ID A0A0V0X8Q7_9BILA Unreviewed; 945 AA.
AC A0A0V0X8Q7;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 {ECO:0000313|EMBL:KRX84333.1};
GN Name=Mblk-1 {ECO:0000313|EMBL:KRX84333.1};
GN ORFNames=T06_13509 {ECO:0000313|EMBL:KRX84333.1};
OS Trichinella sp. T6.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=92179 {ECO:0000313|EMBL:KRX84333.1, ECO:0000313|Proteomes:UP000054673};
RN [1] {ECO:0000313|EMBL:KRX84333.1, ECO:0000313|Proteomes:UP000054673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS34 {ECO:0000313|EMBL:KRX84333.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX84333.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JYDK01000007; KRX84333.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V0X8Q7; -.
DR Proteomes; UP000054673; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd08834; ArfGap_ASAP; 1.
DR CDD; cd13251; PH_ASAP; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR043593; ASAP.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR037844; PH_ASAP.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR45854:SF3; ARFGAP WITH SH3 DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45854; ASAP FAMILY MEMBER; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF07653; SH3_2; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00248; ANK; 2.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000054673};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 336..429
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 448..566
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT REPEAT 600..636
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 832..898
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 311..332
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 256..286
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 315..332
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 945 AA; 106914 MW; 110B22A7154158F6 CRC64;
MRDLKNKENF FRSFVSETED DLSSPTTSVF SNRVFRYRQA VQDFLENVAY DVEAISKLRK
GLKSFTVNQE LCMQCHENLA ESLCSLAALS NSCLATSDGN PEISTGWLRF SMMFKDLALL
NKVLVRSAKS CLIYPLAVIV KNDGRAKFDA WCYQHAGAVV ISSCCYHLSS KAVDKAFRDY
QCKAAKLEKD AKSQTTSEGF KLSQLDVAEA LLKERTILQY ELCQLFLKAS KMESKNSVGL
VESMIELYYA LHTRGIETLE ELHEFVEELE KKLDETKRSQ NEDQKLLHNL SKSLKRSVVV
LDYETAKTDE SRDSTESLSV TMLDSGPTEQ PNSSTALLKC GYLLKRSKRK MHRMWYKRRC
EIRDGFLHIW HENEAQAPIE LNLLTCQIQP SADDERCFIV QSSERKYEFQ AESENSANEW
LNLLKKAKKQ LEHEAMSSEA TSGERVEKVA MEKIKSLPGN DRCCDCTSSR DVSWLCTNLG
SLHCIDCAGV HRELGVHVSR IQSLNLDRLD RATALIPLAL GNQKVNMVLE AGYSGLKMLE
NSVERKRFIQ KKYVGRKFVV PVTDRPMEYL IETVALGSVS NLLHLYASGV DMNSIVDPDS
NSTPLLMAVA ADAGGSHLAF IQFLLQNGAD VNAQNCFGDT AVHLCIRQNK PECLKLLLLV
WNVNVELCNV DSLTPLLLAQ QLQHETCERL LNKFEQNAKS TFADIEFPLF LLNEGADDSA
ELVDVPLAMR FSTPRASQLF PTRSVLVNSD QRKSVLDYSA NGSRNSVFGE SGCLSSTFSL
PQKSFTLNRF DNSNISEPTP ANLATFSSFQ RKPQCTTVLP RPAPRKKKPT SEIRKKCRAI
YNCKADNSDE ISFSRGDLIF ITREHLSDEN DYWMEGYVAD RPDIVGRFPT SYVLRQCFLY
PVFPFLNFWK WSKLFGQQCG GVDDLRIRVP ITWQLAYFCS SMPVE
//
