ID A0A0V0UUH7_9BILA Unreviewed; 3979 AA.
AC A0A0V0UUH7;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=prkdc {ECO:0000313|EMBL:KRX54920.1};
GN ORFNames=T09_733 {ECO:0000313|EMBL:KRX54920.1};
OS Trichinella sp. T9.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=181606 {ECO:0000313|EMBL:KRX54920.1, ECO:0000313|Proteomes:UP000054681};
RN [1] {ECO:0000313|EMBL:KRX54920.1, ECO:0000313|Proteomes:UP000054681}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS409 {ECO:0000313|EMBL:KRX54920.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX54920.1}.
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DR EMBL; JYDN01000158; KRX54920.1; -; Genomic_DNA.
DR Proteomes; UP000054681; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004677; F:DNA-dependent protein kinase activity; IEA:InterPro.
DR GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05172; PIKKc_DNA-PK; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR037706; DNA-PK_dom.
DR InterPro; IPR046804; DNA-PKcs_N.
DR InterPro; IPR046803; DNAPKcs_CC1-2.
DR InterPro; IPR012582; DNAPKcs_CC3.
DR InterPro; IPR045581; DNAPKcs_CC5.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR014009; PIK_FAT.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF68; DNA-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT; 1.
DR Pfam; PF20500; DNA-PKcs_N; 1.
DR Pfam; PF20502; DNAPKcs_CC1-2; 1.
DR Pfam; PF08163; DNAPKcs_CC3; 1.
DR Pfam; PF19704; DNAPKcs_CC5; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM01344; NUC194; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 3.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:KRX54920.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000054681};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 2756..3380
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 3559..3893
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 3947..3979
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
SQ SEQUENCE 3979 AA; 455892 MW; AEDD9E976EBF26DF CRC64;
MAYSTVDQIR DALNSLKDFI EGADSDQAED CVQQIFEHFR KLSGSERNFG FCFNSLLSND
SNSLLSILSS SIGKTAFAQT IGYGIDIIRL AIAKTTSLSP SHRKAIMRFT LRLLKQDYLK
GRRENVLYLV NECIKYSSVL STEGGELNFC YDELLHCCLA LIDSLKKLQS GVKKGLFIII
GTLCQEIPEK LITADHNYAL LFANIMSEEL KNQMCSSIHS PSYSVIEGCF LGLNDLLAHF
SNLFDGACRM SCSELFCLIK KACNPKNDVH RLGHLKAALG LVISHVQFFR HHFLDEYSLL
NEYFSHWAKH SDREIKTYSL NAEDLLIREL ATELITKVDS DPNHVRSVYK YFCNQFDEVF
SNTSGIREIS MISKSYGRLF QIGKALYGEE EVCKILRKLL QRFEYLSTTS SDAQQQKVYH
ITNILETASR GLICLSKIAD DVWQLMERFH VTLFHNFPLM EKRFYHRCKV INFATFAAAY
GHNYQYIQSI VFQSLIRVIA SLPSVGKESI VLPKDENAFY LADYLPFWKM LLDSEFVDLS
EFGFDRSMQV NIRRTFFDCF MKSFLEIVRL LSFETKAFQD VEEYTFRFSN PILHVIPTKQ
ADYDLFYNLV ELCRSVIMKG SHVLFEPWLQ PMLTMLLELS SRYPMVSGFY KLLALWVTMA
EKLNYFNSTK QDDKTENCSS HYKLLLSDFI DHVLVESCRF QGELLVSCLR FLLALPTCIV
VEKLESIKES IKSSLKLGLN YLPIACVCLD ALEKWSAEFP EDEPQLDSFY TDLLPIFDDY
LRCTSVDETL VSNNGFNYNG EKSALFNRKR NSGNVFDKSD DNDSEEEIPN PQTVLRRIAS
FVGSLGCYMN RFLINSADAG SLLRWGHGSH LEFICPFPDM KFEIALDTLL PRLCDLALSA
GDRPLKVAAC EALHACVLFL LGNESFRTVK VRDRESISKA YSHIFPVLLK LACDVDEVPK
QMFSTLFVQI LHLFSGTDFA DKIVTSCLLD TLMDGLCCFW NSSLRDQSAY YISEYCRWSM
RRVDNTGQNM HSESKVELLV QTIITFAVHS SAVKRAGAAV AFNNLYKIIR EKRWLVDIYI
LEMFFTFMKS LYLAENDDEL YGTVDECKQA IKHIRRIILY NLNMLRIHNE RRRTPNEWSQ
STIHCCCDWL LNTMTWSNYQ FRSECFVSYQ ELTNAGLEIE KLHFLRHIGT SIFGLIDHFE
RSHRSVLGSF SICNLQDRVA TGTSIYALVL WLETYEAMID GYVWALNTNR ISMEDWNNYL
LNEHPRMKSL LFPCSMDLVN SIVIGRNFPN ISKTQRNRLN KTRCKCFVAL CKLISALVNC
PNLNNFQGFL KLLLYPNTWN AFLKVACDPK SLGFRLYSKQ LFECISQDVR LLFLALKNNT
FLVQQVSTNM KEYLTQFYPW PDVESVVTCD SHLAIEQQQL LNVYGMLVEV GLRCVVELPG
AEFLWTTVAD VYFSKRIGLP PSKLGMVKQI FRVAALTGSA VDVLIKLLMN TESVRLAECS
TLCSTKGELL IANFGEEIAL LLCTNAELFL KHLKEASRCQ PDVVGRALLH TVTVVVHSSD
LRKKYGRKLA LQVLRIFGQE LLHWADVAVS NETLKLLWLK LIMKLILIDS KITEWQEFAP
MASAYFMMLN DQSLTLDFKN NMLSLLAGFC TFDKHASELG KSLKLFMVNN FPLKSDEFAK
GTAKYDQYVA ACQKILFAFG CTGSPLILEL LLNMICREQS HPIASDLKHQ LQKFSSRTSR
AVLENILVLL DEMFFNPSSC VCSSLRLALL NEFFIPFLHS LKSDLLLSWT CRRIQTLVSC
LTESSISEIK TDYEEQIITR IGCYKIFEII YKVLDLEFLK TEVNSSYLGS DSQMKNELIK
KLVSCAVGAK KEFCRDSKLG SVQRHFFEYR CAAQNCIIAL VKKTQSHLKH YEGFIFNDCW
ESIIDNEVKY EFDREIQEEE QSAGKMYYSR EEKPPSAESE NQVELSVLLD SSLSVMATQF
DLTESLEASI HCAEKETESA NDKDVLRFYS KTKLDFLDQH PCMMSMVDVI NYMDQMDMIP
NAANTPLPAW MASMRDFLNF GSINVRLFIA RIIVQCFHVF RPFYLEWISP IIKLIVMDEF
GSNILHYFRV DLIVVLFEWT AHVKKDEAIP KDSLNDLLKF CVQHCCSKSG KVFKRNLRII
ETMLVLWKPF VTLDPSWILE KICFPLHDEM ENLCGISILC LCLNTVPETF SFLTDPNHES
GIFSHLIGLL SLNKVKVYKL AAFVCGLSLK VLNETDCEWL LKGMKTVMSR MTGTVVGRSK
CLLCLHEILP NYPEFALQFF NDLLDWFPSV QGDLKTACLE GFLAVSKYKG DLFEELKSRG
FLKIFSLRHE RDQMLGMYIV KNIHANLSVE NISDLVSSFS SVVVGNFSSS CRRAFAEMCC
SLYTKLSSLN DSSENSKTAL ATTKMHLLTM LSDSNKSIRQ LVYNFWCDAS RLEISTSARL
LNCLSQLYTC ATESTFLSHA SYVMLELTCH SPDYTRLIYD HPLEDCTFEN LPISTHWQSR
YASLEVPAYM QTDTHSVQQA VSQFISRKRK IPYGRTFSTE STASSSFTST AVTDLKKNVG
NVSADTFELD FDESDSSDNL TVILDKILQD IKKPKSSSVK KVDDLDGDLQ FLKNRILKDT
EEKAFFVNLD RKRQKVIERL KQQSLDLRGK YRSGDFPDIQ IPYSAVIITL QAVAELDKVF
AGQLFESLMY GVVAHSINDG VREIFRSMVT FHRPLVSCLM NFLYNFIEYV DFEPTDIANV
AIGSGQPDCG IVLLERRIEV AFEDTTASTS HEWRPKHVNE IDQLWVELSR LYKQCGELEN
LRAVFTKHLL TAEETKLALE MEAAGDFEGA AAIYGETFNN KKRKSGGIVE KAEANLLYEA
RIRCLEMLND WKGLEAWSTT FGSTGQTTKL DQIWETDYLI NMHLPVFLRS KLKIALTSDS
VALEELSTFV EQNQSVPKNR EILENRHSGL LVLLNILREN FTKSQYFLSL SMDSFLKCYP
TLRVCDVTAR LKLVQDLLPV SETAKFLHLL HASDEFKLEN VVKLCRFWLR YGLDVETTLT
TTADDVVLNR KTFLEIFGKR LVDSGISVSN VQQSLLPFRL QFGYQYLKCA VRQNNHGVLL
QRLQDKHLLL EASNYETWAL LQLANCANAV KSRTAYLMQA LKLFDLKKIT DPELNTTESS
SADQFALIGM LFDNVAETVV ASSENTLAEF CLSRLFSNTD TAADISELVT LCYDQAFRYL
KLSCQYSSVQ SNIESPKLTE PLMELSSFCD RILRKNGHTS LVNSECACVM VRSILMSMKN
GSHLARQLFP RLLSVMEKYP ESELEFQAEI DSVPSWMFLS WLNQMLSALK RSNKFYSILE
RIADDYPQAL IYPLLMLKSA TGDAGETDFY RLQLKLRKTK IVKDFIDALT LLSHPDMHVI
DELESIIMNV SNKSNEARRE TMVKLYSFVT FADIRKEFLG SFWKCHFQKF LPKIQEIFCV
DICTFDSKAA ENYLRLCSSI LNELRTFYIP ECCPNNLNEY SPWLTAYRPH PLDVFLEIPG
QYSGDRRPFP ERHVHIIGFA SDVEIMRSLK KPKKICIQGD DGRDYKYLVK AGEDLRQDER
VQQLFDLMNG ILQKQHQCSR LKARIRTYRI VPLSIKLGLI EFLPNVVPLQ QFFMGESLRK
EYQTIAMDMF TEGPGKILLK AAGEASSPLN HMTYWRSFQN ISPETAARRF SEVVKKIPDH
LLRDQLLNCC VSPDVFCFLR QKFTVSLAIM SIANYLLEIG DRHLGNIVLD TKTGEVIGID
FGYAFGASLQ YLPIPELMPF RLTKQFVGVV EPVGMHGLLE STMKYCLKAF RDSSYILLNT
MDTFIKEPSL NWIVEVRRQI GEGRPLWNDE TNLRDLFKWY PEEKISAAAR KLRGDNPVII
MQDELMNSRQ HLSSFPLHQI INCIYGKKDF SALTEEEQSA PRGYPLQALT VEQQTSCLIE
MATDPIILSR TWFGWEAWI
//
