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Database: UniProt
Entry: A0A0V0X727_9BILA
LinkDB: A0A0V0X727_9BILA
Original site: A0A0V0X727_9BILA 
ID   A0A0V0X727_9BILA        Unreviewed;      5141 AA.
AC   A0A0V0X727;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   10-MAY-2017, entry version 11.
DE   SubName: Full=Ryanodine receptor 2 {ECO:0000313|EMBL:KRX83685.1};
GN   Name=Ryr2 {ECO:0000313|EMBL:KRX83685.1};
GN   ORFNames=T06_3200 {ECO:0000313|EMBL:KRX83685.1};
OS   Trichinella sp. T6.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichocephalida; Trichinellidae; Trichinella.
OX   NCBI_TaxID=92179 {ECO:0000313|EMBL:KRX83685.1, ECO:0000313|Proteomes:UP000054673};
RN   [1] {ECO:0000313|EMBL:KRX83685.1, ECO:0000313|Proteomes:UP000054673}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISS34 {ECO:0000313|EMBL:KRX83685.1};
RA   Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT   "Evolution of Trichinella species and genotypes.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KRX83685.1}.
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DR   EMBL; JYDK01000011; KRX83685.1; -; Genomic_DNA.
DR   Proteomes; UP000054673; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd00051; EFh; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF13499; EF-hand_7; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00054; EFh; 2.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 2.
DR   PROSITE; PS00018; EF_HAND_1; 2.
DR   PROSITE; PS50222; EF_HAND_2; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Calcium {ECO:0000256|PROSITE-ProRule:PRU00448};
KW   Complete proteome {ECO:0000313|Proteomes:UP000054673};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|EMBL:KRX83685.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054673};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4490   4515       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4690   4709       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4750   4776       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4894   4916       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4939   4961       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   5020   5039       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      103    157       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      164    208       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      218    272       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      278    339       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      344    402       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      582    817       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1045   1226       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     4241   4276       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   DOMAIN     4279   4311       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   CA_BIND    4254   4265       {ECO:0000256|PROSITE-ProRule:PRU00448}.
FT   CA_BIND    4289   4300       {ECO:0000256|PROSITE-ProRule:PRU00448}.
SQ   SEQUENCE   5141 AA;  586042 MW;  549422BA5FC0576F CRC64;
     MTDFQENSTG EQDDISFLRT GDVVCLTCLA PCKESGTGSA ERVSLAAEGF GNRICYLENV
     SDKNKPPDNA TSMFYIDQAL SVRALQEMMS SESPNISGSS STHRTLLYGH AVQLKHALSG
     MYLTCLSTSS ASDKLAFDVG LCETNVGEFC WWTIHPASKQ RSEGEKVRFG DDVILVSVAT
     ERYLHMSSTN GNTVLAAFHQ TLWSITPNSS GGVRERHMGY VCGNDVLRLN HGNDECLTIP
     ENWSDSHQNN IVIYENGKSC NQARSLWRPE LIHGKWQSSL IGWEQAFRIR HITSGRFLAL
     NEDNQVCLLH KDRASFESTA FIMISSKDVK RSTFEEKEEE GMGVATVKYG ETVIFLQHLQ
     SNLWLSCQTT AVTKKNMGKV EEKKAIAVEE ARMDDCFILF KAQEEESQSA RVIRKCSQIL
     NRFLRGLEGL QMEGKDSLAW NRADLSETVK LMEDLIQYFA QPEESVDFES MQNGLRALRN
     RQDLFQEEGL LNMIIDTIDQ FSAVESMTEL LDVTKEDKCK NWQDISTYLY LLVAAMIKGN
     HSNCTQFASA QRLNWLFSRL SNPQSAEGIL DVLYCILTES PEALNMINED HVKAVISLLE
     KVGHDPKVLN VLSALCEGNG VAVRNSQNVI CSELLCNKKF LLQTKMIDQV SSVMANIFVG
     SYENSAMYPR WYFEAELEYM ESMRTSGQKP HLRIGWASSA GYRAYPGSGK KWGCNGVGDD
     MFSFGFDGQY IYAGIEALKL SKLIGGIEKF VGTHEIRKGD VIGCSIDLAI PEIQFSLNGH
     QIGTSVRNFS SCDCLFYPVM SLSAIVSCRF FFGGSQGKLR FGPKKGYLPI SEAAITPVKL
     ISCISFGDTR KGYFSGPSTV ISDYIVFQPK PIDTKDVSLP KHLEDVHEKL AENIHEVWAM
     DKIEKGWIYG ERRSETQKIH PCLTSYERLP TAERSYNLNL AKETLKTIVA LGYRIDIGKA
     SNRVKTFRLG QNFLMSNGYK PAPLDTREYE LNETLETLVD LLAKNMHNIW AQSKIQRGWT
     YSKNENVNIK TTSHLVAYDF LDPNIKAANR DKAGQIIRSL LVYNYCIEPP TAEQDEGAVK
     QSQVMNLQKR TYRFEKRYAV KSGKWYFEFE VRTSGFMNVG WMDVSASPDG DFGLHKSSYA
     YDGYLGRKWH GESESYGKKW NVGDVVGCFL DLTDRTICFS LNGELLLDSS GTEVAFDNVS
     AEDGFVPAFS LAPGQIGRLN CGQNVNTLKY YTTCGLQEGY EPFCIRMSRQ APMWIAKCEA
     EFDEINEEEK RFKVTRIPQS GDNPPCLKLQ CKSAGMLERC SLALFRLNLP VFCKEANDNR
     VCNQYFTETL SERNAGKRNG ESDRTAESSR RGKMKGIRGS RNQDENISFH DQQNYADQYE
     VSNHAVMKSN CLVQKTFSLD DDSSEVTENR FRKAPRLRSS ASEANLKEKE SIDSQDKISA
     SYAVSNTKRN LRPFKVLQSF GQRMRDVSVG RSRKQNARKL QEACASKSKI RSDENDKFSS
     GHLNSRKLDD RVADVDSTES LDMPKSGPGR RPTVIRLESD SKVKKRSNYF SSGHDLLVEA
     SKLSAPSGNQ HVSIGASVSF YSTPDDYYFG VRVFPGQDLA NIWIGWLTPQ FSFTGSQIAA
     DSQRICFLES THSTLDNIQE FRSCYIVNGM ELLTAAGGSS SVSKMAGILA GCLINTATGE
     LKFHVNGKQT EMSYRVEPGT ILYPAVFVLP TSREVLQFEL GSIEKTLPIA SAQLNERSNA
     VQLMCPPRLK MEICKTRTWL RVPDQCARVT SLKLSDTRGW SVLCDDLVRT MMLYVPERDS
     SIDILELAEH ESLCTFHQQT LRLYCSLCAQ GNFKIAHILC QHVDEDQLMY AIQSKYLSGS
     LRQCFYDVLI AIHLKCHYDA RLAESHEYII PLNAKLKDRN YFNYETKSVY PHALNSDITL
     KSSINVMEVK KKISTEDEKF LMSPTFDFHT LKQYVVDALE EATLEALMNS RDLIGGTNTT
     HFLPILKLFD TLLLVGVLSD TDIHRFFRLL NPKSFQETLD SPQNVKGLVD LDLDEMVQLE
     LCHIMNHLCD LQLQGRVESL INFAETFVGE TQNACALDEI FEKSNLCFNY LRVMFDMPSA
     EAARKTKEFR CPPKEQMLKL LDFKADRDEQ TDEEGELEVS AMSEFLQRVL REFHCNMVKF
     IGNSDKNDDN YSANVEQKQL ESENMNWVEK LAWMVVPVPP ALLSEDERIK FDGEEAFRNI
     ILSTLIKWTG NKAIDDPNLI REIFGLLLRQ YTRISEVKSA LKTAYCIHER SIEDVQSFLD
     NLCQIRRLLC VQFEATEEEV LKNSLWDMMN NKVFFQHPDL MRLLKVHENV MTIMVNVLSR
     AQKSELDDRR NRSAQDDMKK AFQNSISDLV VACCKFLCFI CRSSTKNQAA MFEHLPFLLD
     NATMLLAKPS LRGSVPLDVA YYSFMENSEL ALALKEDDLE KVAFYLSRCG LQANAEMVFK
     GYPDIGWDPV EGERYVDFLR FCVWVNGECV EENANLVIRL LIRRPECLGP ALKGQGEGLF
     RAFKDAISLS SEISNLHKGR DLRSRFNFDL SHYPNPEIEE EDYIDLGAAI LGFYSSLADL
     LGKCAPDHLT VKSGKGESVR LRSILRSLTS VEDLEAILAL RFLLPNVFAA KEENSRSSSI
     GLLPCHKQSI LLFLERVYGL IDKEMVFRLL EQSFILDFRA ATILDHPAYA ESDLALALNR
     YLCGSVLPLL TSHAHCFADA EHYYSLLEAT LHTVYRMSKI KSLTKSQRSA ITEFLLAFTK
     EIHPGMMKKL LQKVVVDISS LNEFATVPLQ IMTQHYECFS KHYGISMHED TASEEQKRLS
     MLLFTTIFDS LGKRAFDSDL FASALPCLTA IGSALSPDYA MQSYAEEEIQ NMNVPSGHME
     VWRPHPVDAS NVQLSVNLQN LVQRFAQHFH DSWASRKLEK GWRNDDIYSR TNCTHPRLKP
     FGMLKEFEQN FYKERCSECL KALLAWGYSI EQETQVSSVQ PKSMNPTSNV RSASVFCPQP
     IDLSNMTLSE EMCELAERIA ENSHLIWVSK TIEDLNDANT GIMVLLVPWD ILADSEKRKH
     RFRAQEVLKF LQYQGFRLKS PLHRTREEYQ QTVVDSNTHR PVEKRFACNL LEKLLAYLEN
     AAQKMEVIKP SKQFSRYRNY TLPSEDVKFF GKVTDHIILA INLIFCLLKV LLPLLESYFR
     SHRNYFTAAS SASLSGVASI KEKEMVAGLF HRLMSVFRSK HNAFGCHVKS TVRCLQVLLQ
     AIDFRSLVKI NSDTLRTCAQ IFLSNMVSDL MNITKEIKNN GRYAEIKGKT LPCTSSLLFL
     YEAMLPLLTT LFCHLSKHGH GQDFLVNDIQ VGCYKIADCL YMLASPITIS RKSVKEEMEK
     HRSSIGQCLS AFACCFPVAF LEGDFNPNSR GSTVDRQHLL SESKDTSSSL LLNIPSLDNL
     LSNIEQLSNT NGKYQDAPAI FDVDIPMLCS YMSFWWQHGP TNNTQELIKF IFMCIMMLYE
     IYFRKNLSAV SSDHINRLFS ACSRLICDHI GIAHADWICH LAPFITPMIN YVTIEPVRDY
     LLPMAEKVRM QADLAFKEEE KHRMHPDVFD ESTVIELHSI LIRDVYALYP ILIKFTDLHR
     ARWLKNPCWE TNVLFEHVAF VFKLWSTSQH MKREELNFIT QFESDFMTGT SRKTGKAAVA
     FRKKKRREGK RREKDSGSIV VACLKRLLPV GLSVFGGREL DLLQKVKEKY MKKENDEKIK
     EYISSSLAVP DQEDVFDKSH WQRKLYQQIG KAQMLGIDSM SQEMVLDKII FMGVTLCNLH
     NVEHPQTFQA DAWRKIVSSQ RKRAVVACFR MVALYSIPKH RCVNLFLSAY IEKWLKSEKV
     DEDLLISEVT VASEGRMQRL REDVEEVDEQ CPPDPLSQLV QCFQRAATSE RKQLVPIVDD
     NLYIQYVRVM ASSIHINDDE QNNAEDDAIS MEAQELEKQQ LLHEQSRLAD RGVAVMVLMY
     LSACNGEPNV MVEKTLALGI HILNGGNSDV QNIMLNYLQE KKDVRFFSSI SGLMNRCSVL
     NLEIFERQLK AEGLGMGAEL SVGKHQNLND SEFICSLFRF IQLTCEGHNS EFQNYLRNQP
     GNTTSINLII CTVDYLLRLQ ESIMDFYWHF SSKEVVDEAG KAHFLKALSV CSQVFNTLTE
     SIQGPCVGNQ MALANSRLWD AINGFFFLFA HMMDKLSKNH TQLELLREFL SLQKDMIVLM
     LSMLEGNILN GSIGKQMVDT LAESQQNVQL ILKFFDMFLK LKDLTTSQAF QEFDTNKDGW
     ISPKEFLRAM EAQKMYSTEE INYLMMCTDV NNDGKIDYME FTERFHNPAK DIGFNLAILL
     TNLKEHITGD SRLDQILQTA SSMCEYFDPY LGRIEIMGSN KRVEKVYFEI KEEWLEQFNK
     PQIKQSKKDF LFNVLQDDGG EQGKLEAFVN FCEDTIFEMS HAAEISSEDR DSRIERAKKQ
     REIFTGMADK TDTISAFDII LKIMKKMGTS IVSFCRYLRP SELRQLKHSA ALHFSSMTYG
     QLILIFLKIV LFIFVTIFRG AFYLINTFFR FILLMMYGVW EEEKASSKLT AENAVHHTLP
     KDFNIVPQLY EPEKPEVYEA FGIQLTQGIG EGLSMKNPNN QPQFEKSFSM HIGNSSPFSF
     ASAESASAQN ERQLMIYSNQ IPETYTPAAV SVCNDDSNIV VKEIYEPKIA ETTSSAKGSA
     FNFLARNFYL LKYITLALAF CINAILLFYR VADNSSNDEK VVLEADNSKL QNEEHMENGI
     EEELAIHDNY YYLAHMLIFL SVAHCAASLA LLIAYYQLKV PLIIFKREKL VARKLEFEGM
     WITEMPSEDA VSGKWDSMII SSPSFPEKYW DKFVKKKVKD KYRDQFDEEE LNRLLGLDKT
     VVDGSNSSSS SGVDWCYQIW KLGVIFTDGS FQYLLMYLFF SAVGIWNPFF YAGHLIDVVI
     SFPMLQTILK SVTHNGKQLI LTVMMVLVVV YLYTVLAFNF FRKFYVQEDD GEETDSKCNN
     MISCFVFNVY AGIRAGGGIG DELQSPYGDE REAWRILFDM TFHFFIIIIL LAIMQGLIID
     AFGDLRDQQE SAQDKLESNC FICDIGKDFF ERLPHGFDHH TTKEHNLAYY LFFLMHLINK
     DDTEYTGQET YVWELYEKRC WDFFPVGECF LKQYEEQLMA S
//
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