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Database: UniProt
Entry: A0A0V0V379_9BILA
LinkDB: A0A0V0V379_9BILA
Original site: A0A0V0V379_9BILA 
ID   A0A0V0V379_9BILA        Unreviewed;      2203 AA.
AC   A0A0V0V379;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   27-SEP-2017, entry version 10.
DE   RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   ORFNames=T09_15523 {ECO:0000313|EMBL:KRX57983.1};
OS   Trichinella sp. T9.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichocephalida; Trichinellidae; Trichinella.
OX   NCBI_TaxID=181606 {ECO:0000313|EMBL:KRX57983.1, ECO:0000313|Proteomes:UP000054681};
RN   [1] {ECO:0000313|EMBL:KRX57983.1, ECO:0000313|Proteomes:UP000054681}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISS409 {ECO:0000313|EMBL:KRX57983.1};
RA   Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT   "Evolution of Trichinella species and genotypes.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1C
CC       gives rise to L-type calcium currents. Long-lasting (L-type)
CC       calcium channels belong to the 'high-voltage activated' (HVA)
CC       group. They are blocked by dihydropyridines (DHP),
CC       phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA
CC       (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-
CC       GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing the alpha-1C subunit play an important
CC       role in excitation-contraction coupling in the heart. Binding of
CC       calmodulin or CABP1 at the same regulatory sites results in an
CC       opposit effects on the channel function.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KRX57983.1}.
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DR   EMBL; JYDN01000092; KRX57983.1; -; Genomic_DNA.
DR   Proteomes; UP000054681; Unassembled WGS sequence.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR031688; CAC1F_C.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005446; VDCC_L_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16885; CAC1F_C; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01630; LVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Complete proteome {ECO:0000313|Proteomes:UP000054681};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054681};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM    263    284       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    296    316       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    356    375       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    437    458       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    470    492       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    601    617       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    637    662       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    669    687       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    724    744       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    765    782       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    794    817       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    963    981       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1001   1025       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1037   1063       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1098   1117       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1208   1235       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1289   1307       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1319   1339       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1359   1376       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1388   1406       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1452   1472       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1538   1562       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1718   1752       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
SQ   SEQUENCE   2203 AA;  251593 MW;  683DC3A6ED5EBE0D CRC64;
     MLAGGETLLQ IEFSWLLWSR RRSRASYLCW HRESRPEQVV PSPIAEPRVA SIQTMIVRQV
     RHHARSEANF NDDVNIGKEL SGNEAAALLH GDEARASRAD LWQQTLQAAV AAQTESSTTT
     KKRQQQRKMQ RNVQQERPER SLLCLGLKNP IRKLFISIVE WKPFEWLILC MICANCIALA
     VYQPFPAHDS DRKNAVLLCA IGKTFFDFVP AELRPAIDRQ PGTAFQNRKH KLNPQPGQRT
     ATVAAVGHTG WGVGLFSEEQ VEYIFIVVFT IECVMKVIAY GFLFHPGAYL RNGWNLLDFL
     IVVIGLISTA LSTLNIHGFD VKALRAFRVL RPLRLVSGVP SLQVVLNSIL RAMVPLFHIA
     LLVLFVIIIY AIIGLELFCG KLHKTCVDQW TGEHVPDPGP CGESHTSFHC DRSKNLVCTE
     NHTWPGPNDG ITNFDNFGLA MLTVFQCISL EGWTDVMYWV NDSVGREWPW IYFITLVILG
     SFFVLNLVLG VLSGEFSKER EKARARGLFQ KFREKQQLED DLKGYLDWIT QAEDIDLVNE
     EDEEQEAMDR EEFGADGEGG EEGGSKEEFQ RQSWFSMKIK RLKKLNRRCR RSCRRIVKSQ
     AFYWLVIVLV FLNTMVLTSE HYGQPEWLDH FQEIANLFFV VLFTLEMFLK MYSLGFVNYF
     VALFNRFDCF VVIGSILEFA LTFAGLMKPL GVSVLRSARL LRIFKVTKYW NSLRNLVASL
     LNSLRSIASL LLLLFLFIVI FALLGMQVFG GKFNTIDPNM NKPRANFDTF VQALLTVFQI
     LTGEDWNAVM YNGIAAFGGV HSIGVIVCIY FIVLFICGNY ILLNVFLAIA VDNLADAESL
     TAAEKEEENK RANEADPEDD MVVKATADED AVSVGQFHES GEVKLPFNEP TDAEDEHLAS
     GDDDQEREME NQSQFKPTAR PHRQSELNLP KKTKPIPDAS SLFLFSSTNK VRIFCNKVIN
     HSYFTNSVLV CILVSSAMLA AEDPLQASSF RNEVPKFVLN YFDYFFTTVF TIEISLKVLV
     YGLILHKGSF CRNAFNLLDM LVVGVSLTSF GLKSGAISVV KILRVLRVLR PLRAINRAKG
     LKHVVQCVIV AVKTIGNIML VTFMLEFMFA IIGVQIFKGS FFRCTDRARL TAEECKGTFI
     EFEGGDVTRP HVRNREWTNY DFNFDNVQNA MVALFVVSTF EGWPDLLHVA MDSSDEGIGP
     QYNARVSVAI FFITFIVVIA FFMMNIFVGF VIVTFQSEGE REYENCELDK NQRKCIEFAL
     TAKPQRRYIP KNRFQYKIWW FVTSQPFEYA IFIIIILNTL ILGMKHYKSS AAFDEALDVL
     NLFFTTVFAL EFICKLFALT FKHHKMTRTF DDVLDTMNLI FTGIFAMEFI LKVMAFRCKN
     YFGDAWNVFD FIIVLGSFID IIYGKVSPGS NIISINFFRL FRVMRLVKLL SRGEGIRTLL
     WTFMKSFQAL PYVALLIVLL FFIYAVIGMQ IFGKIALNSN TEIHRNNNFQ TFPSAVLVLF
     RSATGEAWQL IMLSCANTPA AMCDPESDDR GQPCGNDFAY PFFISFFMLC SFLIINLFVA
     VIMDNFDYLT RDWSILGPHH LDEFVRLWSE YDPDAKGRIK HLDVVTLLRK ISPPLGFGKL
     CPHRLACKRL VSMNMPLNSD GTVCFNSTLF ALVRTNLKIY TEERPFLFLK KSEKVESQSL
     VSSNIEEANE QLRAVIKRIW KRTPQRLLDE IVPPSGRDDE ITVGKFYATY LIQDYFRRFK
     KRKEVEQKET NMQGNITMSL QFGEEFPSDL EAFDVLIVFL HVLLLQAGLR TLHEIGPEIK
     RAISGNLETD WSKEFEEPQH RRDHSLFGTL VHALQAHYKP FIEGNLTNPA YSNVNGDLKS
     QEGDDEAEQQ HQQEQQEQQQ QLMFNKMNDL KSPPVKSDRD KISEFESDES VCNKPERRCN
     SFFSNIRRRM DSIVSPSILL CRVLFDSDHD SSEHEMQERV RFVPRGSKPT GLSFEGSRWL
     PRKLSFRRTP IGGAAAVSNL QQGNNKRLQF SNAIILDDSD PDSVLHSENV VDLTESGDDS
     KLSVSPPLEL RDDAYYLDGI DYNTWRPAPM GQGVRLRGRG NGRRKSRSMP LPHHEHQRNY
     ADVLVEKVLA DQGLGRYADP NLIRTTQLEI AEAYNMTEAQ MHSAARSLMQ RSPKYFEHMG
     GQRPADIKDF NQYSKTALLK PREINSSEEV DISDDMNMFM SVV
//
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