ID A0A0V0W113_9BILA Unreviewed; 1998 AA.
AC A0A0V0W113;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Notchless-like protein 1 {ECO:0000313|EMBL:KRX69455.1};
GN Name=NLE1 {ECO:0000313|EMBL:KRX69455.1};
GN ORFNames=T06_7237 {ECO:0000313|EMBL:KRX69455.1};
OS Trichinella sp. T6.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=92179 {ECO:0000313|EMBL:KRX69455.1, ECO:0000313|Proteomes:UP000054673};
RN [1] {ECO:0000313|EMBL:KRX69455.1, ECO:0000313|Proteomes:UP000054673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS34 {ECO:0000313|EMBL:KRX69455.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX69455.1}.
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DR EMBL; JYDK01000356; KRX69455.1; -; Genomic_DNA.
DR Proteomes; UP000054673; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.20.110.10; Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain; 2.
DR Gene3D; 2.130.10.30; Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II; 2.
DR Gene3D; 1.20.1050.80; VPS9 domain; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR001632; Gprotein_B.
DR InterPro; IPR003409; MORN.
DR InterPro; IPR012972; NLE.
DR InterPro; IPR009091; RCC1/BLIP-II.
DR InterPro; IPR000408; Reg_chr_condens.
DR InterPro; IPR003123; VPS9.
DR InterPro; IPR037191; VPS9_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR46089; ALSIN HOMOLOG; 1.
DR PANTHER; PTHR46089:SF2; ALSIN HOMOLOG; 1.
DR Pfam; PF02493; MORN; 5.
DR Pfam; PF08154; NLE; 1.
DR Pfam; PF00415; RCC1; 2.
DR Pfam; PF02204; VPS9; 1.
DR Pfam; PF00400; WD40; 7.
DR PRINTS; PR00319; GPROTEINB.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00698; MORN; 5.
DR SMART; SM00320; WD40; 8.
DR SUPFAM; SSF82185; Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain; 2.
DR SUPFAM; SSF50985; RCC1/BLIP-II; 2.
DR SUPFAM; SSF109993; VPS9 domain; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00626; RCC1_2; 1.
DR PROSITE; PS50012; RCC1_3; 4.
DR PROSITE; PS51205; VPS9; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 3.
DR PROSITE; PS50082; WD_REPEATS_2; 7.
DR PROSITE; PS50294; WD_REPEATS_REGION; 7.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000054673};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 113..185
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 186..236
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 421..472
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 473..524
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT DOMAIN 1359..1511
FT /note="VPS9"
FT /evidence="ECO:0000259|PROSITE:PS51205"
FT REPEAT 1601..1636
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1664..1705
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1707..1753
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1754..1794
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1881..1922
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1923..1964
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1965..1998
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 280..300
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 282..297
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1998 AA; 225778 MW; 394B3F05C650CE28 CRC64;
MKLNVHITIY YFVMKTCLWT RRRGHSLTCL NIDIPYQPDQ LTVYCRDCCA KEANVVFVKD
GIISEATLNV LVDEEGTVFE KRREPLQNVI LSGLRVQSIT FAYETFGAIT SSGNIYMWGR
SNYGQCGIIA ENVVKPEMSV NHVIVEVEIY AVDDYCMHGE RREPYDIQIV QLSIGGSEVL
AVDRNGALWA WGAAFQNGDS TAWQPICLPY RVPGLLGRRV LSVASGRTHH VALVEYIAGV
DELHGLDEYA FLGNSSNCFQ SNLPFVESCE HCQRGRRSVL TDGESTKSSS TDEPSSSPVG
RCPLGVKLSF ADDAECFLEP RPECKPRSKP QARQRKLYSD AHCRGDEVEL YELPRSKQQH
QASSSRLSFI SFDLIMPSSS SSSSLSEQTI ALDDSNALVG CVSGQSIIPG SSNLTGNICL
AELWTWGGNE FGQLGLNDFE PRCEPTRISG SSAFGIVKIA AGAEHSIAMS SSGEVFVWGS
NENRQIKVAD QRRVAVPMLF KAGSCAKVID IAAGEKFSAF LINGIDYRPE CYICGYDRSD
KDGTPVLRLY FPETCWPASL MCSDDYIICG CLEDTDAALC NVFYQIQFIL IRHVQILKQL
VDLINEIREE STFVDRFDES LFRRFAAGLR RYHLILANKS QSIKQYLFVL DVKATVEKSL
EILLDSRFQN FLKQLNADYL ILLSGDAFSL LKLNESVEKK LRYLCELNSV EHHKQSRLLQ
DVFFLPFTVF SDLHLIIAQF NGDDKFTKNT LKMLKSVDRV FRFYKNIASD TRKFRLKHAH
SSFLAEMNEK AQFLVKEFQR GQEPNEFVDV TENGRTVHCY LLAIFSGSFL VVTKSSFKNY
KFPLVWTHNV QDDANLLVKV IVPEGELMIK FRDPSGTKEF VIAFNNALLL YLSKPCSETP
LLCRPPLIRS GTHQFSAQNK TFPGAVYSGS WLLGKPHGNG HLTTKNNCVY GGHFRDGLMD
GYGEYKIVGE NGRWQFNKGQ WRAGVLSGLV FIEYSDGSSY EGYFENNVRH GHGVHRQGSI
LYVGAWQNDK RQGYGVSDEC RSKYLGMWEN DLKHGLGTLV TLDGICYKGV FEKGAFKNGM
MLLTDGTMAK GEFSDVECLN GKASIYFPNG DYLEGFLSGR LQEQLKISSG NFYKNGCCSS
DGIKSEKDKQ NNVHDFENSG FPPAEQKWND IFAHVYHQLN CAENTLLTAD TDKCWQSLVV
VCERFRKYFP THKLQTTSSS TKCSCFLLLV NFFCQSSSWM FNYISAQPIL SKKYQTTACH
AAFQLQYHPL GRLINGLSDI FNVSYSGVSV HSSLLVEAIE EIRSLLKRLY FVIKCLTTYN
TFLYDSYLEL VYPNIFTLFV IKNEELDRVY WMNIRYVNSK SDVMLLDYLG VEKQFWPVIF
TDTSDLDKPL ACATARKKYY ADAIDCFQRL SSEFFPSAKL KIIVETFEHI NKCVSQGACV
EQELTAWTAD SLVPVTTYVI VRAQIQRLGA EINFVQDFCP QLCNVGEMQY IKIKLYTTKL
LFDVRRLAIR FQDESGNPVG TVYDMPFNIT PEQLETVCNM EFRKNEEPLK YSFFVHDLEI
ESSLEETIDM NKINMEQVLL IRYQAHAIYK VQTVTRCTSS LPGHAETVIS ALFSHDGRYM
ASGSGDRTVR FWDLNTELPQ FTCSGMFNFG LKKNIHQLYF LFVFLGHTDW VLCLSWSPDG
QRLASGCKEG KICIWDPETG KQIGKTLVGH KLWITCLCWE PLHQQGTARL LASSSKDHDI
RIWDVVLNQT LRVLSGHTAS VSCIRWGGEG LIYSASQDRT LKMWRVDKGI LCRTFQGHGH
WVNTIALNTD YVLRTGAFDP KDSGNDGTTL PATNPQELKN IALNRYKKFT RNEPEMLVSG
SDDFTLFLWS PSTSKKPLAR MTGHQQLINQ VLFSPDGRII ASASFDHSIK IWCGKTGKFL
HTLRGHVQSV FQISWSSDSR LLVSGSADST LKLWDISARK LIVDLPGHAD AVYAVDWSPR
GDRVVSGGKD KVLKIWRN
//
