ID   A0A0V0VT03_9BILA        Unreviewed;       801 AA.
AC   A0A0V0VT03;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   SubName: Full=TWiK family of potassium channels protein 7 {ECO:0000313|EMBL:KRX66633.1};
GN   Name=twk-7 {ECO:0000313|EMBL:KRX66633.1};
GN   ORFNames=T09_6677 {ECO:0000313|EMBL:KRX66633.1};
OS   Trichinella sp. T9.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichinellida; Trichinellidae; Trichinella.
OX   NCBI_TaxID=181606 {ECO:0000313|EMBL:KRX66633.1, ECO:0000313|Proteomes:UP000054681};
RN   [1] {ECO:0000313|EMBL:KRX66633.1, ECO:0000313|Proteomes:UP000054681}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISS409 {ECO:0000313|EMBL:KRX66633.1};
RA   Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT   "Evolution of Trichinella species and genotypes.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the two pore domain potassium channel (TC
CC       1.A.1.8) family. {ECO:0000256|ARBA:ARBA00006666,
CC       ECO:0000256|RuleBase:RU003857}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KRX66633.1}.
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DR   EMBL; JYDN01000010; KRX66633.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0V0VT03; -.
DR   STRING; 181606.A0A0V0VT03; -.
DR   Proteomes; UP000054681; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005267; F:potassium channel activity; IEA:InterPro.
DR   Gene3D; 1.10.287.70; -; 1.
DR   InterPro; IPR003280; 2pore_dom_K_chnl.
DR   InterPro; IPR013099; K_chnl_dom.
DR   PANTHER; PTHR11003; POTASSIUM CHANNEL, SUBFAMILY K; 1.
DR   PANTHER; PTHR11003:SF110; TWIK FAMILY OF POTASSIUM CHANNELS; 1.
DR   Pfam; PF07885; Ion_trans_2; 2.
DR   PRINTS; PR01333; 2POREKCHANEL.
DR   SUPFAM; SSF81324; Voltage-gated potassium channels; 2.
PE   3: Inferred from homology;
KW   Ion channel {ECO:0000256|RuleBase:RU003857, ECO:0000313|EMBL:KRX66633.1};
KW   Ion transport {ECO:0000256|RuleBase:RU003857};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054681};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU003857};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003857}.
FT   TRANSMEM        27..50
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        111..130
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        142..163
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        221..241
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        253..269
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        275..297
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          109..167
FT                   /note="Potassium channel"
FT                   /evidence="ECO:0000259|Pfam:PF07885"
FT   DOMAIN          229..300
FT                   /note="Potassium channel"
FT                   /evidence="ECO:0000259|Pfam:PF07885"
FT   REGION          566..595
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   801 AA;  90371 MW;  589C1F7A17ED67E8 CRC64;
     MPSEADPRWP SEVLSIRKFV HYFKLSLPHV ALVVVCMVYA ILGALVFYYI EAQNERFVKS
     DKIQRIVDST PSKRLHDLKV VLCEAFETDF VTVDMIDYSS SGDTNEISNS VWTIQSSVFF
     AITTMVTIGY GNVVPMTAEG RLLCIIFALF GCPLAIITIG NLGKFLSETV VFLYNKIQRG
     KMLLMKNIAI RFPLLKGLNN YDNFETTSLT YEDIVVDDTG ISAFFVLSIF VFYNAAGALL
     FTSMERWSFM DSLYFCFISI STVGFGDFVP KNDPWYIILY CYTALGIAIT TMCIDLVGTR
     YITKIHYFGR RLKGADLIRY LRHKRIKEEK QLLALKTTEC IESYLKSINQ IKGPTEVLPE
     QISYYDETKF EESVPFLNRP ANVLHFPLDN EPLLSEEIEQ IEVQHFSLVK STNLPNMGTY
     FLSSFWSSSV ETSHQSVSSS NNEKVEMSTF PLSDTVSLLE SARNKLSLFV RNERPSSVKS
     VQLYCSDQPK DVGVRRAYST EMPLLFNEAN SLPEDLLFSK IEPSNNEHAD IQSQPDTGNS
     ELSDSVKGFL MTQSNEILSP TETENFDLSE ISSSSPNISE SSPVSSLTSS PTQSIEVENA
     SQGKFVFPQV NDPDEWPDKL THDLCFVLDG GKLQTSLLTK KDPNWTCHVH PAKFYHSANM
     KIFERVNAVI SGGKVVAAYP TSKSRKSFAA SSKFIPSLVL DKSATVKSTD SRLSIAKSAK
     RAESLSPKDV YKTTRVYSFW KRCPSFHRIC TIIQPNDPGA KIRSHIYVQY IWRDAKEKDK
     QAVIGEIKRQ KLSLMPSFIS T
//