ID A0A0V0XFW9_TRIPS Unreviewed; 1917 AA.
AC A0A0V0XFW9;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE RecName: Full=U5 small nuclear ribonucleoprotein 200 kDa helicase {ECO:0000256|ARBA:ARBA00034541};
GN Name=Snrnp200 {ECO:0000313|EMBL:KRX86945.1};
GN ORFNames=T4E_1752 {ECO:0000313|EMBL:KRX86945.1};
OS Trichinella pseudospiralis (Parasitic roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6337 {ECO:0000313|EMBL:KRX86945.1, ECO:0000313|Proteomes:UP000054815};
RN [1] {ECO:0000313|EMBL:KRX86945.1, ECO:0000313|Proteomes:UP000054815}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS141 {ECO:0000313|EMBL:KRX86945.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX86945.1}.
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DR EMBL; JYDU01000321; KRX86945.1; -; Genomic_DNA.
DR Proteomes; UP000054815; Unassembled WGS sequence.
DR GO; GO:1990904; C:ribonucleoprotein complex; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProt.
DR CDD; cd18019; DEXHc_Brr2_1; 1.
DR CDD; cd18021; DEXHc_Brr2_2; 1.
DR CDD; cd18795; SF2_C_Ski2; 2.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR Gene3D; 1.10.3380.10; Sec63 N-terminal domain-like domain; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041094; Brr2_helicase_PWI.
DR InterPro; IPR048863; BRR2_plug.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004179; Sec63-dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR47961; DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED; 1.
DR PANTHER; PTHR47961:SF4; U5 SMALL NUCLEAR RIBONUCLEOPROTEIN HELICASE; 1.
DR Pfam; PF21188; BRR2_plug; 1.
DR Pfam; PF00270; DEAD; 2.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF18149; Helicase_PWI; 1.
DR Pfam; PF02889; Sec63; 2.
DR PIRSF; PIRSF039073; BRR2; 2.
DR SMART; SM00382; AAA; 2.
DR SMART; SM00487; DEXDc; 2.
DR SMART; SM00490; HELICc; 2.
DR SMART; SM00973; Sec63; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR SUPFAM; SSF158702; Sec63 N-terminal domain-like; 2.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 2.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:KRX86945.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000054815};
KW Ribonucleoprotein {ECO:0000313|EMBL:KRX86945.1}.
FT DOMAIN 490..673
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 683..920
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 1317..1492
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT REGION 54..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 207..238
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 54..72
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 208..234
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1917 AA; 220138 MW; 9AAA63EE63B1C803 CRC64;
MADAAARELQ YEYKANSNLV LQVDYSLIDR RPKDEATGEV LPLNADRLRG IKMGDKFYRS
KPPMPDEKKP KKSKKEKSHK ESLKLKKHGL FSDSDDFVGV YKPKTQETRQ TYDVILAFIQ
EAIGDQPRDI LCGAADEVLA TMKSDKIRDK ERKHEVELLL GPLTDERFAL LLNLGKKITD
YSLPNENKKT TGFEGDIENS YGVNVQFEES DAEDDEEVDD EIRDDSENDD EGEDTLAGST
LKASGLVEEF SIEEEQKKEL HPRDIDAYWL QRSLGKFYQD PIVAQQQSRE VLEILKMAVD
DRDCENRLVR LLGFDQFDFI RTLRQHRNMI LYCTLMASAQ SEKERQQIEA ILLETPELTK
ILHALKEADA EDFIEQERGR RRKVKTEIHS TDKNMEVDDS GWCQQRQFLD FDDLIFAQGS
HFMSNKRCQL PDGSFRKQRK GYEEVHVPAL KPRPFDSDER LIKIEELPEF AQAAFGSFKT
LNRIQSKLVK VALENDSNLL LCAPTGAGKT NVALLCILRE ISKHVNADGT INVEDFKVVY
VAPMRSLVQE MVGNFTTRLA PYKLKVGELT GDHQLTQEEI AQSQVIVCTP EKFDIITRKG
LERSFVQLVR VVIFDEIHLL HDDRGPVLEA LVARVIRNME QTQEHVRLVG LSATLPNYED
VGTFLRVEKA NVFFFDNSYR PVPLEQEYIG VTEKKAMKRF QIMNEVVYDK VLQHAGRSQI
LIFVHSRKET GKTARSLRDL CLERDTLSMF MREGSASTEI LRREADQVKN SELKDLLPYG
FAIHHAGMTR VDRTLVEDLF ADRHIQVLVS TATLAWGVNL PAHTVIIKGT QIYNPEKGRW
VELGALDIMQ MMGRAGRPQY DTKGKGIMIT NHTELQYYLS LMNQQLSVES QMISKLADCL
NAEIVLGTVN NVREAVDWLA YTYLYIRMLR APTLYGISHD EVKNDPLLEQ RRADLIHTAA
TLLDKCNMIK YERRSGIFQV TELGRIASYF YCTHETIHTY NQLLKPVMTE IELLRVFSLS
SEFKNIMVRE EEKLELLKLA ERVPIPIKEN LEEPSAKVNV LFQAYISQLK LEGFALQSDM
VYVSQSAGRL FRAIYEIVLF RSWAQLAQKT LSMCKMVERK MWQSMCPLRQ FKKLPDEIVR
KIEKKNFSFE RLHDLEPNEL GELIRIPKMG KLLHRFIHQA ISQAGTDYPY PTDNTINTAC
FWVFVEDVDC ERILHYEYFL LKQKFAEDEH TLKFFVPVFD PMPILYYIHI VSDKWLGAET
ILPVSFRHLI LPEKYPPPTE LLDLQPLPVS ALNNTDLEEL YTDEIKSFNP IQTQVFRVFY
ENKDNVFVGA PHGSGKTICA ELAILQLFKK NPNGKCVYIA PLEPLCDIVY EKWELKFGKK
MGKCVVILTG ETAVDLKLLA KGQVIISTPE KWDVLSRRWK QRKHVQNVGL YIADDLHFVG
GENGPVYEVT CSRMRFMSTQ LDTPLRIIGL SVPLSNAKDV GQWLGCSSQN TFNFHPNVRP
MPLEVHILGF NITHTASRLD AMAKQVYLSV LKHGGILRPK PMLVFVPTRK QTKVTAVDLL
AFAAADAQPK RFLLVEATEL QPFIELINDE TLKETLSCGV GYLHEGISEN DRRTVERLFD
VCAIQVLVAS RSMCYILRTH AHGVVIMDTQ YYSGRNHTYE DYPIYDILQM IGKANRSNID
EDAKCVLLCQ NSKKAFYKKF LFEPLPIESH LDHCLHDHFN AEVVTKTIEN KQEAIDYLTW
TFLYRRMTQN PNYYNLQGVS HRHLSDHLSE LVEDTLNDLE QSKCLAIIND MDVQPLNLGI
IAAYYSIHYT TIELFSMSLT SKTKIRGFLE IISNAAEFAN IPLRQKEDVV LSQLNEKIPN
KIPNAKFSDP HVKTNLLIQA HLSRIHLPAE LQSDSDEIIL KVLHRQIPQV CLLLMSL
//
