ID A0A0V0WVE2_9BILA Unreviewed; 1762 AA.
AC A0A0V0WVE2;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 30 {ECO:0000256|ARBA:ARBA00019664};
DE AltName: Full=Mediator complex subunit 30 {ECO:0000256|ARBA:ARBA00031981};
GN Name=Vps11 {ECO:0000313|EMBL:KRX79698.1};
GN ORFNames=T06_9800 {ECO:0000313|EMBL:KRX79698.1};
OS Trichinella sp. T6.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=92179 {ECO:0000313|EMBL:KRX79698.1, ECO:0000313|Proteomes:UP000054673};
RN [1] {ECO:0000313|EMBL:KRX79698.1, ECO:0000313|Proteomes:UP000054673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS34 {ECO:0000313|EMBL:KRX79698.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC the regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors. {ECO:0000256|ARBA:ARBA00025687}.
CC -!- SUBCELLULAR LOCATION: Late endosome membrane
CC {ECO:0000256|ARBA:ARBA00004492}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004492}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004492}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 30 family.
CC {ECO:0000256|ARBA:ARBA00010606}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX79698.1}.
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DR EMBL; JYDK01000049; KRX79698.1; -; Genomic_DNA.
DR Proteomes; UP000054673; Unassembled WGS sequence.
DR GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0099023; C:vesicle tethering complex; IEA:UniProt.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR CDD; cd16688; RING-H2_Vps11; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR000547; Clathrin_H-chain/VPS_repeat.
DR InterPro; IPR018790; DUF2358.
DR InterPro; IPR021019; Mediator_Med30_met.
DR InterPro; IPR022127; STIMATE/YPL162C.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR23323; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN; 1.
DR PANTHER; PTHR23323:SF24; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11 HOMOLOG; 1.
DR Pfam; PF00637; Clathrin; 1.
DR Pfam; PF10184; DUF2358; 1.
DR Pfam; PF11315; Med30; 1.
DR Pfam; PF12400; STIMATE; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50236; CHCR; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000054673};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT TRANSMEM 559..581
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 625..645
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 675..699
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 720..739
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1609..1647
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 1..97
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 162..199
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..81
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1762 AA; 201962 MW; 078A35450678405D CRC64;
MSQQNQNSFI QTFPLPPRPL NSNGNNLDAN YGYPQGIGPS SVSSPIQSLV NSFGSRREVP
SPSPASVSES TNVAPGKTTQ ADESQQEHHA EREAWSAQGS KAFNVNPFFA FSMSQILQSN
DNNGPLALCI IGRDFTREVI NRTCDICGAL KSLQLPTAPE AVKQHQDKLQ RINESLKQVN
IILERLEAID RKIDNFRKEL LPADAEDHLK DLVTYDGKNE WLRKLTEERK SREVFTQTKQ
QYDEVKKELE THAPSCSARS FNFCSLKLAQ FDPREFGLRL KPYIANSDDI HIPFRRPFFS
CTNSLIYPDY NSYFIPIIRN LSSKKSKNDS VSESLVKRRV SFNFSAVYSQ VVNQCSSTEK
SPTHYFERGK PNWDQLQHVI YRLSETVPTF FLRRLDYTFY SDDVLFLNRI CGSEVKGLRN
YWLHLATLSV LSRIPCPYIE MKILNCMPIV EEGSVHLRWR VLYLTVPEFL YVVVRERSAD
IETLRRNARW FDGFSYFYVG SDGLVYKHVA DRVMRDPEEI AANSKRVGLL NRLLGSSARS
PIWKQFNLDK EKKNLVDSYG LSIQLILATL AFASLIVKRL LEPKQTRRPW TIWFFDTSKQ
AVGSSVIHAM NIFLAGVFRG DPCTWYFVSF LLDSTLGLLI IYTGVKLVTA AASCRKDWST
LRFGEYGDPP QCRPWLHQCL AFVILSVIEK FFVTLLLLMR FWKSVREIAL SPIRNPKVEV
TLVILVFPFL INTIMFWVVD NFTMKRRAVS KKFNSNNSNS LIIANNGSSS SGIRRVHDES
AVKLLDEYDN NSQQNDALAL FPADNILQHR NSSTLAGIFV FFIHFNSDCE SSTIIMASSL
FQSWRRLVFF DRQLIADVEN ADESFTEFKD LNIACVAWKS NRVFIGEVDG GVHMYDKDFS
DTYFKAYKVN LSLLYCPRSS DSLVSIGEDD NGVNPYLKVW LLDKLDKQGK PFAVRCSKTS
PGNRPVKVTS VAVDSSGQLM VVGFEDSSIL LYRGDVCKEK QPKSQLIRDG STCASEGSIV
GMELCDHSSQ AVILYVVTTR FTFSFTISFK EKDITKTVLE IEGLHMRRCW ALAGEELKNQ
FVVARNMGFY FYQPEEKAYE ASFPDISEVF IAWNFIFILC MESGKLFRLK EMSIESQLDI
LFRKNLFDLA ISIGEKQCQQ EGTVEYLSIL RGLFLQVRLD TDCFQCFEVE LLKNRKRDYS
NALKQYMRTI GTLDTSYVIR KLLDAHRIEN LAEYLEAVFH AKLGTVDHSN VLLSCYIKMN
AIDKINSFIQ NKETVAPLDV EAAVKLFRKF GLYRQAAFLT KRHGYPKRCL DLLVSDLKDF
KQAINYISSL ESDVIAEFFT RYSKLLLENV PEETMTLLGE ILKRDGCSEK NWVQSVVLRL
IAHPDRLEAF LEQSLMANKV DVKLYNLLLY AYLRRYSSTM ENDVAKEQIS RKIDQLLKNI
SSDNQSLLEA LRFCYQWAYH PGILYLLERQ KMYSHLLKHQ MFLKDYDSVI SACLKYGDRR
SGDKTLWSFA LQYFSEDPTI SEEYVKKLLT SSELTGDVHP MLAVQTLAKS KTLTFACVKD
FLSHWVDKES KSIEMDEQDS LRLCNEIKRT EAIIDDIQKN PQIFQMSKCT ACDIILETPT
VHFLCKHSYH QHCFENYAES EAECPVCLLD KKRFQNQCKT DSSTSSEALN HSFKEELMNT
NNVIGTLTSY FGKTLFPDKD VDAENCEIHQ QDTSKSVQSL NPFEGELRIS NDSSGVILSA
KYSSFDLHKF TLLNFCFVMP NA
//
