ID   A0A0V0XDH0_9BILA        Unreviewed;       855 AA.
AC   A0A0V0XDH0;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   28-JUN-2023, entry version 17.
DE   RecName: Full=Angiotensin-converting enzyme {ECO:0000256|RuleBase:RU361144};
DE            EC=3.4.-.- {ECO:0000256|RuleBase:RU361144};
GN   Name=Ace {ECO:0000313|EMBL:KRX85683.1};
GN   ORFNames=T06_8104 {ECO:0000313|EMBL:KRX85683.1};
OS   Trichinella sp. T6.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichinellida; Trichinellidae; Trichinella.
OX   NCBI_TaxID=92179 {ECO:0000313|EMBL:KRX85683.1, ECO:0000313|Proteomes:UP000054673};
RN   [1] {ECO:0000313|EMBL:KRX85683.1, ECO:0000313|Proteomes:UP000054673}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISS34 {ECO:0000313|EMBL:KRX85683.1};
RA   Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT   "Evolution of Trichinella species and genotypes.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|RuleBase:RU361144};
CC       Note=Binds 1 zinc ion per subunit. {ECO:0000256|RuleBase:RU361144};
CC   -!- SIMILARITY: Belongs to the peptidase M2 family.
CC       {ECO:0000256|ARBA:ARBA00008139, ECO:0000256|RuleBase:RU361144}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KRX85683.1}.
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DR   EMBL; JYDK01000001; KRX85683.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0V0XDH0; -.
DR   Proteomes; UP000054673; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008241; F:peptidyl-dipeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd06461; M2_ACE; 1.
DR   InterPro; IPR006149; EB_dom.
DR   InterPro; IPR001548; Peptidase_M2.
DR   PANTHER; PTHR10514; ANGIOTENSIN-CONVERTING ENZYME; 1.
DR   PANTHER; PTHR10514:SF27; ANGIOTENSIN-CONVERTING ENZYME; 1.
DR   Pfam; PF01683; EB; 1.
DR   Pfam; PF01401; Peptidase_M2; 1.
DR   PRINTS; PR00791; PEPDIPTASEA.
DR   SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
PE   3: Inferred from homology;
KW   Carboxypeptidase {ECO:0000256|RuleBase:RU361144};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180,
KW   ECO:0000256|RuleBase:RU361144}; Hydrolase {ECO:0000256|RuleBase:RU361144};
KW   Metal-binding {ECO:0000256|RuleBase:RU361144};
KW   Metalloprotease {ECO:0000256|RuleBase:RU361144};
KW   Protease {ECO:0000256|RuleBase:RU361144};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054673};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Zinc {ECO:0000256|RuleBase:RU361144}.
FT   DOMAIN          747..783
FT                   /note="EB"
FT                   /evidence="ECO:0000259|Pfam:PF01683"
SQ   SEQUENCE   855 AA;  96971 MW;  32373173144D66DA CRC64;
     MRRVIEPSLQ LSRKVIIYFC KQQSAAIPSY SQIIFTNGCW LLLNIFITLS SSQRPDDTTR
     APPQAIASEN VVNELISRLL SGNGGDISSD LQQNSINIPT VNGGTVNRDD PYWNASDILE
     PNSVNDETAA LKFLVDYDKQ AEEVFSKSAE AGWCFLTNMT ANTRKELAEM DKNVVEFLHI
     SAKRAKQFNL NSIHNKKAKK QIKNLSQEGI YVLPEKKLEQ FISVQAKINQ VFADGTVCEP
     SRPPPCTMPL EPDLQRIMAT SRDVNELYYV WLAWRNAVGP PMKQSYLEMV DLFNEIAKLN
     GLKHGGEIWQ NTYGENVNLI NLLEKIYDEV RPLYDQLHAY IRNQLRKQYA SFMHQDGQIP
     AHLLGDMSGS NWINLYSDSV PYPEHHPLDV NYHLKSLNYT VEKMVRTAEK LFTSMGFGRL
     PKSFWDYSIF VRPNDRDMVC YPAAFDFKNQ KDFRIKMCAQ VTWEDFKQLI RQMTSTYYQI
     AYKEQPISFR EAANPAISYA LTNALALSVS SEDFMHSVGI LPDLENSQEK TINYLYNIAL
     REVAFIPYGV LADKWRWSLF SGDIDATNMN EKWWEYRMKY QGVKSPARRD SNDFDPGSNY
     QIAQNLPFSR QVNVIGYVIQ FQVLKGLCSA IGYQGPLHRC HFFEGKLAGE KLISAMKLGA
     SENWTDVLKI LSGSEEISGA AMMEYMEPLI QWLVKTNAET GETIGWNEYP DQFNEAEITL
     AKNISKKLPV GDIKNNAHSV SDLEGIAFPG EDCSQGQQCL ADSTCNGTVC VCPPNSVPWY
     QTCLPNDPTM VGFGPGGEGF QLDLIKEELV TEESTSSQEE SNDINGSTSS MQWKWLSIFS
     GVLFCLVHLK MYTTF
//