ID A0A0V0WCB4_9BILA Unreviewed; 1292 AA.
AC A0A0V0WCB4;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=26S proteasome non-ATPase regulatory subunit 1 {ECO:0000256|PIRNR:PIRNR015947};
GN ORFNames=T06_1869 {ECO:0000313|EMBL:KRX73170.1};
OS Trichinella sp. T6.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=92179 {ECO:0000313|EMBL:KRX73170.1, ECO:0000313|Proteomes:UP000054673};
RN [1] {ECO:0000313|EMBL:KRX73170.1, ECO:0000313|Proteomes:UP000054673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS34 {ECO:0000313|EMBL:KRX73170.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the 26S proteasome, a multiprotein complex
CC involved in the ATP-dependent degradation of ubiquitinated proteins.
CC This complex plays a key role in the maintenance of protein homeostasis
CC by removing misfolded or damaged proteins, which could impair cellular
CC functions, and by removing proteins whose functions are no longer
CC required. Therefore, the proteasome participates in numerous cellular
CC processes, including cell cycle progression, apoptosis, or DNA damage
CC repair. {ECO:0000256|PIRNR:PIRNR015947}.
CC -!- SUBUNIT: Component of the 19S proteasome regulatory particle complex.
CC The 26S proteasome consists of a 20S core particle (CP) and two 19S
CC regulatory subunits (RP). {ECO:0000256|PIRNR:PIRNR015947}.
CC -!- SIMILARITY: Belongs to the proteasome subunit S1 family.
CC {ECO:0000256|ARBA:ARBA00006308, ECO:0000256|PIRNR:PIRNR015947}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX73170.1}.
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DR EMBL; JYDK01000184; KRX73170.1; -; Genomic_DNA.
DR STRING; 92179.A0A0V0WCB4; -.
DR Proteomes; UP000054673; Unassembled WGS sequence.
DR GO; GO:0008540; C:proteasome regulatory particle, base subcomplex; IEA:UniProtKB-UniRule.
DR GO; GO:0030234; F:enzyme regulator activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006457; P:protein folding; IEA:InterPro.
DR GO; GO:0042176; P:regulation of protein catabolic process; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.70.260; -; 1.
DR Gene3D; 6.10.250.640; -; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR016642; 26S_Psome_Rpn2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR019330; MESD.
DR InterPro; IPR048570; PSMD1_RPN2_N.
DR InterPro; IPR040623; RPN2_C.
DR PANTHER; PTHR10943; 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10943:SF2; 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1; 1.
DR Pfam; PF13646; HEAT_2; 1.
DR Pfam; PF10185; Mesd; 1.
DR Pfam; PF18004; RPN2_C; 2.
DR Pfam; PF21505; RPN2_N; 2.
DR PIRSF; PIRSF015947; 26S_Psome_Rpn2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Proteasome {ECO:0000256|ARBA:ARBA00022942, ECO:0000256|PIRNR:PIRNR015947};
KW Reference proteome {ECO:0000313|Proteomes:UP000054673};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..1292
FT /note="26S proteasome non-ATPase regulatory subunit 1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5006871576"
FT DOMAIN 183..328
FT /note="26S proteasome non-ATPase regulatory subunit 1/RPN2
FT N-terminal"
FT /evidence="ECO:0000259|Pfam:PF21505"
FT DOMAIN 360..573
FT /note="26S proteasome non-ATPase regulatory subunit 1/RPN2
FT N-terminal"
FT /evidence="ECO:0000259|Pfam:PF21505"
FT DOMAIN 1017..1127
FT /note="26S proteasome regulatory subunit RPN2 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18004"
FT DOMAIN 1153..1243
FT /note="26S proteasome regulatory subunit RPN2 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18004"
FT REGION 332..352
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 521..546
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1068..1163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1252..1292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 333..352
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1068..1104
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1113..1128
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1145..1163
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1268..1292
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1292 AA; 144599 MW; EFD1FE2E22AF97A1 CRC64;
MYIYLMLVFC LTNTTAVEVE EMPADHPQVY TMKPPVNKHP RDYTEADLQG LFDQWEANDD
PLDPDEIEGW RKPPPLDLNL LKVHTSEQAS RIIKKDREMK LFVKFDPKMS RAEIDDLTNI
WLMRFFNNHI VSKRRFSQEK EVEFLFIEGS QAWDAYHFVM DQDEVYEVML EGNKYKGKAQ
LRGFTSLLDE QSVALQVYAL ENLDNLVPSF WHEIADCVSR IEELYEDENF PRRKLAALLA
SKVCVYYYLG IYKEALKYAL YAEELFDVKI HSEYSETIVA IAIDEYIKLR NVEKQSERVG
QDWRKNNYDR DKVEERRARI MKQKIKANRN KRKLNIKKEE PEKPKNDEEE DRKNIEAALD
KDCESEAITD PRLEAVINRM FDRCFAECEF KQIVGIALET RRIDMLNKAL IESEDTVELA
TYCAKCTVQF VQNRTYRNEV FRHLVELCSS SPLLDYNTLC QCLLYLENPQ QAVDCLKKML
VGSKESVLAA YQIAFDLFDS ASQQYLTGML KCISPSEVEE KSDKTNVENS DSKNKPKEEN
AKSEEELQLE PLRRILSGEL TIFAHMQFLI KNNRADLQIL KNIKDTVRSS VCHTATVIAN
GIMYCGTTCD DFLRNNVDWV SKANNWSKFS AVASLGVIHK GHETEATRLL ESYLPKDVVS
ATSSGYLEAG GFYALGLIHA GHGNETLFAR LQRELNSTNN EVLRHGLCLG FGVAALGSLR
ADLCDDLRTI LFQDEAVAAE AAGIGIGLIL AGSLDYEVFK EMYMCATDTQ HEKIQRGICV
GIACIAFGRM EQANSWADEL LKDQNPILRR AGVYTLAMAY CGSGNTNVVG RLLHLSVSDV
NDDVRRAAVS SIGFVMSRNP TACPQLVSLL MESYNPNLRY GAAIALGVSC IASGLREAIA
LLEPMLDDTV NYVRQGALIA MAMVLMQHNE CTAPKVKDFR EKLMKIIGDK HEDVISKFGA
IIAHGLLDAG GRNVTVSIIG RNENVSMITA IGLLVFLQSW YWFPLAHFIS LALQPSCLIG
LNSDLKMPNM TFISNAKPST YAYPPQIVEK QAKNPEKVVA AVLSYTHKSR RREREKQAKQ
QEQEEKMDVD EAAVNKKKDK DVPDAAATAT QATPAIPVES STPAVENVPS VDKNVAETAE
PKAAATPGDT TTTTTAAPAT TDTVATTTSA AAVGTGDAEA ENKPAVVEPE PTFDTLNNPA
RVTKLQLKVM TMPDDSNFIP IKPITHGGII LMNEKSAEVA VDFVEEVKAN VPLGDEEAEP
TAPSPFDYFI ENESNGQNQE QTQTDNASAA TQ
//
