ID A0A0V0WQU4_9BILA Unreviewed; 1129 AA.
AC A0A0V0WQU4;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN Name=him-6 {ECO:0000313|EMBL:KRX78093.1};
GN ORFNames=T06_7508 {ECO:0000313|EMBL:KRX78093.1};
OS Trichinella sp. T6.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=92179 {ECO:0000313|EMBL:KRX78093.1, ECO:0000313|Proteomes:UP000054673};
RN [1] {ECO:0000313|EMBL:KRX78093.1, ECO:0000313|Proteomes:UP000054673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS34 {ECO:0000313|EMBL:KRX78093.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: Belongs to the helicase family. RecQ subfamily.
CC {ECO:0000256|ARBA:ARBA00005446}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX78093.1}.
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DR EMBL; JYDK01000072; KRX78093.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V0WQU4; -.
DR Proteomes; UP000054673; Unassembled WGS sequence.
DR GO; GO:0043138; F:3'-5' DNA helicase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR GO; GO:0022414; P:reproductive process; IEA:UniProt.
DR CDD; cd18794; SF2_C_RecQ; 1.
DR Gene3D; 1.10.150.80; HRDC domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR004589; DNA_helicase_ATP-dep_RecQ.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR002121; HRDC_dom.
DR InterPro; IPR044876; HRDC_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR032284; RecQ_Zn-bd.
DR InterPro; IPR018982; RQC_domain.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00614; recQ_fam; 1.
DR PANTHER; PTHR13710:SF105; BLOOM SYNDROME PROTEIN; 1.
DR PANTHER; PTHR13710; DNA HELICASE RECQ FAMILY MEMBER; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00570; HRDC; 1.
DR Pfam; PF16124; RecQ_Zn_bind; 1.
DR Pfam; PF09382; RQC; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00341; HRDC; 1.
DR SMART; SM00956; RQC; 1.
DR SUPFAM; SSF47819; HRDC-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS50967; HRDC; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000054673}.
FT DOMAIN 410..587
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 612..760
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 961..1042
FT /note="HRDC"
FT /evidence="ECO:0000259|PROSITE:PS50967"
FT REGION 1074..1118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1102..1118
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1129 AA; 125506 MW; 5E9F72AF96428C6A CRC64;
MSGRRFKFKK ICDLQAKAVV STPVLLTSKA IQISSPIRID SSGAFKNDTR CSTVSTSSGT
VAGGGFNRRK LQLPTGEATV FKNSTSLNTA LESNRPEDYI FDDVPFADSF PDDDHVTFPP
TVVGSGQTNV ANSCAIPQRL IDEFENEDED NFLLMVDQTT QSNLAQISNS NTSGGNLSWN
SEIGSPELGI FTSTPKVRSQ EVKSNYKIKT ITTDQPKVEE TVEFVVESGE AISIEKLRSV
ICSVEKDLAD SVVELEKRLN ILSVIICNLL EKLAISKIVS LLPESLRDVY QTAALMRKKL
IARRRALVKR SNSGKRLEEK KQWSPYFSAP LPTVEEQQDV EREKPLPTAE PACQRISPLK
LGAHGKFRSF VRDDSAEFEH TNFEHSVGAR RTLVQVFGFR SFRHKQLAAV NAILLNYDCF
ILMPTGAGKS LCYQLPAVLG SGVTVVVSPL KSLIEDQVHK LNQLQVPALA LCGDVPVSRL
SFQSTGEFGG QWSATVKLVY VTPERLSASS KLLEMLDDLY RRQLLSRFVI DEAHCVSQWG
HDFRPDYKRL FLLRQRYVGV PIVALTATAT PKILVDTKKQ LNMPQAKLFV SSFVRSNLSY
KIFEKDSKCL QTIVSLVKGI YANSSGIVYC LSRKECESVA KLLVSHGVRA EPYHAGQADS
RRSKVQRDWI CGKVLVICAT IAFGMGIDKP DVRFVIHHSM PKSIEGYYQE TGRAGRDGLP
AHCLLFYSYH DSVRLRKLME SEMSASKGTT ALEMHRRNLL EMVAYGENVG VCRRKLLVEH
FGEIYDSAVC KANLATACDV CKRRHSPSLF DLTTDCRLLV ETYRAMRRDP HRRVTLKQLA
DVYRGAQTKG IHAAGDSRLA VYGRGAGLGS KGALRVLHQL VCEGVFVEQL CTTASEHVVS
YLELGPMVDR LVSGDKKVHV YLESSTASGT SGSGQLQQQQ EFWTAVTEGM MAMEKNRFKH
ADISERCLQT LNQLLCEMAE RENLPNRNAI LNAEALNQIA GWLPRTQSEL LAVDTMTEAK
LAKYGPLLMR ALEPFWEEVD RRESERITTE LAVLDNAVDM SAVFGIPVAQ PSPLANAPRK
RVWKSTSTRR SGTGKTATRG RKPVKTPSKA RRTAAKVKRT KALPLVHIR
//
