ID A0A0V0VSU1_9BILA Unreviewed; 15036 AA.
AC A0A0V0VSU1;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=Flap endonuclease 1 {ECO:0000256|HAMAP-Rule:MF_03140};
DE Short=FEN-1 {ECO:0000256|HAMAP-Rule:MF_03140};
DE EC=3.1.-.- {ECO:0000256|HAMAP-Rule:MF_03140};
DE AltName: Full=Flap structure-specific endonuclease 1 {ECO:0000256|HAMAP-Rule:MF_03140};
GN Name=sls {ECO:0000313|EMBL:KRX66564.1};
GN ORFNames=T09_10631 {ECO:0000313|EMBL:KRX66564.1};
OS Trichinella sp. T9.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=181606 {ECO:0000313|EMBL:KRX66564.1, ECO:0000313|Proteomes:UP000054681};
RN [1] {ECO:0000313|EMBL:KRX66564.1, ECO:0000313|Proteomes:UP000054681}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS409 {ECO:0000313|EMBL:KRX66564.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Structure-specific nuclease with 5'-flap endonuclease and 5'-
CC 3' exonuclease activities involved in DNA replication and repair.
CC During DNA replication, cleaves the 5'-overhanging flap structure that
CC is generated by displacement synthesis when DNA polymerase encounters
CC the 5'-end of a downstream Okazaki fragment. It enters the flap from
CC the 5'-end and then tracks to cleave the flap base, leaving a nick for
CC ligation. Also involved in the long patch base excision repair (LP-BER)
CC pathway, by cleaving within the apurinic/apyrimidinic (AP) site-
CC terminated flap. Acts as a genome stabilization factor that prevents
CC flaps from equilibrating into structures that lead to duplications and
CC deletions. Also possesses 5'-3' exonuclease activity on nicked or
CC gapped double-stranded DNA, and exhibits RNase H activity. Also
CC involved in replication and repair of rDNA and in repairing
CC mitochondrial DNA. {ECO:0000256|HAMAP-Rule:MF_03140}.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|HAMAP-Rule:MF_03140};
CC Note=Binds 2 magnesium ions per subunit. They probably participate in
CC the reaction catalyzed by the enzyme. May bind an additional third
CC magnesium ion after substrate binding. {ECO:0000256|HAMAP-
CC Rule:MF_03140};
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000256|HAMAP-
CC Rule:MF_03140}. Nucleus, nucleoplasm {ECO:0000256|HAMAP-Rule:MF_03140}.
CC Mitochondrion {ECO:0000256|HAMAP-Rule:MF_03140}. Note=Resides mostly in
CC the nucleoli and relocalizes to the nucleoplasm upon DNA damage.
CC {ECO:0000256|HAMAP-Rule:MF_03140}.
CC -!- SIMILARITY: Belongs to the XPG/RAD2 endonuclease family. FEN1
CC subfamily. {ECO:0000256|HAMAP-Rule:MF_03140}.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr
CC protein kinase family. {ECO:0000256|ARBA:ARBA00006692}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX66564.1}.
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DR EMBL; JYDN01000010; KRX66564.1; -; Genomic_DNA.
DR Proteomes; UP000054681; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008409; F:5'-3' exonuclease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0017108; F:5'-flap endonuclease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:InterPro.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006284; P:base-excision repair; IEA:UniProtKB-UniRule.
DR GO; GO:0043137; P:DNA replication, removal of RNA primer; IEA:UniProtKB-UniRule.
DR CDD; cd00063; FN3; 6.
DR CDD; cd09907; H3TH_FEN1-Euk; 1.
DR CDD; cd00096; Ig; 6.
DR CDD; cd09867; PIN_FEN1; 1.
DR CDD; cd00192; PTKc; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR Gene3D; 3.40.140.10; Cytidine Deaminase, domain 2; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 64.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 2.
DR HAMAP; MF_00614; Fen; 1.
DR InterPro; IPR036279; 5-3_exonuclease_C_sf.
DR InterPro; IPR024969; EIF3F/CSN6-like_C.
DR InterPro; IPR023426; Flap_endonuc.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR008918; HhH2.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR000555; JAMM/MPN+_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR029060; PIN-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR InterPro; IPR006086; XPG-I_dom.
DR InterPro; IPR006084; XPG/Rad2.
DR InterPro; IPR019974; XPG_CS.
DR InterPro; IPR006085; XPG_DNA_repair_N.
DR PANTHER; PTHR47633:SF7; IG-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR47633; IMMUNOGLOBULIN; 1.
DR Pfam; PF00041; fn3; 4.
DR Pfam; PF07679; I-set; 53.
DR Pfam; PF01398; JAB; 1.
DR Pfam; PF13012; MitMem_reg; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF00867; XPG_I; 1.
DR Pfam; PF00752; XPG_N; 1.
DR PRINTS; PR00853; XPGRADSUPER.
DR SMART; SM00060; FN3; 6.
DR SMART; SM00279; HhH2; 1.
DR SMART; SM00409; IG; 55.
DR SMART; SM00408; IGc2; 51.
DR SMART; SM00406; IGv; 8.
DR SMART; SM00232; JAB_MPN; 1.
DR SMART; SM00220; S_TKc; 2.
DR SMART; SM00219; TyrKc; 2.
DR SMART; SM00484; XPGI; 1.
DR SMART; SM00485; XPGN; 1.
DR SUPFAM; SSF47807; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 4.
DR SUPFAM; SSF48726; Immunoglobulin; 59.
DR SUPFAM; SSF88723; PIN domain-like; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 2.
DR PROSITE; PS50853; FN3; 6.
DR PROSITE; PS50835; IG_LIKE; 52.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 2.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 2.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR PROSITE; PS00841; XPG_1; 1.
DR PROSITE; PS00842; XPG_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_03140};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_03140};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705, ECO:0000256|HAMAP-
KW Rule:MF_03140};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759, ECO:0000256|HAMAP-
KW Rule:MF_03140};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839, ECO:0000256|HAMAP-
KW Rule:MF_03140}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_03140};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Kinase {ECO:0000256|ARBA:ARBA00022527};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842, ECO:0000256|HAMAP-Rule:MF_03140};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|HAMAP-
KW Rule:MF_03140}; Mitochondrion {ECO:0000256|HAMAP-Rule:MF_03140};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|HAMAP-Rule:MF_03140};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Nucleus {ECO:0000256|HAMAP-Rule:MF_03140};
KW Phosphoprotein {ECO:0000256|HAMAP-Rule:MF_03140};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000054681};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022527};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 16..86
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 120..210
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 295..383
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 424..513
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 523..614
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 670..761
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 786..876
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 911..1001
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1048..1138
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1181..1271
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1398..1489
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1530..1622
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1663..1754
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1795..1886
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1927..2018
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2059..2149
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2190..2281
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2322..2415
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2455..2546
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2720..2810
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2851..2942
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2983..3074
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3110..3208
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3253..3344
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3390..3481
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3496..3583
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3632..3722
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3753..3840
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4108..4202
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4207..4295
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4306..4394
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4429..4534
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4971..5060
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 7660..7748
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 10426..10521
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 10529..10624
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 10630..10729
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 10735..10832
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 10838..10926
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 10948..11024
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 11029..11122
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 11172..11427
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 11499..11588
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 11605..11694
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 11704..11778
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 11780..11867
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 11878..11967
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 11994..12084
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 12138..12234
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 12233..12323
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 12337..12429
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 12439..12521
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 12655..12744
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 12755..12844
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 13008..13097
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 13110..13201
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 13214..13303
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 13314..13404
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 13418..13512
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 14014..14333
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 3234..3255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3972..3993
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4037..4064
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 15016..15036
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4044..4064
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 11201
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
FT BINDING 14048
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 15036 AA; 1687830 MW; 7291EDAF3F070F93 CRC64;
MEQTFNPLQN KRSVVGQQVI LECQLEGQPD PVIKWLKDGQ NVTNCPDYQI FQEGNKFKLI
IPSVQMADAG RFDCQAINAA GSKSSSCILI VAPPPSPGER QFMTAPSPRP PPTPVGPAAP
YVVKELKHQM LKIGSSARFE CRITAFPAAE ITWLKNGKPI TNTSKYKIDN DPDSGICSLT
IAMMFAEDVG QYSCSARNAH GQAVTSAEIL YKDKYNEWLR EEQIKITQEK KRSMMEELDN
AVQQPRKQKG TFYTPHSQRL LEQLYTEEKV ETDIKINESE ASVENVPFQG VPQPPQVIRP
LQPVSIIEGQ KAELTCQIKG NPTPKVRWMK NGVPVQNSQR LQTSYNGAVA SLIIKITFAE
DAGMYTLVAE NQFGRTNQSA NIQILTQNSV NGVVHRKNNA VEQQKLSRDL AVTPDLLGQG
RQKPIFQQPL CDLQVAENQN VRFDVRISGR PYPNIQWLKN GVLLQHGHRY KLLSSQNDLN
TLIIYMATVE DSGTYTCVAT NESGQAQCSC ELTVKAHSQG SAAHFTEKFN SLIVHPGDSV
ELKCSAVGQP RPTYHWYKDD EELIPGQCPY DIVNMPNGTR LRINNVRLDD SGCFQCNAVN
MYGTAVHKAP VKVQMKSSSQ QITPFPRDST SDQALIASAT PELATIRHRQ RAAGLSNAAW
FVEAASAEPP KIIGLSADHL SLLEGQLAHV EVRFQPENDQ NLKVVWFKDD LPLEQKARLM
FNIEAGRASF DIDYVQLSDG GLYKCLVVNQ KGKAEATFTI SVTELPEVDF NESHNYRENV
SSKVRPNFVH ELKNVESVEG RSVRFEAKLV PTRDPSLQVD WFFNGQPLRL GNRVRMLQEF
GLVSLCISAV SVADAGVYTC RAKNLIGVSE SSATLIVKTY EIGNYKNADN TRGYIADVDI
ADVEEDSCKM PCFEVNLRGG TVKEGGRILL DGKVSPARDP YMRIDWFKDG KPLKLANRIK
MQYDFGFVSL CINPTYHEDS GVYVCKASNR VGVAESSAEI CCAGDDSIEL RTQHADSLQR
IQRIEGQEVH IGPYIEDRPE EVMSIEKPRF TKHLSNAEIS EGQTAHFDGR LLPFNDPKMS
VNWFRNGLPL PNGHRFRLVN DFGYVCLDVL YAYPEDSGIY TVVAQNELGE AASEAELHVI
GHKSIYLESQ HPDGMNRIQK LERQTEIPLH EGIERISEHS PVLKNQLRDL TLREGSNLHL
EVRVEPVNDP TMQVEWFVNG RPLLTGSRSQ MTFDFGYVAL DLKSLIAEDS GEYIVLIRNQ
HGEVTSRCIV AVEAKDSVLT EVQNVESFER IKALETEKPR QIQESESLPQ SAPVFTKVLS
PASITLPEGS SLHLEGEIRP ISDSSMKISW LRNGQPIPIG KQAVIYGTQH PNSYEQILRI
EAPKQNREEV DEEQPDAPYF VKELPNEIAI TEGQSVHLEC IAEPKNDANR SVVWYFNGQP
LKMGHRFQFS HDFGHLVLNV LYAYPEDSGD YMCIIRNQNG EARSVCKLQC QGKKSMVLET
CHPDALRQIE ELERPTPVQE QLDKHCTEKP EFLNTFPEQT EPLLEGQAFH VKSFIRPTDD
PNLTVEWFHN DKPLLASHRF QTKHDINFVS LDILQVYPED SGLYTCRAKN KNGTAENSVF
IACNSRKSVI TEASQPESWE RIRQMEAVLP QTAEEMPVEK VKPSFTVPLG GETDVKEGQS
VHLACQVSPT DDADLKIDWL FNDQPLKMGS RFHTCNDFGF VSLEIDPVFP EDSGVYTCRA
LNEKGEAFTS LKIDCKPIKS VDFDSHHIQS LQKIKELEEA QPDRPPSPEI QYHPPTFTQV
LQNVDTINEG ESVRLECRLQ PAFDPSLKVT WLRNGQSLPL GSRFRPTHDF DYVALEILTV
YPEDSGIYQC KAQSAHGEAI TSCSLKCLPS ESLILETKNE NSWNKIQEIE RPAIVESIAE
TPFITPPSFV EPISGMQTVN EGAPVHFECR VQPSNDPNLS VQWFHNDQPL MNGHRFRTGH
DFGFVTMDIL YSFPEDTGQW TCRVANSLGA EDCHANLVVV PKQSIYSAAC QPKSLAKIQE
IEAVPQKQDA EQELVPVAPS LLQPFENTER FEGQPVHFEC RALPVNDPKM IIEWLHNGLP
IKEGNRFRKT FDFGYVSLDI AYVFPDDSGV YACRARNDLG EAVVQAELTV LSKGSVMMDT
TRPESWHKIQ ELETVAPALA EAEPAAAVQP RFTQELNSCT DMIEGQPAHF EGKIEPRNDS
SLKVQWFHDG KPLPASSRVS FQNDFGLVTL DIAYCFPEDK GIYECRVSNA AGTTKSTCEL
QCKARSAILA DTMHEGSLEK IRIIEAPKDV PPSQDVACNE RPVFTQPLRN IDDVPEGEAA
VFECRLRPVN DPNLHVEWYF NDEPLKISNR IMPTQDFGYI TLKLASTSTF DTGVYLCRAW
NLLGEAVTTA SLQVQGKENI LRDSQHPESY RKVQIIENLE KFPRQEIAEI AYEKPAFEQV
MENLENLNEG MLARLTCRVR PADDPNLKTE WFFNGKPLAH SSRIHLMHEF GYIALEIDPI
HVEDSGVYTC KAFNASGEAV TSASVKVLGS ESLLLQTEHP VSWKKIQNLE AKPLVEVEEQ
ETIQEKPRIV QPLQNFSDVP EGSAVHLEAL YEPAKDNTLV ADWLRNGDLI IASQLVKTKC
ELGHATLDID NAYAEQHSGV YTLRLRNREG EVMTSCSVKV LGKSNVLNDT QHESSWRQIQ
ELEKPKEAEG TPAGISYGSP VFTEHLNNVE VNEGESASFR CQYEPVNDPN LKLEWLLNGK
PLEASSKFSV NSEFGYVLMN IAYVFPEDSG VYTCKAINAA GEVSTSGTLK CFEKANLILE
SQRSGAMAKI VELEAPKSLP TEDDTVPMLA PQFLTPLSDI TDIFEGQAAH FETRVEPAND
PNLVITWYHN DIPVEATSRM KQINDFGFVL FDISSVDMRD NGQWTCVAKN KVGQAQCSAN
IQCSPKAGII IDSQQPQSLP RILELEAVKA TPEVLPAVPP EAPKFITCFP KLDPLTEGDT
VHLEAQLVPV EDATMKVEWF HDNKPLLLGH RLKTIYDFGF CVLDIICITA EDSGEYKCVA
TNASGSDCIS TTVTCQAKGS LLLDPISQTK AQAVKDLEDS LQRIPEKDVP EVLSMAPVFT
HPLQNQSQLV DGDSVHLEAQ LIPVNDPDMK VEWFLNGNPL KHGSRVKCLN DFGFVILEIA
PVYAEDSGEY HCKATNSQGE AVTSATLVCQ PRERIIREMQ LPKELASAQK KIEELEAPKQ
KLDTTEEPSY PAPTITPLTE TELEVNEGQV AHYEFKLEPL DDPKMTVEWL YNGKPLSHGS
RLKALYDFGF VVLELAPAEP HDSGEYTCRA VNAAGEASAK VSLNVKMNRG VSYDWMLSQA
DARNKITQLE DYLHRPPEEA SLLEQDFGQP VFVQELSDLG DINEGEAVQI DCRIQPVGDP
TMRIEWWHNG HLIPYSSRIQ THHNFGYVAL LIQHAIPEDT GEYICKAINS KGESSSKCIL
TCRSSTSFPP PKFVSPLLAI ISDVNEGDSV HMECRVIPIN DPQLEIQWLF NGKPLSTAHR
FKTLSDFGFV SLEILYANPE DTGTYTCRAW NKAGEDSTAC TVSVKKRPSL IFERQAPPVS
SLDIARRISQ YTTKPCVLSA ENFYQDRKCQ KPQFVSQLEN TAVNEGDFAK LECQLTPIND
PNIRIEWYKN NAPVILGQRF MSISDFGYVA LVLLYALPVD TGEYTCVATN KFGSDKSVAT
IACAPQKRVI TDSQMPQGKA DSTDAQNRVN QAPAFTIAPT HIQAVEGQPA RFSCAVTGMP
QPKVSWFVND KQAVNGSNYK LGYDGMHYLT ILKVRPQHAG EVHCVAKNSE GEVRTTTTLD
VFRVQDFRSH SLKPAKREDD MDIARREEQW KQESLGKLKD AFEKAPKADL QKLMRIETDK
QQPSPLESKE LIDKFKKKKQ DDFYDKIYLT EQSKVVPPSQ FTETVTLRAT PMLEKELPKE
QKIEYKLRPA PRTKATSDMQ TQPAWHRSSR RHLTDEEENA LYHRLPEQQK EPEIFARDLV
TLKSVKPNIA METADESHMQ LEEHKLASTP SNKSQQTWTT NQDIPSQQVT LKPSFVPRAV
ASQESGTFDV ESRKDAAAML KRPSKQPPSI IRPLQPCQVE AGRRVELSCE FAGSKPLTIV
WLKDGKRISS SFEFQTLETE NTSKLVISKA KHNHAGEYTV VIKNVAGEVK SSAGIVVGEK
ISKGFSPKFI QEIADASVIQ GATIRFDARL AGKPIPQVVW LKDDKQIIDD AHFVITADQD
LYSLIITEAF PQDAGMYECV ARNVHGEAKC HATLTVTKPT AFKPSPQVAK NVQSASLPQL
VVNKGDVATL KIPVSAEQGL SVKWYKDNKL ISPDNRISTM CKDGIVSLII KNSDIHDSGN
YKAEITSSKG TSVAVFTMLC KDSHTFYRWA SHSFPRKTPK PMPLGFTSPH SSDRISAAES
ISYDDIGSAL YFETELKDIT SEAGTPVTFA CKLVGDAERI VWRKDGQIME EGDEFVQQYN
SHNGWCKLTI SEVFPEDQGI ISCQAINKSN ESVTSCFFTV QDFKSNTKSK SAPVFPSLEM
LPPCITKHLE TITTPPNTTV CLFVEFHSTA AADVQWFYEQ KALPNSPKCI QRRGTNWAQL
QLISPREGCY SVKVTNDFGT ATSIAYITVQ EQWKSLEHST ESINISEMID VEAYSSETYE
KGIASMHGPY FVPKLPDKLA ILNRKLHLTA TVDATPEANF AWYFENIELK CSTSCYITSW
KNQSTIVLEN AKHGTYKVVA SNALGSCEST VAVYEDESES NRMSKFSPQF IKKLHNMSVE
AGEELKLVVE VLSEPVASFK WFMDNNNVSP STVMSADNIS ELRLIPEEGK THTFVVKAEN
EVGVAVNSGV VIVKPCRISK RISDDISWHS NDVYFEETEM MHLEMSGNFP YQATHKEYLD
GEMDLPYPLA STKSTEKVIS DQKQSEYLHH EHTLMAEALF TAQPSHTDLA PKIILPLENK
TASSTENITL SCKIYSAVAY AILWYHENHR LIDSEETQIV VKDDGSQLII LKRPSEADAG
LYTCLAVNNY GTASTSSRLT IMKPALPFTY QQEMRDLYST STEAIEICQE TDVVQQKKVT
IESTMPQLQS SGALRAVSQT EFTANANLSA NDFEVSTVIQ HSSKEYASAD ISQSVMKKTN
EEMEYRAEIT KPPYDDTLNL YSMSAASTKP SFTDVPVFGM ERTIHMEIFE EIKITESRQK
ATHQTETVNI EFEFCTSPSE EVYISLDAEC FSCGSRILLK GSMPECKEIT FEQRNIEEMT
ILYEETTSIR YYSSTVTSHE EELSSASDLY IDKLAGPLSL YSEESIDRNF SFKLIVVSEC
AHTVPLCREL SFVVAVSYAE HEWNTVVRII QEETHQYEEE CLTSYFTAAT KPALMPQVDY
VSPVIATKAI QLEVTDAKEI HEKILSDHSI TLHMDVCLEA VNNASAYTLL TTSDRFVCTA
TIHTEGEQKA EEITKTVSEI THEEVLCVIE TQIRSEISES EQTIYLEILC PSSVHYCNLL
VKCGEILQTM ANVYLESKTV TLLIDNISKV REECNEQYNA PELVLERLPQ QQLIQRAASS
TEAAVHKSIN ACRMTEKFTT ITLEKKNSEE IEEVLKISTK PLEEVHVHKM VNSFQLAVDK
EEHLEETCSF QVPRRILQTV EIIEDECLEE ITVHQQRTVS TMLDMLVQLE IPSQQFLCDI
EVQLSLTASC EANILKGKEE TVKTEQSIKW VVEECAQESF VEIVLEEAKH IELRVTEQHM
DIQINCHDIN NSVAVLLMFF EWCEATFNVQ EVLPLSKVYE QRETLTTSST SVESILISKQ
TKYEYVETTI TGDVLLHRPS DYFELIVCID GVNVEAIFCK ASLVENAINF QQVALQRREC
FDVLPLPVKT VTEQSVKVAE IQEIEKVVCE FEHIVFDSFQ TTVDHSMEAN LIVDISKPSC
AFHSSIIVML CDSSHATLSV INRQEESTSS ITTPYNESMF EANLRLIIST DDSISSTTSE
MEQGIISSME VSSIAEEAVV LSDSSVHKME ATHIVSDESK TVAIDFHNPV SAAFSTACIE
EISIFSVEET NVVCQDWQCS YKFACPSKVS KTLVIVESDM CDSAKFTTAD KTVEFSYMEL
TDICDLAITI LNGMEFSSPM MVLRKSATDK TALFHHLTQS SEIKVLIDVE ANNSTKLLTA
FEFDTIASEL QNRSSWSTVC IIENYENAES FLAVEMARIK KQSIHEVSEE ISVVIEQPHC
EEKACEITFE SKRLSSASFN FKWKDDLLYD VTLKNHLTLS EAIACVISCM DIEAAKIYFY
EVISTKMLLN NSTAENSVIT LQYCHPLTQL LKTHLTHADI SSLNEVLPIL KTEITAPEMV
KEDVESNLLC STTAVTELID VTEVSASVHT RAADAEVSKD TPTVTLKETY SENQQDSDVT
VELLCSSKSC SAEAIICPYV WESCVKRQDL HSINFTTVAN LKSESLRTEC LISPFLNETT
SVSVRIQTGR LNQSSVTVNL SKENMKDHVH AVVTSLDFQQ LKPFKACCPQ KHLTSVDFYA
SKKFEMYNTL ATTIIPETCL LDYNTTLIVT KKNEIVTEET MTESTVNSFE LPDLRNAAET
QFTSLEHTAI DTFLEKMPFY GECGATIECS DTQSGVMQHG SHVCVVEREF ECKDTPMLTA
CLIEADSDKC YTQYLHDSFK KSFYDFLLKH VESKEECEVV LQMDTCLEEE GILYGNVVEN
VSVDSFFQTV AKPHSTTELR DLHAVSSCIS RFKSEESPVV THQWIQAFST EAMCTVEESV
SDIISANVTL RTKDVGYAEC STECEFRSAV EMEQTFGCIE NAENACLSMV YDIKKMLPAS
HYVSHDISIR PELQLQEVNV QEITEQAEFA HKKLLDASEV IQIVPSGTIL QYVVDCAYEE
NSISFQASNI ISECEMAKCL EANQQSVITF VFSCDTSNIT THYRTSSVTD TTEAAIPEYS
HETWKFASAD VCSFEKYISL SPCSSAFAEY TRAGQAYINI LSAWESASIT ENITMESLSK
CDGCQHVISH LLKETYGSCH NVLSKAFINT SSASDESQLI INFLKQTADA KDFKIQYEEC
SIRTDYLGES SAVIECTVQE VQQESVFKLL KLSSMLNEKH LDLTLESDQH FRSCQCTVHS
LVMETASLAI TLEETCADFG VSPSVADELI TKSHSTHPFS ISEKQEKFTV VATDIYLDSS
VNSSSVEYTT TALQRMSDAT VHEIVNVSND FPCKRENTFD EDKILHKYVL QETIFQSAEK
TDLSVSMEKT EESEQCTFTR WSSVVACTVP IYYSVSKMAE EIPIPALPSM KETTVEVLLE
KPLSVLECHF NFTDFPSVIS YLGLNRQLIT CFNVKPEAFE KISTSWADVD LLAQDMFLTD
NSKEETYSIE NKQRSESEIH YSTDEEKCLQ ASYEEVYNNV TLERTSVEAV EIPMKSEEII
KCSSEHVYCE ITFVLKEDNK STESYMSSCN FESESAFISL IEEDLTCTAK ACNLAENQNI
LTSELLEKFE NHVTTNYIDE VAQFQHDDEL QDAVTLDAKD NVIAGLQLTT TQKFENVMLE
VSWLHQLEFG DLQSIIEQPD RIVTDIHIQP ISPKRTQEVL EVIETTDEEK FQSISCSSNF
TQENEFKNEI VCSEANKEHA MLYLHLIDTP ARQDVFGQAP EFTLHLCNTE IAEGSHVRLK
CIVSGQPTPD IQWFVDGDQL ASSEDFNIIY EDGVSMLNIK EVFPEDEGEY SCEAVNQFGT
ARTAAYLAVI PVEKQASATD KECTECYGKE FANDEWPVET VTMSQECLSM LKPEASCEAD
VAVRITDLEQ LKCLSPISDG IAEIVASHLA ETNEVFVYGS TKCMEDTPFT YISEKAVESV
AEHTLNMREN FAEVNTLVSL SLDANQNISL QAVLKQPRVA SLVFCLTSLT KPILPTLVND
QETARKYGLT LHSISDDSIA LNVRNSESFA DSSDFESSSQ DAFVSIDVDL VHMGARCCGI
FTLLSRPTES SCLTLTECEL KELKVLQSLL TLPLSREDCF PLIERYIREC KGYISMEATL
VRRDSELNIS ACEIHLYRQF QNVRLSLVTV HKHLEQTDNK ADLSEEFPCN EVARNFLDTQ
YNHATCEMKL FNLNSEAFVD FNSVNANAEF KDTESMLVSL DFEQIQSQPH VLAFCIDNQM
LSLSKNFVSR KGCYSDVDIQ NIGGDLETFT NIPHSSADYS CLDEISCSIL IEKASESISC
SNTYASADML NISKCSLFIP FLKVDDSVVG VDVQISKDCK RTGDDIMSLP ETETNQLPCE
VAVAMIISEK IAKHVSSTAA FLSEPSFFHE MRTASLYPVT VSTTFISENV NNCETEKVFY
SPSITRPGTF TVLSNTISAK YEDIEVLKLD EQHEIQTELY DMDLSTSRTN MCLCQRNALI
RKCNAENKCV CHLPSVCSFD ENFFHVEFKA EMIANNCVEM CLAQFLVEKC QLKLLENRQS
TICEVDCLED SEYLHAVLQY FNFESISFQL SHTVKNTLNK KFSRDVITGH CSTTLPVKHT
ENYDIALTVL SFNANALSCC EVHENITVQK SESSNSLSVS PDSILSKFTA VSDYSNVEQC
LTVQNNLEND ISFHSEFSQI ESELVVASNP HDSYTCILTV APFYNCEMWR SVLVCSCCYD
ALVETDEEAN ITFSYNKTTI ECCTSISFAN SYVEIYCPED VADIRVKLGC TAQQPYQQSL
NESQCSLTVL IEKDESESRE FIDFPEKVHS VTNRSFFARQ TFLEETVDVQ FRSSANNCFA
DHTYHEAGDK SKCTVIKVEN KADEDFQLFA QGIKQDFKAE TVEHIKQYFV PHGSDTKLME
KLSSSENLVQ WFINGSPLVI TSRHIVHTEN GCCELFISNV TFEDSAIYSI ETDAGYIRPV
AELIVEDSTS PDLDNAVIIT EKPFQCVQQN LDAELHGPEQ NANTDINLSE DQHFYASKTY
EIDMLENIMN LTATFTSEIV NDIAKAEKIT DVKRQEIVAH TDLTADMALN LMRAEEIELS
IAESSNPENA CLEVLNLFVA RQHSDETMLA TNTLNLKTPE QSAALCCSEE ENITSLSTTN
MNFLFTLGPL SCSKIAFNSE MKKMLHCANI ILSNVHMFAS YDATENLTAE CCIAESDTCD
TQFSSVDCGK MLLTSTLDQK DDISYTACVH QRLKEETSST QSNFVDCNLI HEKSADHKEA
VASFSEQCSD TISSSVTAAT ITKKIVSIDD IPIIAVGSEI MESLRKPKRK EKRKISEITA
NESFNWKNDL KVERICMEIS VENCSSSVKA ESVQALIEAD HKEETESICC LHQPHFFVES
AFLLSQKQQS QEKQTLNILF SANFAVSESK ILLQELCTAS EEAYISIKEH YDVHLTCKQT
EETVSSTLSR TVTADEVDFK NKKEVIEESA IIEEPTKSSC TAFDVHESLH DSGDASFHFT
LKYHQSAHIR RASDFSELTY TINLPNLERK QYEEIQFQDV NYLKSPEQLF KETITTEEQV
ENAILEHSVD DVALKVESQS ISAKEGASAE IEIKDFYKGT TVMNITATVM KKPISEEVTK
ILEINQMAEN SYSCGQLAES VTNETRVKIT CKKPQEIMAV QALFAEVTTL FSYEFHVGQR
ICKPLQETSR LLSAVDTTQR YFQEISAEVE CRATDDNTSS TERGIDLSVH SMTSSAVSKT
FADIEVVLEQ FPALEITYNL ENIRETLLLN VCDQYFKLEL PLKQLDAFMS ILLPYTLKIT
RQSAECILGS AINFVEADVR KKSECSHCMK ECSCAPFSGC AICISRANVS LSVILDKPST
SQSEAMIPIE QKHKLEYLDF TYASEFTAPI QSEDEAHFIS TAKTSQQLQH IKSTENVVNV
NANINGLEAN AEVYHSVRAD EMEFTSEGFF SLKSKDQVDA EEASSLSTLE VYENFKREDD
HSDITFQKLI IHEIPPLDET LSFSVVAEEC CLKHADLSEC CQAVIAENKV CLSHFQFKHV
KDHIHSCSCD IYFSKKSEVA PCTVQLGKLL LQCTMSESSC FLHIPNGSSL AAETELLDAQ
AVKIPALEIL HTECVCDKVS SWKGNIELPV KEKICVSDFL LKDYINSDFD ITVRIDSSHA
SYTIKNTCIV ASDMEKITVS SICTCFERGS IEEMTEEIFA ESLLGIRKYR HRHLKDFTEA
ACYCIALTKH QESLSCISSY FTSVRESCFA DIKHLKLVEN YLTKLKPTTE EATEYDYVNI
STAEKVDVST IMASSTFLEK ETSALCDMTF EKKADISSSN EFVIHTKSTA DAVFSVEDNA
FYHVSAELSL SHKIEMDEIY EQEDASYCTC SIDASLEKLS SKDYAYAFVD LSNYGKRVFT
FKHFRDIIEA SSVSSSLQRH PPEKPELFVE NLFATSSDVI YTSEKVNFQL LLEAKTSITT
IFTRQLLNDV CSITLPQMNQ FEGIVCDISE HPLELVTSVK IAPVIPTAHL TVTRLSDHSV
NLEWNYSSET TEDNIDGYDV LLKGETDDEW SVVAILDRSQ THCILEDLTN SYTYKFAIRI
RKEDAQSELL ETESEVYVQS RAVSLPKRPK GPLKVNVKTM SSIYVEWNPA EAEDFMNISS
YVVLIRESQR TTWLEVATVG PEETRCHVSD LNSGSEYHVR VIAVNSLGIS EPLETEHPIL
MERIPTLLTP PSPCKPPLNV LSVHNTSVTL QWNPPEDDGG SPITGYVISR RHLAQKHWEE
VERLPEFVLE YTVSNLKQNA RYLFRVNAVN SIGISEGTQT TEPVNIRKWK DKPGAPGKPT
VKELNADFIV LQWSPPEAAN NATVTNYIVE RRDEGCVRKN WLVVSRGINP NAELLVERLI
PGNTYTFRVS AENDSGIGPA SEISDNITLP LKTVGIAPNF LTLLEDTSVF ENEDITFNIQ
FCGQPAPRIK WYKNGREICS DEKHRISTAK NHSSFQLLKA SENDEGEIAI EAENCHGTVT
QSAQLKLKAV AKIIRNEITQ NELFRGIGET AHVSFEVKGS PLPTVTWEKD HQQLTVSNRV
SVQSDGPSQS LEISQCTYED SGIYTLRAAN IYGEDSIDVK IKITGAPSSP GKPVVLECDE
ESITISWTPP LYNGEAEITL YYVESLRVGN DWTVFGTTKQ EKLTASFTVE ETPVKFRVKA
ENVHGISEPS EATIWTRMLK QTEDITVDLT FQQYKEKQQR QMSEFDSLVL SVPPTSLHKT
DDQLPGNFYD KYTLCEELGR GAYGVVYRAI ENATGLTFAA KIIQTRPGIP KDNVLHEIDI
MSQLNHPSLL TLHEAFDMNS EMILVLEFVS GGELFDQLLE GKENLPEKEV REYIRQILHG
IEHMHQKQIV HLDLKPENIL LSTSFSKDIK IIDFGLASKL KKNKSVQLLF GTPEFCAPEV
VNHQSASFCT DMWSVGVIAY CMLSGISPFA GDTDEETLAN VSVADWNFDD SIWTQVSDTA
KDFVSKLMTK NKNNRMTVEE ALQHPWITEE PAEVTEIAAP VERPVPQLKL KKDSITKRRW
SDELLPIGKL AKHSAILRQA SMDGVFEREL HLEVPDKIPN IIAKLENTVA EAGDLVVKLK
CTVDGSPQPN ISWFKNGVEI TTSKKYKIIH DNTNAELNIS NISEDDEAVY SCIAENKFGY
AETAARLAVK KVDKEDSLKR SDSVPTFFSC PYDQNVMVGE SFDLLVHVGG KPFPQLKWYK
NGKQINDTSE KYQIQRFDDK ECITIQSFQK DDAGLWQCIA INDLGTCEVK FRLTLKYPEE
FCPPKIIENL KDISVENGQS FQLQLLIEAN PLPEIKWYKN NTEIHHGEHY KMYFDDKNST
YALSVNPAYV EDSGIFKCSP PSFRIPLEDR TAVEGEDHTF VCLVDSIPQA EITWLKDNEP
IGTVTNQKVE NGICSLVLRN INQNDAGVFS CVASNVYGTC RTDCNFSVHS EVENAHYPEF
LQILTDVTVE ENSQIALECL VEGIPFPKIT WYKNDCEIEM TNRMMYTEDI SGHCALRILN
ANEKDAGIYL CRAKNTAGET TTQCVVTVVD VKCKRSINIP DESELESEKR IVEPLHIVQP
LQDVFATAGK SILMECEISS SPRASVQWFK NGQFITENAN MRLVFDGRKA TLRIIEASID
EHQGEYICRA TALDSVVETR GSVIFKDEGE VQHSDLRFTS IPEQAAPIVY SEVEDIQNVL
KRPVADDVEL TWSDKETLID SFYITEVEKT SLTLCWSEKG QHHEAALYKI FVRPQHASKW
TEVGITKDSA FHVINLQEDT EYEFLLTAKR QKEWEKPVQL SVPADKSKIR TLPKLHCLSD
LNVKLNVGEK LKIVCQVDGN VTSVITCYKG NTKIQDDDRI IVQHQNDGTI LLMIESVQEN
DCGSYTIYAE NEYGFSYQTV TVTVTSANAI SEQRETPNIP CILHPLVNQT LRTGKTATLT
CRVRCIPPGK IRWYKNGQKI KSGNRYQLLA SKHQAYRLMI HNVDEEDTGL YQMAVENEYG
RASTECMLTV KGGVQHKAPF VEKSLEDVRT NVGSKVILKC KITGQPNPSI IWLKDGQKLK
SSRDIQLNFD DNNCMLIIHS ATVENTGLYA CSATNLVGTV STECRLLVEG PPDNILSKYK
APVFTLTPEL RLAALENENI HLQFETYSDL PVRFTCLKNK LPADAGRLNT QIYEGTHMSW
TINNAMISDS GEYTCIAEND VGSSEFTFKI WITNLSQCSD EEMQELKEKK TPRAPYFTQN
LVDVQSQTGD DVALKCCFDG YPTPTITWQF GDNTTLKYNY ECQILQQGHE CKLHFPSVQQ
KHSGIYRCIL ENELGKAESE CFLSVGSSSL YPIPPQFIRC LYDIWTPLDN EITLTCQTIG
IPNPDITWYF NGQQLLESSN VRLFFDANNV CGLTIVRVSG PDLGQYVCEA RNEYGIAKTA
ATIHAGEPHT GKPPIFLKGL QDQTVHAGSR ITMGVLVKGE HAYKLSKKYE ETVIITGFPD
GVLSLDVPTE QTEGEDLFAE RSMKTRRKIP KRLTLKEYQG EAPEFIKGLK DVELEEGSRA
AVSGRTCKRK LPKTQDEQSP SLCTSSKVKT VEDIRAIVHR RNECPCEPKF IIRPRERKEI
EEGKSLRLKA ALSASPTAQV SWNKDGVMLE SGSKYGIYND GDFYYIEVHR VNADDSGFYN
CIASNTHGVA SASSHVVILP GSPEKAVRPP TFTEVLPGVV DASVGECVSV ECSFEGKPIP
HVTWTKNGNT LTPSSRVQLT YDGESASLTV NKVEYSDAGR YCCKAVNCAG EARSTTKIKV
KSASELDATV APMPKFLHHL VDQTVGDGDQ VTFTLQLVDA WEPIKITWFH DKCEIQDSPA
FSYVRDGDKC ILIIQDAFPE DSGVYMCRAE NAYGQAISAC TLTVIGKEQD PEIPSFTEIP
DTATALIGQS VTISVNLKGY PEPVVSWSKN NAALSSGEKY QIYNVGNSHH MTVLNCGWED
AGTYKILATN NVGSCEGTVL MDVSKDFTTA LEPGHSHPLI TVAPSGAEVA IGDPLQLNCS
FTGQPCPVVV WYFNGKRVEP SDLVSVIHTE NASFLTVKSC QEEHFGEVSV SIRNQYGEDL
ASAHIKHRKP VSHRVWLIHC AYRLLSVMLL LVCVVFHIPY FHIQAYDQAQ KEQQACERNC
EIHDTLKAYE NCLRRCYSYV DYNLVPTRFT GSTSNKTYPK PPTNITVNFN VYRENHSKHL
RATINWDAER ENIVSRSENC NYLLDDSRTG YYLIFTAKSN SCEQKFPGYY TQNIPANARS
WDLPTQTMSL YPLVLDFGCK YRVEMRSEPY PYGDTNYASI VTVQIPACVD NYCSCPQARV
SQPEILTLRP FWDPESNSIK AQLVWRFKWP KEIKDESIEF RVRLAQVIRR AGVAALSTFR
FLTIVGEPGK QLFEVILGNL KNQSEYQVQV FAINKHVCKS KEEIAEFTVN VNSSKNNTDE
PAVLENNESL LLPLTTNTTS SPDETETSVI VLSTTEKADI DKNTTTNVAS DNGNILQTFE
QQQQQERYLT ATLPTLAVIV LVLISVYCQM RFRRAVKSAE TKEKFLRIPD KSSFDIDRYL
ELSMETNILY TEKEISDAQR RGAADRFEMS YERLTFKGVI GQGAFGLVYA GTAESIINHP
GPLVVAIKQL KADATETERN EFSLEIATMK LIGDHPNVVQ MFGCVTLQQP NCMIMEYVPY
GDLLQYLKNV RKQYEKQLST MASTGCQASA INLHTVDINV VADCHCGYCL PAVENDDTEL
EYRQNSNESN IPNLSYSLNP VELQNFAMQV ANGMAHLESL NITHRDLAAR NVLVGYGKCL
KISDFGLSRS GVYVKTTSGR VPLRWLSIEA MRDHMYSSKS DVWAYGVVLW EICTLGGFPY
RHVADKELLR YLDSNHRLEK PHSCTDSIYK LMLLCWSKEP ENRPPFSQIQ KMLTEMTRNN
MIEALLYDLE YTMSDEESEE SVTVDEEEER KPIVVRKHEK VDLPITKITK SPRVVGILLG
TVSGKTVDVT NCFAVPFEQD YTALPPVWFL DHEYLESMHM MFGKVNAREK IVGWYHSGPH
LYSTDIAINS VLKSFVMHPV LCVVSVKKHG IPADAYIEVE EVQDDGSVPL RTFELLSCCI
QSEEAEAVGV EHLLRDIKDQ SAGTLAQMTT RRVVGLRGFV EMLRCIKCYL EEVSGGSMPV
NNNILYHLQE IFYILPSLQA SLSESYLSET TDELMGLFLG SLSRAVYGLH NLIDNLVKYR
EAEKEWDKKE YTKRCEMARQ LKKQSTNEPA QNKVIADFSP DAITERTMNS FFGRTIAIDA
SMSLYQFLIA IRQDGSQLST ESGETTSHLI GMFYRTIRMV ENGIKPVYVF DGKPPVLKSD
ELDKRTERRT EAEEKYADAV QAGDSEAINK FSRRLTKVSK EHVDECKRLL ELMGIPYIEA
PCEAEAQCAA LVKAKKVFAA ATEDMDTLTF GSDIMLRYLT FSEAKKMPIK EFRFDDVLHG
LNMTHEEFVD FCILLGCDYC PTIKGVGPKK AYDLIKQYRN LETIVEKLDK KKYPIPENWQ
YKAVRKLFLE PEVIDCNTIE LTWKDPDEQG LITFLVNEKN FGHNRVVNGC AKLLSARRSS
TQGRIDSFFT VLVTKKKRPA DEGSSKATAK KGKGKK
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