ID A0A0V0VQ76_9BILA Unreviewed; 1630 AA.
AC A0A0V0VQ76;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 08-NOV-2023, entry version 30.
DE SubName: Full=Ras GTPase-activating protein gap-2 {ECO:0000313|EMBL:KRX65626.1};
GN Name=gap-2 {ECO:0000313|EMBL:KRX65626.1};
GN ORFNames=T09_13555 {ECO:0000313|EMBL:KRX65626.1};
OS Trichinella sp. T9.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=181606 {ECO:0000313|EMBL:KRX65626.1, ECO:0000313|Proteomes:UP000054681};
RN [1] {ECO:0000313|EMBL:KRX65626.1, ECO:0000313|Proteomes:UP000054681}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS409 {ECO:0000313|EMBL:KRX65626.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX65626.1}.
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DR EMBL; JYDN01000016; KRX65626.1; -; Genomic_DNA.
DR STRING; 181606.A0A0V0VQ76; -.
DR Proteomes; UP000054681; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR CDD; cd04013; C2_SynGAP_like; 1.
DR CDD; cd05136; RasGAP_DAB2IP; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194:SF125; RAS GTPASE-ACTIVATING PROTEIN RASKOL; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF00616; RasGAP; 2.
DR SMART; SM00239; C2; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000054681}.
FT DOMAIN 533..651
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 711..903
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 1172..1214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1301..1368
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1531..1562
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1415..1518
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1172..1202
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1307..1355
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1531..1545
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1630 AA; 177679 MW; ED6DB6790F21E26A CRC64;
MTSINLHQLM EKVKKVQLFS KQPGKGMVQG DRVGFVCLAS AERGSGASVC RNFGSNSSRV
ELNFSAEQCG KVGGVDVIHV SSPCRHLSPT VICRSAVYAV VECKSRTLAC YASEQDARQA
RKTTSCMPHC NGGKVVPTKA NPTTNAGGIF LLRHFQPSSS RHFLKSSSSS SSSGNLAFTS
TPGSTFATAS TSLTPVCCEE KVFNRFKFHS PTNSGRFRSD FNVVQGRSSP LCIWSGPACD
SFHLHPAVVS MFSVSLFSFC FCRHCLSRAT TAEAEIESQS NGNEKATSRS QSLTILPYHF
KEWSNNNGDL SSKHPIEVDS WSLDRRPALH NNNNNSRTAA IGSGKLTMPQ PLPVMCTPES
RRIPSHPTAT YSASAQLFTS STPTSSSSKL ANFFARPFRN SALKRTKSVS KLDRKRSNFE
VPVKNGALSS TSAWNDLNKV RNSRSHDSLL ISSGGSSSAA ACLLPQTGGS NTNTNTNCCN
TVVDLSNAGC SASSVHSSLL ATPNCFRITT VNSAGVATPK YFSCGTAAER DRWLYSLNHA
MQPNRDQMRR KEKSLQVWIL EAKGVTAKRR YFCELALDSQ LYSRTSSKLN QDICFWGEQF
VVNNLIKLDE VKICLYRESE RKKRKDRNTL VGSVRIPVRE LCSKYAVEKW YVLNGQEKSA
SKGETISLRV KARFQSISIL PLKAYSRLLQ FLTDKYLETC LALEPVLGVK AKEDFATSLI
RIMHSQNLAK HFLCDLIMSE IKTLENDHLM FRGNSLATKA MEAYIKMIGE QYIQRTLASF
VQNVQDSGED CEVDPEKLPA SADIVKHQEA LLTTVHAAWG RILNSFYEFP IELRLVFHEL
RNRLADCGRG ELADNLISSS IFLRFLCPAI LSPSLFNLVQ EYPYGKTARN LTLVAKTVQT
LANFTKFGAK EHYMEFMNRF VEGEWQHMRQ FLRRISSPLC TNFPCKTTEW SGVIDLGKEL
SLLHSYLIEV LPEAVAKKSN WENLNRLCKI VDDVSCAYNM SDISCCSSAS PGSAGSSDYE
NKGESPCVAL SFDSSGDERS KALTDDDLWY NAVDENIGLR RMGLMVQQSR LKQQLSLSKA
NGFELGRSIS TQSTGNNTAL PTTITTTTAA TTTTADGNIS AGQQQKQQLV AGGGDFSFGG
CATAAAACSD DICYVDETTS LLFKSSSNAQ NPITVEPSTV GTSDYNSLSN SPVGSADSSS
GCSEKRLPAA DQASSSATMS NDISLAVANP LYSLQHVPVV WSSSAKTNKL DNSASTSSAA
TASSTTVVTT TSATATTITA AAPASSASDV DRLLRRAPPL RPIDSVDTFH TATNSSTSSS
SSSSSSSTSS STNHHTSSQM ETVSSNNNNN KYPRPRTNPH FAGGHHHSRA MSLSIAAVNA
VPPISCPIAS ASGEQLNQRS GGCQQTAELL LAREVQELRI RLDESQSRLQ QAELRERTWK
QKYEESVPIK WSSDPVQPIL HRLRLVEEEL QQEMNSSAQK QQLIDEQRDR IQALLATNER
LALNLSKLQE KSASAEQMLL LTSLHKRPLD KSVSVNGHEE KKPTSTCGKF APQRANQQQH
RRSWDPCASS SICFNSCSSN SSSSSSSSSS SSSPAATTAD TNNVCCQATD VVNTVITAAA
EFAQLKTTQC
//
