ID A0A0V0W151_9BILA Unreviewed; 2015 AA.
AC A0A0V0W151;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Notchless-like protein 1 {ECO:0000313|EMBL:KRX69456.1};
GN Name=NLE1 {ECO:0000313|EMBL:KRX69456.1};
GN ORFNames=T06_7237 {ECO:0000313|EMBL:KRX69456.1};
OS Trichinella sp. T6.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=92179 {ECO:0000313|EMBL:KRX69456.1, ECO:0000313|Proteomes:UP000054673};
RN [1] {ECO:0000313|EMBL:KRX69456.1, ECO:0000313|Proteomes:UP000054673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS34 {ECO:0000313|EMBL:KRX69456.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX69456.1}.
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DR EMBL; JYDK01000356; KRX69456.1; -; Genomic_DNA.
DR STRING; 92179.A0A0V0W151; -.
DR Proteomes; UP000054673; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.20.110.10; Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain; 1.
DR Gene3D; 2.130.10.30; Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II; 2.
DR Gene3D; 1.20.1050.80; VPS9 domain; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR001632; Gprotein_B.
DR InterPro; IPR003409; MORN.
DR InterPro; IPR012972; NLE.
DR InterPro; IPR009091; RCC1/BLIP-II.
DR InterPro; IPR000408; Reg_chr_condens.
DR InterPro; IPR003123; VPS9.
DR InterPro; IPR037191; VPS9_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR46089; ALSIN HOMOLOG; 1.
DR PANTHER; PTHR46089:SF2; ALSIN HOMOLOG; 1.
DR Pfam; PF02493; MORN; 5.
DR Pfam; PF08154; NLE; 1.
DR Pfam; PF00415; RCC1; 2.
DR Pfam; PF02204; VPS9; 1.
DR Pfam; PF00400; WD40; 7.
DR PRINTS; PR00319; GPROTEINB.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00698; MORN; 5.
DR SMART; SM00320; WD40; 8.
DR SUPFAM; SSF82185; Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain; 2.
DR SUPFAM; SSF50985; RCC1/BLIP-II; 2.
DR SUPFAM; SSF109993; VPS9 domain; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 2.
DR PROSITE; PS00626; RCC1_2; 1.
DR PROSITE; PS50012; RCC1_3; 4.
DR PROSITE; PS51205; VPS9; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 3.
DR PROSITE; PS50082; WD_REPEATS_2; 7.
DR PROSITE; PS50294; WD_REPEATS_REGION; 7.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000054673};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 113..185
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 186..236
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 421..472
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 473..524
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT DOMAIN 1376..1528
FT /note="VPS9"
FT /evidence="ECO:0000259|PROSITE:PS51205"
FT REPEAT 1618..1653
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1681..1722
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1724..1770
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1771..1811
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1898..1939
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1940..1981
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1982..2015
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 280..300
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 282..297
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2015 AA; 227893 MW; A903EC1320B9F2BC CRC64;
MKLNVHITIY YFVMKTCLWT RRRGHSLTCL NIDIPYQPDQ LTVYCRDCCA KEANVVFVKD
GIISEATLNV LVDEEGTVFE KRREPLQNVI LSGLRVQSIT FAYETFGAIT SSGNIYMWGR
SNYGQCGIIA ENVVKPEMSV NHVIVEVEIY AVDDYCMHGE RREPYDIQIV QLSIGGSEVL
AVDRNGALWA WGAAFQNGDS TAWQPICLPY RVPGLLGRRV LSVASGRTHH VALVEYIAGV
DELHGLDEYA FLGNSSNCFQ SNLPFVESCE HCQRGRRSVL TDGESTKSSS TDEPSSSPVG
RCPLGVKLSF ADDAECFLEP RPECKPRSKP QARQRKLYSD AHCRGDEVEL YELPRSKQQH
QASSSRLSFI SFDLIMPSSS SSSSLSEQTI ALDDSNALVG CVSGQSIIPG SSNLTGNICL
AELWTWGGNE FGQLGLNDFE PRCEPTRISG SSAFGIVKIA AGAEHSIAMS SSGEVFVWGS
NENRQIKVAD QRRVAVPMLF KAGSCAKVID IAAGEKFSAF LINGIDYRPE CYICGYDRSD
KDGTPVLRLY FPETCWPASL MCSDDYIICG CLEDTDAALC NVFYQIQFIL IRHVQILKQL
VDLINEIREE STFVDRFDES LFRRFAAGLR RYHLILANKS QSIKQYLFVL DVKATVEKSL
EILLDSRFQN FLKQLNADYL ILLSGDAFSL LKLNESVEKK LRYLCELNSV EHHKQSRLLQ
DVFFLPFTVF SDLHLIIAQF NGDDKFTKNT LKMLKSVDRV FRFYKNIASD TRKFRLKHAH
SSFLAEMNEK AQFLVKEFQR GQEPNEFVDV TENGRTVHCY LLAIFSGSFL VVTKSSFKNY
KFPLVWTHNV QDDANLLVKV IVPEGELMIK FRDPSGTKEF VIAFNNALLL YLSKPCSETP
LLCRPPLIRS GTHQFSAQNK TFPGAVYSGS WLLGKPHGNG HLTTKNNCVY GGHFRDGLMD
GYGEYKIVGE NGRWQFNKGQ WRAGVLSGLV FIEYSDGSSY EGYFENNVRH GHGVHRQGSI
LYVGAWQNDK RQGYGVSDEC RSKYLGMWEN DLKHGLGTLV TLDGICYKGV FEKGAFKNGM
MLLTDGTMAK GEFSDVECLN GKASIYFPNG DYLEGFLSGR LQEQLKISSG NFYKNGCCSS
DGIKSEKDKQ NNVHDFENSG FPPAEQKWND IFAHVYHQLN CAENTLLTAD TDKCWQSLVV
VCERFRKYFP THKLQTTSSS TNTADFIEKI PNYSMPCGEQ YYYMVKNYCF QAFQLQYHPL
GRLINGLSDI FNVSYSGVSV HSSLLVEAIE EIRSLLKRLY FVIKVLFPHL PGEQDMESFV
SEFNFDLPLS SCLTTYNTFL YDSYLELVYP NIFTLFVIKN EELDRVYWMN IRYVNSKSDV
MLLDYLGVEK QFWPVIFTDT SDLDKPLACA TARKKYYADA IDCFQRLSSE FFPSAKLKII
VETFEHINKC VSQGACVEQE LTAWTADSLV PVTTYVIVRA QIQRLGAEIN FVQDFCPQLC
NVGEMQYIKI KLYTTKLLFD VRRLAIRFQD ESGNPVGTVY DMPFNITPEQ LETVCNMEFR
KNEEPLKYSF FVHDLEIESS LEETIDMNKI NMEQVLLIRY QAHAIYKVQT VTRCTSSLPG
HAETVISALF SHDGRYMASG SGDRTVRFWD LNTELPQFTC SGMFNFGLKK NIHQLYFLFV
FLGHTDWVLC LSWSPDGQRL ASGCKEGKIC IWDPETGKQI GKTLVGHKLW ITCLCWEPLH
QQGTARLLAS SSKDHDIRIW DVVLNQTLRV LSGHTASVSC IRWGGEGLIY SASQDRTLKM
WRVDKGILCR TFQGHGHWVN TIALNTDYVL RTGAFDPKDS GNDGTTLPAT NPQELKNIAL
NRYKKFTRNE PEMLVSGSDD FTLFLWSPST SKKPLARMTG HQQLINQVLF SPDGRIIASA
SFDHSIKIWC GKTGKFLHTL RGHVQSVFQI SWSSDSRLLV SGSADSTLKL WDISARKLIV
DLPGHADAVY AVDWSPRGDR VVSGGKDKVL KIWRN
//
