ID A0A0V0X6H5_9BILA Unreviewed; 1751 AA.
AC A0A0V0X6H5;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 03-MAY-2023, entry version 22.
DE SubName: Full=Telomere length regulation protein TEL2-like protein {ECO:0000313|EMBL:KRX83631.1};
GN Name=Telo2 {ECO:0000313|EMBL:KRX83631.1};
GN ORFNames=T06_1244 {ECO:0000313|EMBL:KRX83631.1};
OS Trichinella sp. T6.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=92179 {ECO:0000313|EMBL:KRX83631.1, ECO:0000313|Proteomes:UP000054673};
RN [1] {ECO:0000313|EMBL:KRX83631.1, ECO:0000313|Proteomes:UP000054673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS34 {ECO:0000313|EMBL:KRX83631.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the TEL2 family.
CC {ECO:0000256|ARBA:ARBA00006133}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX83631.1}.
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DR EMBL; JYDK01000012; KRX83631.1; -; Genomic_DNA.
DR Proteomes; UP000054673; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 1.10.8.1120; Histone RNA hairpin-binding protein RNA-binding domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.25.40.720; Telomere length regulation protein 2, C-terminal domain; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR029344; SLBP_RNA_bind.
DR InterPro; IPR038294; SLBP_RNA_bind_sf.
DR InterPro; IPR038528; TEL2_C_sf.
DR InterPro; IPR019337; Telomere_length_regulation_dom.
DR PANTHER; PTHR15830; TELOMERE LENGTH REGULATION PROTEIN TEL2 FAMILY MEMBER; 1.
DR PANTHER; PTHR15830:SF10; TELOMERE LENGTH REGULATION PROTEIN TEL2 HOMOLOG; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF15247; SLBP_RNA_bind; 1.
DR Pfam; PF10193; Telomere_reg-2; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000054673}.
FT DOMAIN 82..258
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 288..383
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 408..436
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 640..720
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 852..884
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 411..436
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 683..700
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 856..874
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1751 AA; 200319 MW; F394F8E7247EDBF6 CRC64;
MHSSKRQSEN KLRGKKFQFI QLEMFISRFP VKSDNCCPFA MCPTRSCTRT KFKQIKRKWI
LVMEKMSEKC DGGLPEPSTE TQLAKIYDEF VTSERHYLEH LDLVIRYFAD PLLCSKILTQ
REVANIFGDL RSIRLVNQVL YDRLMAGLEI AEAFGDLIHF MKLYSAYGRN YSASQQLLLQ
LLEKNKHFRQ FCEMQECLPV LKGLKLAALL ITPIQRIPRY KLLLEQILKL LDNSSRQHLQ
ISKLVQQIGA LAETVDSCIE EFENSAKIIA VQNMLDGCAP KLVMPGRKLL KEGLLNKMSS
SNSGFRHRMF WLFTDIILYA KPAMKKKNRY QCCCILPLRH CMIERILGRS MFRLICKDEV
LLLHAEQYSV MDEWVVAIEN AIRYLLECRK SLRKESSNSF PMHRQALKLH RSRSSFTEKL
SSRKTQIPND DPKPTKKRRS FLLSLLSKLG GRWSSRNRRQ SGDDSLAEVE TNNSRMTNSV
SLFSTGSRLP LDNIAEETSI LGRRPKEPPP KNHRLTLVLC KKSRMKMSPI PLNWLLKSNR
YDYSRRLESS SLSTSGIKSS VFELFGECDD YVLDFGEKSW ADIMEEEELY EKEKLSRMNT
QQNEANVIAP FVEESTSETI VPEHEVAAVD FSQLHSTYAQ QMLSKSEPSH EEPSTFARRN
RRMRRPVAPG PRASKQAEAD ANEELKQGSQ WTTARQPHLL NEENTLEAGD VESDKRKEET
LPEVVKPVEE APKKRVGPPL RYPLPATWRE PTNGWEEDQA VLKRRQKDLD KGYNSEAYKK
YIAAVPKSKR EKGIHPRTPN KYLKFSRRSW DSQVRLWRKM LHVAVGEEYN SDASFVSSSS
CSDASSVVSE NEVTSLRRLS ENEESVEDGR KVDPVNESIP TNQQDDETLT ESVHLICQSL
ESKKFASYGA LHSRKAMSEC KSTTTTLLKR LLSASSRLEL RSCLLDIGNY VVENQNFGSF
FRVGEVLLQT LKPSTFNMLL PVEQDELFYS IFLRANPADV VLLLSKPPDR ISPFVVPKFV
LIVERFCQHK LDQLFTSMAN ADDGRRPCDR SMQGQLCQAL FAIPDRMVGL LKPREAKKRL
TVYWNNFCSA YVRSLGQIDD QLTGAVVNKS ELEMSFHGAL LGKACLTGRQ RRFLEALLPF
ALRRARNARR RGRRAWFDQL FRACPADAVK QLFTDLILLL KSASDLHTLV DDFGVVDDQA
RFVLSRSLLF TSHFDTATVP RLVIGYLKLV GGEQEKVLLQ EIFLLSLQNW SFKSSIVNTT
VQQQRYVAQT LLLTAKELVR RHWMEELENQ AAPFVLDGMY NHLGGLSSNV QQLGMVVGEA
LVSMLKMPVE DVKFNYEEDD FVASLRAMLE DELPLSEQES AEDILSDFAV LSVDSTDETI
PIQINLRDSD DDEDEDNSET MTDHYQLEED EQLMRRRKGQ SSQLSYIEDC LEQLLCVEND
DYDCFEMALL SLEKVLFKER STPGVGELAG HAAKVLLHLE NKFAQQLHDQ LRVKCLVGCV
ISDPLNVAAY LCQEFHSRAL TVGMRVEVLR VLCTAAELLS RDANNNTKQK QQHVENSLLK
SGALAPEQWV RDGWRAVLQQ RIEAKTVRRQ KYDYQSADRC RVNRFASIAA GIFDMLIDRR
HTVHSTALRE PLVLGVFVHT LATLLLAAGH SAQLRSMAKL TITVGWPEHC NHEEPLVRAG
LLFAFLAVLS RLPVELLFAD LGEQNLRERV DWLERVRTGD LDPNCRQLAE LTLNTWNQAI
LRMADQIFTC N
//
