ID A0A0V0USX3_9BILA Unreviewed; 1533 AA.
AC A0A0V0USX3;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Guanylate cyclase {ECO:0000256|ARBA:ARBA00012202, ECO:0000256|RuleBase:RU003431};
DE EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202, ECO:0000256|RuleBase:RU003431};
DE Flags: Fragment;
GN ORFNames=T09_5274 {ECO:0000313|EMBL:KRX54390.1};
OS Trichinella sp. T9.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=181606 {ECO:0000313|EMBL:KRX54390.1, ECO:0000313|Proteomes:UP000054681};
RN [1] {ECO:0000313|EMBL:KRX54390.1, ECO:0000313|Proteomes:UP000054681}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS409 {ECO:0000313|EMBL:KRX54390.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP = 3',5'-cyclic GMP + diphosphate; Xref=Rhea:RHEA:13665,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57746; EC=4.6.1.2;
CC Evidence={ECO:0000256|ARBA:ARBA00001436,
CC ECO:0000256|RuleBase:RU003431};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC family. {ECO:0000256|RuleBase:RU000405}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX54390.1}.
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DR EMBL; JYDN01000173; KRX54390.1; -; Genomic_DNA.
DR STRING; 181606.A0A0V0USX3; -.
DR Proteomes; UP000054681; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR CDD; cd06370; PBP1_SAP_GC-like; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 6.10.250.780; -; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR018297; A/G_cyclase_CS.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR011645; HNOB_dom_associated.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR PANTHER; PTHR11920:SF335; GUANYLATE CYCLASE 32E; 1.
DR PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF07701; HNOBA; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 3: Inferred from homology;
KW cGMP biosynthesis {ECO:0000256|ARBA:ARBA00023293,
KW ECO:0000256|RuleBase:RU003431}; Coiled coil {ECO:0000256|SAM:Coils};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000054681};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 611..635
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 656..939
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 1011..1141
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT REGION 1482..1502
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 948..983
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1485..1502
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KRX54390.1"
SQ SEQUENCE 1533 AA; 172460 MW; DF063FA98E6DE0A2 CRC64;
LVEMLLLAVR REISIAVVIF ALVLVGLVRF GFAADVGPAR QRILIGYLAG TVINRQPPIL
LKFQIPSAPV GLGQNNNTTS RRNVSTTLDL LRSIVGASNN TGTRMANDRR RRQGSTLFDH
SDHRLVGGGH SNLDCNFSGH VLSAHTMSLE RIAKCLQRQG LVHLSRNLQG HIISGALKYA
IEIVNANPDI LPGYQLDFIF ADTRGLTKQS VKATMELWQK GVIAFIGPED SCQTEAMMAA
SQNLPMISYK CFDHAVSDKS KYSTFARTVP AETEIGRAAI SLLKHYSWRK FAIVYGHNDV
NSHLLKTVVE LSTAEGLHIL NISRFEEPYR STNFDDRQRI SEIVSETHLK TRIYLMFGSV
SALQQMLYAM DDLELLNNGE YVIIYLEPSY TYLNPDDAMM NYFYRATLYT VEEFHNYPFV
NRIVDLSRSV LAIIPSPVTF TDKAWQEFWE KVNQYNAQPP FNFFNPVGNS HIGKYPVVNR
YATYLYDAVM LYATALHEEL QAGGDPRNGS SIIGRIFNRR YQSMQGFEMQ INEQGDAEGN
FTLLTRQRLV DSRFNLTYGL IPSAYFIEKN ETLPGLLFKR GLRVDWAGGK PPQDEPECGF
RGEYCVDQPS YAVEIVCGAI GIVMLIMAVV SFIYYRNRKY EQELAGLIWK INPKEIQFHP
CTGYDNLGGS RATDFSSWVV DPHGLGVYRG SLVAIKEIRY AKRTREITRA TKIEMKKMRS
LHHDNVNRFI GIIVQPNFIC VVREYCAKGS LFDVLLNENI KLENMFIASF VDDLLKGMIY
LHDSEIRVHG NLKSTNCCIT SRWSLQVSDF GLSELREGQI YMSQESQLMG LLWTAPELLR
ESVDHMQPCK GTQRGDSYSF GIVLHEVFSR NGPFDVYYED SLSGEEILKN IIHTPYFRPS
LALVECDKYI SDTMLACWDE RPECRPDFRQ IRMRLKMLFK GIMKQNIMDH MMGMMEKYQS
HLEELVEERT EELKEEKKRT ETLLHRMLPK VVAAQLMQGK DVVPETYDSV TIYFSDIVGF
TALSAESTPV QVVAFLNDLY TLFDRIIRQY DVYKVETIGD AYMVVSGLPI RNGNQHAGEI
ATMALELVEA VKAFQVPHKP DVACLLRIGI HTGPCAAGVV GKTMPRYCLF GDTVNTASRM
ESNGMPLKIH CSESTKLALD KLGGYLLDER GLIPLKGKGE MRTYWLLGKQ EAVVSSRPSE
ANVEEPLFSS SRFVRPCSVK QRSRETSMIS IRMENARSKI RRENTILENA SVSAERTAQP
FAAGNDLKML GKYPMKCRRR ESAKQAPNRI ADDFINRKRS NSYPENIHSL TAKGGTSAPT
LRNTTLLTNP LYCSTQPSSS AASSGQPLTL IIDSKDSSGG IIPTLADGRP GKRNSREDRS
TCKFPVKRHS CSGPRVPRTK LNGMSISMDE FALPEHTPWR AHGNLWQVAS NRSERADMYD
PLPNTCNGAE SISGSYPEEC GVNCPLLEPV EYFENAKVAD RQFRKDSSSQ PSNSPMASAS
HSDSAASLWM RFLKSSMSGG SGEINAEQQP GIA
//
