ID A0A0V0VE66_9BILA Unreviewed; 2489 AA.
AC A0A0V0VE66;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=Phosphatidylinositol 4-kinase alpha {ECO:0000313|EMBL:KRX61748.1};
GN ORFNames=T09_792 {ECO:0000313|EMBL:KRX61748.1};
OS Trichinella sp. T9.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=181606 {ECO:0000313|EMBL:KRX61748.1, ECO:0000313|Proteomes:UP000054681};
RN [1] {ECO:0000313|EMBL:KRX61748.1, ECO:0000313|Proteomes:UP000054681}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS409 {ECO:0000313|EMBL:KRX61748.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) +
CC N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:60344, Rhea:RHEA-COMP:15554, Rhea:RHEA-COMP:15555,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; EC=2.1.1.361;
CC Evidence={ECO:0000256|ARBA:ARBA00000350};
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. Type III PI4K
CC subfamily. {ECO:0000256|ARBA:ARBA00006209}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX61748.1}.
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DR EMBL; JYDN01000045; KRX61748.1; -; Genomic_DNA.
DR Proteomes; UP000054681; Unassembled WGS sequence.
DR GO; GO:0140944; F:histone H4K20 monomethyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05167; PI4Kc_III_alpha; 1.
DR CDD; cd10528; SET_SETD8; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 1.25.40.70; Phosphatidylinositol 3-kinase, accessory domain (PIK); 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR016858; KMT5A-like.
DR InterPro; IPR047266; KMT5A-like_SET.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR001263; PI3K_accessory_dom.
DR InterPro; IPR042236; PI3K_accessory_sf.
DR InterPro; IPR045495; PI4K_N.
DR InterPro; IPR015433; PI_Kinase.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR PANTHER; PTHR10048:SF15; PHOSPHATIDYLINOSITOL 4-KINASE ALPHA; 1.
DR PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF00613; PI3Ka; 1.
DR Pfam; PF19274; PI4K_N; 3.
DR Pfam; PF00856; SET; 1.
DR SMART; SM00145; PI3Ka; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR PROSITE; PS51545; PIK_HELICAL; 1.
DR PROSITE; PS51571; SAM_MT43_PR_SET; 1.
DR PROSITE; PS50280; SET; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:KRX61748.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000054681};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 248..370
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 1926..2104
FT /note="PIK helical"
FT /evidence="ECO:0000259|PROSITE:PS51545"
FT DOMAIN 2200..2473
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
SQ SEQUENCE 2489 AA; 282288 MW; 7441AC89AD39FA68 CRC64;
MSSSGLKAFF KTQKVAAIDD VDSKKLYEIS NGKLAVEQKT DDPNCDNVKR EKCSKVKIKS
GKSKVNNNQK LSFVQISTTC NRATVESTEQ RDLIEVEKQL SKKNTREASS IKTTVGKKEP
RQLEKRTVAA NKKRVVVQSG SLPILLSTDH HDTDHNRNDL LKSSTSPNGV PVVEAVGEVK
IENGENLIRT STKIGNSKKN STKKKNSCNS RQITEFFTVR KSGRKTASEL QEEKFDKLKK
AILSVCQDGL EVCEFPVKGR GVIATKKFYR DDFVVEYRGE LIDINEAQRR ERDYQNSSQV
GCYMYYFSYK GKRYCVDATP ESSHFGRLLN HSAKDPNVKS KIVNIDDNPR IIFVAKRDVE
IGEELLYDYG DRRKDAIRAH PWLVERIFIH CPQRDADQYV VTNDALNALI ALGIFCFESN
FQHDKKIIPY IISLLENLMT TNFVYTGAES VKFSALMFFK FLHYLLTFFF CLETILAEKY
VFYLNCILNE IAWRNESWKE NIFRAQFDIF DSMCSLCKSL LTKNDLTMEE KISLIRTVCL
LVGFFRCFGR CSAMDKAALI CQIFPQKLTA VAKDLSQKSS TFDFQQKSVL PSETAIPFVL
IKSVPLAKSD KEAKQSNGDK YYAKFREQFQ SAIQLSNERY FIADVSNIDL KQFQIILDKL
TNFLNSELLT KLDIYAMDIH MDGKLLHFTY SSISEIVVLV QLSFLKDCVQ SFANNHILDD
QITGSDLQKQ IMKFVLNCFT YSQMDLNAKH DSTSKKVYVE NVQKFKNLAL SNGLAVELLV
MVIDETEADN VCYRIIENLN NIHGHRILSA QVLLILVSLD ALGCLAERFP CLSTTVIVSS
LLNFLTDPSP ALLKLYDLHK KRENSDLLKK KNTARQSEMN CIQRFSSDFE KIRQTAINSL
CRGLKNGLSV DLECINACLA SISTSLYVAK TGEQHSGLIM QNAIFALGGM GVWLCDMPSV
SSDILQIFQQ KFTNPVSSMD VLIIHQLSEM ILAGCTVIYS EVMKMFNKVT MESWSSSYTS
SEDSGGNIYR HVSLAVINAF YNLAENIEGE AQKNDLLIRL LELFVQLGLE GKRISEKISS
TAVKASSNAG NLGVLIPIIA ALMRRMSFIA DPRPRLHKLF RDFWSYCVVM GFTVECSGLW
PQTWYDGACT IAENSPVLIF TDNLRLLVKG SAISSDSVNP TDLQELRNSL LSQLGHPAEV
VALVNKMEFA QCVYLLAVLR LETLRSVYSE NSTAVHLIFG YLREKQAWHF FISSFLFQII
FFFLQSYSYF SRSIRKDKSG IWTCMIAIAL QVFKQYVRSA EQRRGDCRLK ADLERHAQFL
LVEFNSVFPE IRKCADRCLS LLVDTFPHLL WDRTLLHTIL VILQLLHQST SGDPNIDCKQ
LPVMDLPWNI CLTDTVEERR KVCNDFAAKC QQILQEAITW APSVTRSHLQ QYISSRSVSA
VSYLKHHHGL SLTVQSLLDA AQHHVCKAAL LTDVESTSCF VSSISIQNYH LGEVGGMLAE
MLPSGQSVGS LADRLLAEYD RACREDDLEL LKRSLMRICA LFILEKDVCR RLLKSICCAP
VNRYCEEVME LSVSCWEWIL TAKPEIEIEF FQELSYAWKL LADLKLGIFR EDPPLFDPSA
VHGENQLNPN PPLVKPHKIL IRFLSENISV AKFCNQDLVD IFLIIFMQSL NLAIGSGPGV
TVKDVYFHNV ATKGCLFSRH VAAVGARFHF LTSALGLLQS GSFTCGTVKC LLRKRIFAVA
LDYFAVAPQC PTQDSNALSE DISLLINFWK AVHADRKYLN RNMFGNFDNY TVDSGKSQPS
VVRIQDQSLG RAESVQSHRS GQSNFPITAS FSASQRYWAN IATLTSYRKP PIRNQANTMK
FADDFLENSL REFLRNRNLI LNLVGNEIER LVAWYNPQGL PEKVLPGEDI VEQFRMKIFP
DLIAENKIMK DCVRLLWDIC PTIAIYIPAR FKNLESVKSE LGRLVKSNPA LVRHIPAALP
YLATVQTIEN NGSELDHMLM WAPVSPACAL SFFSRQYPSH PTTAQYAIRV LKEYHPSVLL
SYIPQIIQAV RYDPFNCVAE FILSMAKKSQ LLAHQFIWNM QTNMYLDEEG KQKDPVLYEK
LNSIMADLIN SLSGEAKRFY EKEFQFFGEI TAISAEIKAF PKGQERKDAC LRALSRIKVV
QGCYLPSDPE AVVVDIDYSS GTPMQSAAKA PFLARFKVKR CGGEQVEKLG QEAIDESVDA
NDNEQPSDIF WQAAIFKVGD DVRQDMLALQ LMELCLHVFK SIGLNVYLYP YRVVATAPGC
GVIQCVPNSK SRDQLGRQTD FGLYEYFLTK FGDETSESFQ NARRNFIQSM AAYSVFSFLL
QIKDRHNGNI MLDTEGHIIH IDFGFMFESS PGGNLGFEPD FKLSGEMVAI MGGKMEAAPF
RWFMDLCVKA FLAMRSHRET FSSLISLMLD TGLPCFRGRT IQLLQDRFAP HKSEKEAAQY
MLQIVRNCFL NLRSKMYDQL QYFQNEIPY
//
