ID A0A0V0X0M3_9BILA Unreviewed; 1024 AA.
AC A0A0V0X0M3;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN Name=mcm5 {ECO:0000313|EMBL:KRX81171.1};
GN ORFNames=T06_6097 {ECO:0000313|EMBL:KRX81171.1};
OS Trichinella sp. T6.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=92179 {ECO:0000313|EMBL:KRX81171.1, ECO:0000313|Proteomes:UP000054673};
RN [1] {ECO:0000313|EMBL:KRX81171.1, ECO:0000313|Proteomes:UP000054673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS34 {ECO:0000313|EMBL:KRX81171.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the MCM family. {ECO:0000256|RuleBase:RU004070}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX81171.1}.
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DR EMBL; JYDK01000034; KRX81171.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V0X0M3; -.
DR Proteomes; UP000054673; Unassembled WGS sequence.
DR GO; GO:0042555; C:MCM complex; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0032508; P:DNA duplex unwinding; IEA:InterPro.
DR GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR CDD; cd17756; MCM5; 1.
DR Gene3D; 2.20.28.10; -; 1.
DR Gene3D; 3.30.1640.10; mini-chromosome maintenance (MCM) complex, chain A, domain 1; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR031327; MCM.
DR InterPro; IPR008048; MCM5.
DR InterPro; IPR018525; MCM_CS.
DR InterPro; IPR001208; MCM_dom.
DR InterPro; IPR041562; MCM_lid.
DR InterPro; IPR027925; MCM_N.
DR InterPro; IPR033762; MCM_OB.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11630; DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER; 1.
DR PANTHER; PTHR11630:SF42; DNA REPLICATION LICENSING FACTOR MCM5; 1.
DR Pfam; PF00493; MCM; 1.
DR Pfam; PF17855; MCM_lid; 1.
DR Pfam; PF14551; MCM_N; 1.
DR Pfam; PF17207; MCM_OB; 1.
DR PRINTS; PR01657; MCMFAMILY.
DR PRINTS; PR01661; MCMPROTEIN5.
DR SMART; SM00350; MCM; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00847; MCM_1; 1.
DR PROSITE; PS50051; MCM_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004070};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004070};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU004070}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000054673};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 771..792
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 855..876
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 907..925
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 946..966
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 986..1005
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 332..537
FT /note="MCM"
FT /evidence="ECO:0000259|PROSITE:PS50051"
SQ SEQUENCE 1024 AA; 116120 MW; C0C1C59947456531 CRC64;
MSGFDRAEIQ YSGQDEQKRL ELALTEEGTL KFAKSKFKNF IREFNYGSFA HIYRESLRNH
CKLGKMYLEV RLQDMRSYNS DLAYIFQKNP TEVLPMFEEV TKDVAEETTY QGSSEVNTLP
NMQVIITSDE NSQPVRSLQS KQISKVVKLR GIIVSTSQVR CKATEISIQC RNCQLTVNNI
SMQPGFDGYA LPRRCNSNQI GQQQKCPVDP FVILPDKCRC IDFQVLKLQE CPEDVPHGEL
PRHMVLYCDR YLTDRVAPGN KVSVLGIYCI RKQHKMTRRE KAGKPSAGLR QPYIRVIGIE
VESSGLGRTA PHALLSPEDE KQMRELAAQP DIYERIAKSI APSIYGSEDV KKAIACLLFG
GSRKRLPDGL MRRGDINVLL LGDPGMAKSQ LLKFVEKVSP IGIYTSGKGS SAAGLTASIV
RDASSRSFVM EGGAMVLADG GVVCIDEFDK MREDDRVAIH EAMEQQTISI AKAGITTTLN
SRCAVLAAAN SVYGRWDATK GEDNIDFMPT ILSRFDTIFV IRDVHSETRD LALAKHVISV
HVGADSEAVR DEEATDGEIS LATLKKYIAF CRTRCGPRLN RSATRKLIHS YTRMRNVPVA
QQQKDLHIAY QKSSIPITVR QLEALIRIAE ALAKMELSPY ATDRHVDEAL RLFQVSTLAA
ASQGTLSGVE GFSTKEDQEQ FIRIERQIRK RFPVGTQVAE HVVIQDFITQ GYQEATIRKV
IYAMVRRGDL HHRLQRKMLY RKSEMMEKSF YKVNVTDHFE LPMQSASFVT IVRQVGGVLT
ISALNGIGYL LNGIRFSNLR KRNYFPMVPV KECLLTHPDV TLSYFNYTLR PFLLVYLAVD
RMCAVLLEVK NMKKVTTYGV ISVYVLSLFY VIGAWIETFL LRSDCMIKQN CIYWSAVPWY
HQKFQKYIHI FGLFAAVAIV IMALLRAYVK RRKEVHCTTW SFANDYLAVT SRLSIIVFSE
FIFRGLPLLW GCFVTRTISM YTVRMTLYVF SDIIEAFYGV LYCYINKDLR ESIVSLCRLF
GGCT
//
