ID A0A0V0VPG6_9BILA Unreviewed; 1830 AA.
AC A0A0V0VPG6;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Voltage-dependent calcium channel type A subunit alpha-1 {ECO:0000313|EMBL:KRX65399.1};
GN ORFNames=T09_8928 {ECO:0000313|EMBL:KRX65399.1};
OS Trichinella sp. T9.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=181606 {ECO:0000313|EMBL:KRX65399.1, ECO:0000313|Proteomes:UP000054681};
RN [1] {ECO:0000313|EMBL:KRX65399.1, ECO:0000313|Proteomes:UP000054681}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS409 {ECO:0000313|EMBL:KRX65399.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU003808}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU003808}.
CC -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit (TC
CC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX65399.1}.
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DR EMBL; JYDN01000017; KRX65399.1; -; Genomic_DNA.
DR Proteomes; UP000054681; Unassembled WGS sequence.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 6.10.250.2180; -; 1.
DR Gene3D; 6.10.250.2500; -; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR031649; GPHH_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR014873; VDCC_a1su_IQ.
DR InterPro; IPR002077; VDCCAlpha1.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR45628; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1.
DR PANTHER; PTHR45628:SF7; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1.
DR Pfam; PF08763; Ca_chan_IQ; 1.
DR Pfam; PF16905; GPHH; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR PRINTS; PR00167; CACHANNEL.
DR SMART; SM01062; Ca_chan_IQ; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
DR PROSITE; PS50222; EF_HAND_2; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PIRSR:PIRSR602077-1};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673,
KW ECO:0000256|RuleBase:RU003808};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|RuleBase:RU003808};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR602077-1};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000054681};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU003808}.
FT TRANSMEM 65..85
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 97..118
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 138..164
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 205..226
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 238..260
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 383..401
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 413..434
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 508..530
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 717..735
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 755..775
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 784..803
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 850..872
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 963..987
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1045..1063
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1075..1095
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1155..1184
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1254..1278
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1294..1329
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 1805..1830
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 219
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 562
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 935
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
SQ SEQUENCE 1830 AA; 209084 MW; 7C5A8AE24B152F7C CRC64;
MTLPGWPVNG QSFNSTRNRW TVPPTSQAKL VESRVNVAMV KVPLHFSFSP KIISSAATPE
ATEPYFMGIF TIECLLKIIA FGFVMHKGSY LRSGWNILDF IVVMSGVISM LPFTTSGVDL
RTLRAVRVLR PLKLVSGIPS LQVVLKSILC AMAPLLQIGI PVAIGNKPFP CTNKSTTGAY
HCPEGTTCKE QWIGPNYGIT SFDNIAFAML TVFQCITMEG WTNVMYYTND SQGDTFNWLY
FIPLIILGSF FMLNLVLGVL SGEFAKERER VENRREFLKL RRQQHIEREL NGYLEWICKA
EEVILNEERT TEEERKAIME ARHLAVSKQL KHLVQQSTET EDDLEEEDLD VEFRTKDLSQ
TGKCWLVVRR LRVFVRRFVK TQFFYWLVIT LVFLNTVCVS IEHYGQPQWL DEFLYYAEWT
FLGIFLFEML FKMFGLGIGT YFQSSFNIFD FVVITGSLFE VIWEELKGGS FGISVLRALR
LLRIFKVTKY WTSLRNLVVS LMNSMRSIIS LLFLLFLFIL IFALLGMQLF GGEFNFPEGR
PSTHFDTFPV ALITVFQILT GEDWNEVMYL AIESQNDTLL NVFLAIAVDN LANAQELTAA
EEAHEQEVQS TYSSADIKND ECEYEKGPKM IENLSQNGQA KLTDACDAVC DVKNTLNIQE
NKTVTSDPLC YVNSIDESDS NCAFGGHREI VPYSSLFIFS PKNRFRIFVH KIVCTKYFEM
AIMVVICLSS ISLAAEDPVD ESNPRNKYLN YLDYAFTAVF TIEMILKVID MGVIIHPGSY
CRDLWNIMDA TVVICALVGF AFVDSTKAGK NLSTIKSLRV LRVLRPLKTI KRIPKLKAVF
DCVVNSLKNV FNILIVFILF QFIFAVIAVQ LFKGKFFYCT DRTKRFEQDC QGYFFHYDKQ
GSPPQVVQRE WTSFALNYDN TIHAMLTLFT VTTGEGWPGI RQASIDATEE NQGPIPFNHI
EVALFYVVYF IVFPFFFVNI FVALIIITFQ EQGEAELAEG DLDKNQKQCI DFALNARPVC
RYIPEDKDSI KYHIWKMVVS TPFEYFIMAM ICLNTIILMM SYYQEPPAYR AVLRYLNSTL
TAVFTVEAIL KILAFGVRNY FKDGWNIFDF ITVIGSITDA LVTEFGGNFV SLGFLRLFRA
ARLIKLLRQG YTIRILLWTF VQSFKALPYV CLLIGMLFFI YAIVGMQVFG NIELNGDTEI
NRHNNFQTFF NSIILLFRCA TGEAWQEVTL ACIANRKCDP RTGKLNNECG TNFAYVYFTS
FVFLSSFLML NLFVAVIMDN FDYLTRDSSI LGPHHLDEFV RVWAEYDPEA TGRIHYTDMY
EMLRNIPPPH LIRMNMPVDE DGTVQFTTTL FALIRESLSI KMRSADEMDR ADMELRKTLK
KLWPIHAKKN LTDLAVPPNS KLCNKKLTVG KIYAGLLLLE NFRSKRCGRV PDRSTFLFGR
LVDAALKEKE KIHSSEADPS SCTEFFSDSE PPRSEIRYGF EHQRRMLPTA EQPRIFDIPG
KWQTHDEMNS QMQSIYVPQD EYNNERVQHR RKVLRRQQED DHKALSERAN LDHYYVTGLA
DAKSHHESAS NVLFNQLSPV LGHSFSPAFV EKIPSPACYF HQQLPMVWEN PVTNKFSEVS
HLKAHPMFKS SPELQQCVGK RKRLAAKTAR TFCTSTIRPH REVENYAEFL QLSDDESCNY
SARSAKQTVF DSNLMSPLTV SPDPAFFSSS SSSSDASFVN VTCPAQQNVN TSSYASYCQI
SPDNSYIFAG NPTSSGEHPV RSSQSSGATY KLSGYKTAGH CQPALKEPNQ QRLYCMRSNG
PNADEHRCHS VVHSQPGHIP LSDSEQEDWC
//
