GenomeNet

Database: UniProt
Entry: A0A0V0XAV9_9BILA
LinkDB: A0A0V0XAV9_9BILA
Original site: A0A0V0XAV9_9BILA 
ID   A0A0V0XAV9_9BILA        Unreviewed;      2192 AA.
AC   A0A0V0XAV9;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   22-NOV-2017, entry version 11.
DE   RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=CACNA1F {ECO:0000313|EMBL:KRX85148.1};
GN   ORFNames=T06_16828 {ECO:0000313|EMBL:KRX85148.1};
OS   Trichinella sp. T6.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichocephalida; Trichinellidae; Trichinella.
OX   NCBI_TaxID=92179 {ECO:0000313|EMBL:KRX85148.1, ECO:0000313|Proteomes:UP000054673};
RN   [1] {ECO:0000313|EMBL:KRX85148.1, ECO:0000313|Proteomes:UP000054673}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISS34 {ECO:0000313|EMBL:KRX85148.1};
RA   Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT   "Evolution of Trichinella species and genotypes.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1C
CC       gives rise to L-type calcium currents. Long-lasting (L-type)
CC       calcium channels belong to the 'high-voltage activated' (HVA)
CC       group. They are blocked by dihydropyridines (DHP),
CC       phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA
CC       (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-
CC       GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing the alpha-1C subunit play an important
CC       role in excitation-contraction coupling in the heart. Binding of
CC       calmodulin or CABP1 at the same regulatory sites results in an
CC       opposit effects on the channel function.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KRX85148.1}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; JYDK01000003; KRX85148.1; -; Genomic_DNA.
DR   Proteomes; UP000054673; Unassembled WGS sequence.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR031688; CAC1F_C.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005446; VDCC_L_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16885; CAC1F_C; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01630; LVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Complete proteome {ECO:0000313|Proteomes:UP000054673};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054673};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM    173    192       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    253    274       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    286    306       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    346    365       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    427    448       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    460    482       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    591    607       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    627    652       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    659    677       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    714    734       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    755    772       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    784    807       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    953    971       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    991   1015       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1027   1053       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1088   1107       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1198   1225       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1279   1297       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1309   1329       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1349   1366       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1378   1396       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1442   1462       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1528   1552       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1708   1742       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
SQ   SEQUENCE   2192 AA;  250656 MW;  609F692CF12A3D88 CRC64;
     MGRVFASNSK QKQEQWEYLC WHRESRPEQV VPSPIAEPHV ASIQTMVVRQ GCYIIFVVDI
     YGCYILYTDH ARSEANFNDD VNIGKELSGN EAAALLHGDE ARASRADLWQ QTLQAAVAAQ
     TESSTTTKKR QQQRKMQRNV QQERPERSLL CLGLKNPIRK LFISIVEWKP FEWLILCMIC
     ANCIALAVYQ PFPAHDSDRK NAVLVRIFFS RDRFQQNRKH KLNPQPGQRT ATVAAVGHTG
     WGVGLFSEEQ VEYIFIVVFT IECVMKVIAY GFLFHPGAYL RNGWNLLDFL IVVIGLISTA
     LSTLNIHGFD VKALRAFRVL RPLRLVSGVP SLQVVLNSIL RAMVPLFHIA LLVLFVIIIY
     AIIGLELFCG KLHKTCVDQW TGEHVPDPGP CGESHTSFHC DRSKNLVCTE NHTWPGPNDG
     ITNFDNFGLA MLTVFQCISL EGWTDVMYWV NDSVGREWPW IYFITLVILG SFFVLNLVLG
     VLSGEFSKER EKARARGLFQ KFREKQQLED DLKGYLDWIT QAEDIDLVNE EDEEQEAMDR
     EEFGADGEGG EEGGSKEEFQ RQSWFSMKIK RLKKLNRRCR RSCRRIVKSQ AFYWLVIVLV
     FLNTMVLTSE HYGQPEWLDH FQEIANLFFV VLFTLEMFLK MYSLGFVNYF VALFNRFDCF
     VVIGSILEFA LTFAGLMKPL GVSVLRSARL LRIFKVTKYW NSLRNLVASL LNSLRSIASL
     LLLLFLFIVI FALLGMQVFG GKFNTIDPNM NKPRANFDTF VQALLTVFQI LTGEDWNAVM
     YNGIAAFGGV HSIGVIVCIY FIVLFICGNY ILLNVFLAIA VDNLADAESL TAAEKEEENK
     RANEADPEDD MVVKATADED TVSVGQFHES GEVKLPFNEP TDAEDEHLAS GDDDQEREME
     NQSQFKPTAR PHRQSELNLP KKTKPIPDAS SLFLFSSTNK VRIFCNKVIN HSYFTNSVLV
     CILVSSAMLA AEDPLQASSF RNEVPKFVLN YFDYFFTTVF TIEISLKVLV YGLILHKGSF
     CRNAFNLLDM LVVGVSLTSF GLKSGAISVV KILRVLRVLR PLRAINRAKG LKHVVQCVIV
     AVKTIGNIML VTFMLEFMFA IIGVQIFKGS FFRCTDRARL TAEECKGTFI EFEGGDVTRP
     HVRNREWTNY DFNFDNVQNA MVALFVVSTF EGWPDLLHVA MDSSDEGIGP QYNARVSVAI
     FFITFIVVIA FFMMNIFVGF VIVTFQSEGE REYENCELDK NQRKCIEFAL TAKPQRRYIP
     KNRFQYKIWW FVTSQPFEYA IFIIIILNTL ILGMKHYKSS AAFDEALDVL NLFFTTVFAL
     EFICKLFALT FKHHKMTRTF DDVLDTMNLI FTGIFAMEFI LKVMAFRCKN YFGDAWNVFD
     FIIVLGSFID IIYGKVSPGS NIISINFFRL FRVMRLVKLL SRGEGIRTLL WTFMKSFQAL
     PYVALLIVLL FFIYAVIGMQ IFGKIALNSN TEIHRNNNFQ TFPSAVLVLF RSATGEAWQL
     IMLSCANTPA AMCDPESDDR GQPCGNDFAY PFFISFFMLC SFLIINLFVA VIMDNFDYLT
     RDWSILGPHH LDEFVRLWSE YDPDAKGRIK HLDVVTLLRK ISPPLGFGKL CPHRLACKRL
     VSMNMPLNSD GTVCFNSTLF ALVRTNLKIY TEERPFLFLK KSEKVESQSL VSSNIEEANE
     QLRAVIKRIW KRTPQRLLDE IVPPSGRDDE ITVGKFYATY LIQDYFRRFK KRKEVEQKET
     NMQGNITMSL QFGEEFPSDL EAFDVLIVFL HVLLLQAGLR TLHEIGPEIK RAISGNLETD
     WSKEFEEPQH RRDHSLFGTL VHALQAHYKP FIEGNLTNPA YSNVNGDLKS QEGDDEAEQQ
     HQQHQQEQQE QQQQLMFNKM NDLKSPPVKS DRDKISEFES DESVCNKPER RCNSFFSNIR
     RRMDSIVSPS IVLFDSDHDS SEHEMQERVR FVPLGSKPTG LSFEGSRWLP RKLSFRRTPI
     GGAAAVSNLQ QGNNKRLQFS NAIILDDSDP DSVLHSENVV DLTESGDDSK LSVSPPLELR
     DDAYYLDGID YNTWRPAPMG QGVRLRGRGN GRRKSRSMPL PHHEHQRNYA DVLVEKVLAD
     QGLGRYADPN LIRTTQLEIA EAYNMTEAQM HSAARSLMQR SPKYFEHMGG QRPADIKDFN
     QYSKTALLKP REINSSEEVD ISDDMNMFMS VV
//
DBGET integrated database retrieval system