ID A0A0V0W1J2_9BILA Unreviewed; 759 AA.
AC A0A0V0W1J2;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=Triokinase/FMN cyclase {ECO:0000256|ARBA:ARBA00018932};
DE EC=2.7.1.28 {ECO:0000256|ARBA:ARBA00012110};
DE EC=2.7.1.29 {ECO:0000256|ARBA:ARBA00012107};
DE EC=4.6.1.15 {ECO:0000256|ARBA:ARBA00012578};
DE AltName: Full=Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing) {ECO:0000256|ARBA:ARBA00032426};
GN Name=DAK {ECO:0000313|EMBL:KRX69641.1};
GN ORFNames=T06_11152 {ECO:0000313|EMBL:KRX69641.1};
OS Trichinella sp. T6.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=92179 {ECO:0000313|EMBL:KRX69641.1, ECO:0000313|Proteomes:UP000054673};
RN [1] {ECO:0000313|EMBL:KRX69641.1, ECO:0000313|Proteomes:UP000054673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS34 {ECO:0000313|EMBL:KRX69641.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + D-glyceraldehyde = ADP + D-glyceraldehyde 3-phosphate +
CC H(+); Xref=Rhea:RHEA:13941, ChEBI:CHEBI:15378, ChEBI:CHEBI:17378,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:59776, ChEBI:CHEBI:456216;
CC EC=2.7.1.28; Evidence={ECO:0000256|ARBA:ARBA00000031};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + dihydroxyacetone = ADP + dihydroxyacetone phosphate +
CC H(+); Xref=Rhea:RHEA:15773, ChEBI:CHEBI:15378, ChEBI:CHEBI:16016,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:57642, ChEBI:CHEBI:456216;
CC EC=2.7.1.29; Evidence={ECO:0000256|ARBA:ARBA00001015};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=FAD = AMP + H(+) + riboflavin cyclic-4',5'-phosphate;
CC Xref=Rhea:RHEA:13729, ChEBI:CHEBI:15378, ChEBI:CHEBI:57692,
CC ChEBI:CHEBI:76202, ChEBI:CHEBI:456215; EC=4.6.1.15;
CC Evidence={ECO:0000256|ARBA:ARBA00000865};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX69641.1}.
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DR EMBL; JYDK01000337; KRX69641.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V0W1J2; -.
DR STRING; 92179.A0A0V0W1J2; -.
DR Proteomes; UP000054673; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0034012; F:FAD-AMP lyase (cyclizing) activity; IEA:UniProtKB-EC.
DR GO; GO:0004371; F:glycerone kinase activity; IEA:InterPro.
DR GO; GO:0006071; P:glycerol metabolic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.340; -; 1.
DR InterPro; IPR004006; DhaK_dom.
DR InterPro; IPR004007; DhaL_dom.
DR InterPro; IPR036117; DhaL_dom_sf.
DR PANTHER; PTHR28629; TRIOKINASE/FMN CYCLASE; 1.
DR PANTHER; PTHR28629:SF4; TRIOKINASE_FMN CYCLASE; 1.
DR Pfam; PF02733; Dak1; 1.
DR Pfam; PF02734; Dak2; 1.
DR SMART; SM01120; Dak2; 1.
DR SUPFAM; SSF82549; DAK1/DegV-like; 1.
DR SUPFAM; SSF101473; DhaL-like; 1.
DR PROSITE; PS51481; DHAK; 1.
DR PROSITE; PS51480; DHAL; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cobalt {ECO:0000256|ARBA:ARBA00023285};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:KRX69641.1};
KW Lyase {ECO:0000313|EMBL:KRX69641.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000054673};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 104..437
FT /note="DhaK"
FT /evidence="ECO:0000259|PROSITE:PS51481"
FT DOMAIN 482..686
FT /note="DhaL"
FT /evidence="ECO:0000259|PROSITE:PS51480"
SQ SEQUENCE 759 AA; 83265 MW; 34C4C6CD6ACCF99F CRC64;
MLELINSWHN SNATVRVNNF QNGPRKRQQS EMKSKYAATQ IMEACPIISS SIDYIISNIN
QNISVEMIWF LISVIQKFLN KFLPPRIELL QDDKHNKSRK LLNSASSCVE DNMQSLCMRN
DKVCKLEKYP VIIRSDLNTV TNVGHVAIIS GGGSGHEPAF GGYVGFGMLT AAVIGEIFTS
PPSQSILAAL HAVRNAAGVM VVILNYTGDR LHFGVAIERA QRLFPNLPVQ FVVVDDDCAL
SEVDLMKCRR GLAGSLFLLK IIGAMAEAGE SLQNISVECD LVKKNLSTIG LGLSTCSLPD
RAPMIDIDQN EMHFGIGIHG ESGMRRIPLM DAKNAVHVMM QTIFTNGFDI KCDDLSDSEK
LFAVMINSLG SVSQLEMNVV TGEVLQWLMA KGIQVVRVYT GTLMTSIDMH GISISLLRID
KEEWIDYLDA PTGCHAWPMG TIPSENLDAY ILKYPSMDSL QIIDEGNDLT RNAITVDEKE
SLEYRNLILT ICNTLKQNEQ KLNYLDSECG DGDCGSTLSK AANIIMVSVE ENLFSTAAPG
KLFSDIALMM EEKVGGTIGA LLSIFFSAGS ACLMNSTDSL AWFNCFIQGV DAIQFYSGTT
SGSRTLLDPM KSLADLLSQQ LLFSDGSPVV TGDFMKHLIE NCEIAVEATT KARPKTGRAC
QVPIELLQKP DAGAYAILLV MNDIVTWSGP MVKSIKAIST TLTDIYLMNN KALTNSKQVK
NTVALGLEVS RSVFHKLKNV MSNSNKTNKR KGFTQKFPC
//
