFQYKIWWF VTSQPFEYAI FIIIILNTLI
     LGMKHYKSSA AFDEALDVLN LFFTTVFALE FICKLFALTF KHHKMTRTFD DVLDTMNLIF
     TGIFAMEFIL KVMAFRCKNY FGDAWNVFDF IIVLGSFIDI IYGKPGSNII SINFFRLFRV
     MRLVKLLSRG EGIRTLLWTF MKSFQALPYV ALLIVLLFFI YAVIGMQIFG KIALNSNTEI
     HRNNNFQTFP SAVLVLFRSA TGEAWQLIML SCANTPAAMC DPESDDRGQP CGNDFAYPFF
     ISFFMLCSFL IINLFVAVIM DNFDYLTRDW SILGPHHLDE FVRLWSEYDP DAKGRIKHLD
     VVTLLRKISP PLGFGKLCPH RLACKRLVSM NMPLNSDGTV CFNSTLFALV RTNLKIYTEE
     RPFLFLKKSE KVESQSLVSS NIEEANEQLR AVIKRIWKRT PQRLLDEIVP PSGRDDEITV
     GKFYATYLIQ DYFRRFKKRK EVEQKETNMQ GNITMSLQAG LRTLHEIGPE IKRAISGNLE
     TDWSKEFEEP QHRRDHSLFG TLVHALQAHY KPFIEGNLTN PAYSNVNGDL KSQEGDDEAE
     QQHQQHQQEQ QEQQQQLMFN KMNDLKSPPV KSDRDKISEF ESDESVCNKP ERRCNSFFSN
     IRRRMDSIVS PSIVLFDSDH DSSEHEMQER VRFVPRGSKP TGLSFEGSRW LPRKLSFRRT
     PIGGAAAVSN LQQGNNKRLQ FSNAIILDDS DPDSVLHSEN VVDLTESGDD SKLSVSPPLE
     LRDDAYYLDG IDYNTWRPAP MGQGVRLRGR GNGRRKSRSM PLPHHEHQRN YADVLVEKVL
     ADQGLGRYAD PNLIRTTQLE IAEAYNMTEA QMHSAARSLM QRSPKYFEHM GGQRPADIKD
     FNQYSKTALL KPREINSSEE VDISDDMNMF MSVV
//
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